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- W3001410725 endingPage "757" @default.
- W3001410725 startingPage "757" @default.
- W3001410725 abstract "Asthma increases worldwide without any definite reason and patient numbers double every 10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but none of them inhibited airway wall remodeling in clinical studies. Airway wall remodeling can either be induced through pro-inflammatory cytokines released by immune cells, or direct binding of IgE to smooth muscle cells, or non-immunological stimuli. Increasing evidence suggests that airway wall remodeling is initiated early in life by epigenetic events that lead to cell type specific pathologies, and modulate the interaction between epithelial and sub-epithelial cells. Animal models are only available for remodeling in allergic asthma, but none for non-allergic asthma. In human asthma, the mechanisms leading to airway wall remodeling are not well understood. In order to improve the understanding of this asthma pathology, the definition of “remodeling” needs to be better specified as it summarizes a wide range of tissue structural changes. Second, it needs to be assessed if specific remodeling patterns occur in specific asthma pheno- or endo-types. Third, the interaction of the immune cells with tissue forming cells needs to be assessed in both directions; e.g., do immune cells always stimulate tissue cells or are inflamed tissue cells calling immune cells to the rescue? This review aims to provide an overview on immunologic and non-immunologic mechanisms controlling airway wall remodeling in asthma." @default.
- W3001410725 created "2020-01-30" @default.
- W3001410725 creator A5002684303 @default.
- W3001410725 creator A5044074722 @default.
- W3001410725 creator A5077426550 @default.
- W3001410725 date "2020-01-23" @default.
- W3001410725 modified "2023-10-16" @default.
- W3001410725 title "Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma" @default.
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