Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001181702> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3001181702 abstract "Abstract The pharmaceutical salt of imatinib prepared with low purity did not meet the pharmaceutically acceptable quality. The objective of this work is to research the shape of the solubility profile of imatinib in pure and mixed solvents at T = 273.15–313.15 K. At a given temperatures (from 273.15 K to 313.15 K), the largest the solubility is in toluene (2.205 × 10−3 at 313.15 K) and the lowest is in acetonitrile (9.739 × 10−5 at 313.15 K), it decrease based on the following order in different solvents: toluene > n-propanol > acetone > ethyl acetate > acetonitrile. In system of (acetone + n-propanol), the solubility of imatinib gave an increase trend until w = 0.2 firstly, and then decreased with the increasing mass fraction of acetone. Regarding for the system of (ethyl acetate + n-propanol), it reached to the maximum (1.902 × 10−3 at 313.15 K) at w = 0.4. Two thermodynamic models including modified Apelblat equation and Jouyban-Acree model were used to correlate. The maximum values of RAD calculated by modified Apelblat equation are all less than 1.66 × 10−2, and it is no more than 2.28 × 10−2 observed in Jouyban-Acree model for mixed solvents. Meanwhile, the positive values of apparent dissolution enthalpy ( Δ H sol o ) and apparent dissolution entropy ( Δ S sol o ) indicate that the dissolution process is not only endothermic but also entropy-driving." @default.
- W3001181702 created "2020-01-30" @default.
- W3001181702 creator A5022703567 @default.
- W3001181702 creator A5062335904 @default.
- W3001181702 creator A5090123051 @default.
- W3001181702 date "2020-05-01" @default.
- W3001181702 modified "2023-09-24" @default.
- W3001181702 title "Solubility profile of imatinib in pure and mixed solvents and calculation of thermodynamic properties" @default.
- W3001181702 cites W1600161348 @default.
- W3001181702 cites W1965260090 @default.
- W3001181702 cites W1975634579 @default.
- W3001181702 cites W1981788205 @default.
- W3001181702 cites W1992781063 @default.
- W3001181702 cites W2013918877 @default.
- W3001181702 cites W2016484400 @default.
- W3001181702 cites W2021981296 @default.
- W3001181702 cites W2031077231 @default.
- W3001181702 cites W2041534729 @default.
- W3001181702 cites W2048190243 @default.
- W3001181702 cites W2060482516 @default.
- W3001181702 cites W2071448598 @default.
- W3001181702 cites W2078964293 @default.
- W3001181702 cites W2081365397 @default.
- W3001181702 cites W2085604719 @default.
- W3001181702 cites W2085944962 @default.
- W3001181702 cites W2107813887 @default.
- W3001181702 cites W2124541554 @default.
- W3001181702 cites W2546545069 @default.
- W3001181702 cites W2795874269 @default.
- W3001181702 cites W2846968738 @default.
- W3001181702 cites W2905826911 @default.
- W3001181702 cites W2918809747 @default.
- W3001181702 cites W2921381071 @default.
- W3001181702 cites W2963868947 @default.
- W3001181702 doi "https://doi.org/10.1016/j.jct.2019.106031" @default.
- W3001181702 hasPublicationYear "2020" @default.
- W3001181702 type Work @default.
- W3001181702 sameAs 3001181702 @default.
- W3001181702 citedByCount "6" @default.
- W3001181702 countsByYear W30011817022020 @default.
- W3001181702 countsByYear W30011817022021 @default.
- W3001181702 countsByYear W30011817022022 @default.
- W3001181702 crossrefType "journal-article" @default.
- W3001181702 hasAuthorship W3001181702A5022703567 @default.
- W3001181702 hasAuthorship W3001181702A5062335904 @default.
- W3001181702 hasAuthorship W3001181702A5090123051 @default.
- W3001181702 hasConcept C121332964 @default.
- W3001181702 hasConcept C147789679 @default.
- W3001181702 hasConcept C155574463 @default.
- W3001181702 hasConcept C178790620 @default.
- W3001181702 hasConcept C185592680 @default.
- W3001181702 hasConcept C2777463227 @default.
- W3001181702 hasConcept C2778142098 @default.
- W3001181702 hasConcept C2778237882 @default.
- W3001181702 hasConcept C2778270854 @default.
- W3001181702 hasConcept C2779858419 @default.
- W3001181702 hasConcept C2780471494 @default.
- W3001181702 hasConcept C2781213060 @default.
- W3001181702 hasConcept C3288061 @default.
- W3001181702 hasConcept C43617362 @default.
- W3001181702 hasConcept C88380143 @default.
- W3001181702 hasConcept C97355855 @default.
- W3001181702 hasConceptScore W3001181702C121332964 @default.
- W3001181702 hasConceptScore W3001181702C147789679 @default.
- W3001181702 hasConceptScore W3001181702C155574463 @default.
- W3001181702 hasConceptScore W3001181702C178790620 @default.
- W3001181702 hasConceptScore W3001181702C185592680 @default.
- W3001181702 hasConceptScore W3001181702C2777463227 @default.
- W3001181702 hasConceptScore W3001181702C2778142098 @default.
- W3001181702 hasConceptScore W3001181702C2778237882 @default.
- W3001181702 hasConceptScore W3001181702C2778270854 @default.
- W3001181702 hasConceptScore W3001181702C2779858419 @default.
- W3001181702 hasConceptScore W3001181702C2780471494 @default.
- W3001181702 hasConceptScore W3001181702C2781213060 @default.
- W3001181702 hasConceptScore W3001181702C3288061 @default.
- W3001181702 hasConceptScore W3001181702C43617362 @default.
- W3001181702 hasConceptScore W3001181702C88380143 @default.
- W3001181702 hasConceptScore W3001181702C97355855 @default.
- W3001181702 hasLocation W30011817021 @default.
- W3001181702 hasOpenAccess W3001181702 @default.
- W3001181702 hasPrimaryLocation W30011817021 @default.
- W3001181702 hasRelatedWork W1730467 @default.
- W3001181702 hasRelatedWork W33315243 @default.
- W3001181702 hasRelatedWork W33965263 @default.
- W3001181702 hasRelatedWork W34441780 @default.
- W3001181702 hasRelatedWork W4257329 @default.
- W3001181702 hasRelatedWork W5725845 @default.
- W3001181702 hasRelatedWork W9816518 @default.
- W3001181702 hasRelatedWork W10989103 @default.
- W3001181702 hasRelatedWork W3537173 @default.
- W3001181702 hasRelatedWork W3819413 @default.
- W3001181702 isParatext "false" @default.
- W3001181702 isRetracted "false" @default.
- W3001181702 magId "3001181702" @default.
- W3001181702 workType "article" @default.