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- W3001270003 abstract "A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with γ-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the γ-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds." @default.
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- W3001270003 date "2020-01-01" @default.
- W3001270003 modified "2023-10-09" @default.
- W3001270003 title "A one pot protocol to convert nitro-arenes into <i>N</i>-aryl amides" @default.
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- W3001270003 doi "https://doi.org/10.1039/c9ra10758d" @default.
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