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- W3001319427 abstract "We consider uncertainty in relation to clinical trials for terminal non-small cell lung cancer, which is an aggressive and difficult to treat form of cancer. Using grounded theory to analyse 85 clinical interactions between doctors, patients and family members, we argue that uncertainty is a major source of tension for terminally ill patients, with individuals confronting a choice between transitioning to palliative care or volunteering for an experimental/trial medication that might postpone death. Regardless of their efficacy, patients must also consider how such experimental treatments might impact their quality-of-life. We argue that clinical trials produce uncertainty through (i) discussions about the efficacy of clinical trials; (ii) the physiological consequences of clinical trial medications; and (iii) the impact clinical trials have on patient's prognostic understanding of their terminal cancer. Accordingly, while study participants encounter high prognostic certainty (i.e. they have a fatal cancer), they nonetheless experience considerable uncertainty in relation to their participation in clinical trials." @default.
- W3001319427 created "2020-01-30" @default.
- W3001319427 creator A5011274848 @default.
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- W3001319427 date "2020-01-24" @default.
- W3001319427 modified "2023-09-26" @default.
- W3001319427 title "Uncertainty and certain death: the role of clinical trials in terminal cancer care" @default.
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- W3001319427 doi "https://doi.org/10.1111/1467-9566.13059" @default.
- W3001319427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8345924" @default.
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