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• W3001330298 startingPage "102616" @default.
• W3001330298 abstract "BackgroundTelomeres play important roles in cancer initiation and progression. The aim of this study is to investigate whether leukocyte telomere length (LTL) is associated with aggressive prostate cancer (PCa).MethodsWe measured relative LTL in a cohort of 1,889 white PCa patients who were treated and followed up at the University of Texas MD Anderson Cancer Center and assessed its associations with aggressive disease characteristics at diagnosis and biochemical recurrence (BCR) after active treatments (radical prostatectomy and radiotherapy). We further used a Mendelian randomization (MR) approach to compute a weighted genetic risk score (GRS) predictive of LTL using 10 established LTL-associated genetic variants and determined whether this GRS is associated with aggressive PCa.FindingsLTL was significantly shorter in patients with higher Gleason scores at diagnosis. Dichotomized at the median value of LTL, patients with short LTL exhibited a 2.74-fold (95% confidence interval, 1.79–4.18, P = 3.11 × 10−6) increased risk of presenting with GS≥8 disease than those with long LTL in multivariate logistic regression analysis. Moreover, shorter LTL was significantly associated with an increased risk of BCR (hazard ratio = 1.53, 95% confidence interval, 1.01–2.34) compared to longer LTL in localized patients receiving prostatectomy or radiotherapy with a significant dose-response association (P for trend = 0.017) in multivariate Cox proportional hazards regression analysis. In MR analysis, genetically predicted short LTL was also associated with an increased risk of BCR (HR=1.73, 95% CI, 1.08–2.78).InterpretationOur results showed for the first time that LTL was shorter in PCa patients with high Gleason scores and that short LTL and genetically predicted short LTL are associated with worse prognosis in PCa patients receiving prostatectomy or radiotherapy.FundingCancer Prevention and Research Institute of Texas (CPRIT) grant (RP140556), National Cancer Institute Specialized Program of Research Excellence (SPORE) grant (CA140388), and MD Anderson Cancer Center start-up fund." @default.
• W3001330298 created "2020-01-30" @default.
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• W3001330298 date "2020-02-01" @default.
• W3001330298 modified "2023-09-26" @default.
• W3001330298 title "Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients" @default.
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• W3001330298 cites W2003409093 @default.
• W3001330298 cites W2005908883 @default.
• W3001330298 cites W2014013625 @default.
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• W3001330298 doi "https://doi.org/10.1016/j.ebiom.2019.102616" @default.
• W3001330298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6992931" @default.
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• W3001330298 hasPublicationYear "2020" @default.
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