FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001135764> ?p ?o ?g. }

• W3001135764 abstract "Objective. To select an optimal (in terms of influence on the antibiotic resistance level) and cost-effective structure of antibiotic consumption in a hospital in the management of patients with acute uncomplicated pyelonephritis. Materials and Methods. Based on the literature data as well as a real practice of antibiotic administration, the cost of treatment of an acute uncomplicated pyelonephritis case with different regimens of initial antimicrobial treatment was calculated. Using mathematical modeling, changes in antimicrobial resistance of E. coli taking into consideration the current practice of the antibiotic administration were predicted. The optimal mode of antibiotic consumption in which antimicrobial resistance level would be minimal was predicted. Results. The current mode of antibiotic consumption where fluoroquinolones, 3rd generation cephalosporins, and penicillin/beta-lactamase inhibitor combinations account for more than 60% of consumption will lead to an increase in the proportion of extended-spectrum beta-lactamase (ESBL) producing E. coli by 14% over a 5-year period. At the same time, alternative (optimal) mode of antibiotic consumption (i.e. almost complete withdrawal of penicillin/beta-lactamase inhibitor combinations and fluoroquinolones from the clinical practice with the concomitant increase in consumption of carbapenems by 30% and increase in consumption of 3rd generation cephalosporins by 20%) will lead to a decrease in the proportion of ESBLproducing E. coli by 7% over 5 years. The cost of an acute uncomplicated pyelonephritis case with the current mode of antibiotic consumption will be increasing due to an increase in the proportion of ESBLproducing E. coli. At the same time, the alternative (optimal) mode of antibiotic consumption will lead to a significant reduction in the proportion of ESBL-producing E. coli. Conclusions. Use of mathematical modeling gives the opportunity to calculate changes in antimicrobial resistance of pathogens and choose the optimal mode of antibiotic consumption to reduce resistance levels." @default.
• W3001135764 created "2020-01-30" @default.
• W3001135764 creator A5011405853 @default.
• W3001135764 creator A5014746824 @default.
• W3001135764 creator A5054362085 @default.
• W3001135764 creator A5063089764 @default.
• W3001135764 creator A5065829903 @default.
• W3001135764 creator A5069520935 @default.
• W3001135764 creator A5075352554 @default.
• W3001135764 date "2018-01-01" @default.
• W3001135764 modified "2023-09-27" @default.
• W3001135764 title "Calculation of the optimal structure of antibiotic consumption in a hospital based on the predicted antimicrobial resistance in the treatment of uncomplicated acute pyelonephritis" @default.
• W3001135764 cites W1493795806 @default.
• W3001135764 cites W1560911231 @default.
• W3001135764 cites W1969141242 @default.
• W3001135764 cites W1970325755 @default.
• W3001135764 cites W1978456052 @default.
• W3001135764 cites W1983469017 @default.
• W3001135764 cites W1985653243 @default.
• W3001135764 cites W1998499222 @default.
• W3001135764 cites W2084693868 @default.
• W3001135764 cites W2088250046 @default.
• W3001135764 cites W2098969221 @default.
• W3001135764 cites W2100907980 @default.
• W3001135764 cites W2584744846 @default.
• W3001135764 doi "https://doi.org/10.36488/cmac.2018.3.223-231" @default.
• W3001135764 hasPublicationYear "2018" @default.
• W3001135764 type Work @default.
• W3001135764 sameAs 3001135764 @default.
• W3001135764 citedByCount "0" @default.
• W3001135764 crossrefType "journal-article" @default.
• W3001135764 hasAuthorship W3001135764A5011405853 @default.
• W3001135764 hasAuthorship W3001135764A5014746824 @default.
• W3001135764 hasAuthorship W3001135764A5054362085 @default.
• W3001135764 hasAuthorship W3001135764A5063089764 @default.
• W3001135764 hasAuthorship W3001135764A5065829903 @default.
• W3001135764 hasAuthorship W3001135764A5069520935 @default.
• W3001135764 hasAuthorship W3001135764A5075352554 @default.
• W3001135764 hasBestOaLocation W30011357641 @default.
• W3001135764 hasConcept C144024400 @default.
• W3001135764 hasConcept C177713679 @default.
• W3001135764 hasConcept C30772137 @default.
• W3001135764 hasConcept C36289849 @default.
• W3001135764 hasConcept C4937899 @default.
• W3001135764 hasConcept C501593827 @default.
• W3001135764 hasConcept C71924100 @default.
• W3001135764 hasConcept C86803240 @default.
• W3001135764 hasConcept C89423630 @default.
• W3001135764 hasConcept C94665300 @default.
• W3001135764 hasConceptScore W3001135764C144024400 @default.
• W3001135764 hasConceptScore W3001135764C177713679 @default.
• W3001135764 hasConceptScore W3001135764C30772137 @default.
• W3001135764 hasConceptScore W3001135764C36289849 @default.
• W3001135764 hasConceptScore W3001135764C4937899 @default.
• W3001135764 hasConceptScore W3001135764C501593827 @default.
• W3001135764 hasConceptScore W3001135764C71924100 @default.
• W3001135764 hasConceptScore W3001135764C86803240 @default.
• W3001135764 hasConceptScore W3001135764C89423630 @default.
• W3001135764 hasConceptScore W3001135764C94665300 @default.
• W3001135764 hasLocation W30011357641 @default.
• W3001135764 hasOpenAccess W3001135764 @default.
• W3001135764 hasPrimaryLocation W30011357641 @default.
• W3001135764 isParatext "false" @default.
• W3001135764 isRetracted "false" @default.
• W3001135764 magId "3001135764" @default.
• W3001135764 workType "article" @default.