FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001416050> ?p ?o ?g. }

• W3001416050 endingPage "2922" @default.
• W3001416050 startingPage "2914" @default.
• W3001416050 abstract "Identifying microRNA (miRNA) target genes remains a major challenge in understanding the roles miRNAs play in gene regulation. Furthermore, understanding which miRNA–target interactions are the most biologically important is even more difficult. We present CRISPR‐based strategies to identify essential miRNA binding sites. First, CRISPR knockout screens can easily be adapted to identify genes whose inactivation suppresses miRNA mutant phenotypes. Second, a custom approach to target individual miRNA binding sites via CRISPR can identify sites whose mutation recapitulates miRNA mutant phenotypes. We emphasize that the latter approach requires a readout of mutational profile (rather than single guide RNA abundance) when applied in a negative selection setting. Overall, the advent of CRISPR technology alongside improving empirical means of miRNA target identification will accelerate our dissection of miRNA gene regulatory networks." @default.
• W3001416050 created "2020-01-30" @default.
• W3001416050 creator A5001655208 @default.
• W3001416050 creator A5019494660 @default.
• W3001416050 date "2020-02-06" @default.
• W3001416050 modified "2023-09-25" @default.
• W3001416050 title "CRISPR screening strategies for microRNA target identification" @default.
• W3001416050 cites W1596482914 @default.
• W3001416050 cites W1722722895 @default.
• W3001416050 cites W1920303762 @default.
• W3001416050 cites W1934704664 @default.
• W3001416050 cites W1984007135 @default.
• W3001416050 cites W2003171404 @default.
• W3001416050 cites W2022231987 @default.
• W3001416050 cites W2031211461 @default.
• W3001416050 cites W2040318443 @default.
• W3001416050 cites W2045355753 @default.
• W3001416050 cites W2045685910 @default.
• W3001416050 cites W2050869737 @default.
• W3001416050 cites W2053003053 @default.
• W3001416050 cites W2059073003 @default.
• W3001416050 cites W2061174980 @default.
• W3001416050 cites W2063148079 @default.
• W3001416050 cites W2070614858 @default.
• W3001416050 cites W2078657796 @default.
• W3001416050 cites W2080800490 @default.
• W3001416050 cites W2089274312 @default.
• W3001416050 cites W2104806799 @default.
• W3001416050 cites W2114886369 @default.
• W3001416050 cites W2120456037 @default.
• W3001416050 cites W2123580197 @default.
• W3001416050 cites W2134629862 @default.
• W3001416050 cites W2148008586 @default.
• W3001416050 cites W2148440440 @default.
• W3001416050 cites W2150395782 @default.
• W3001416050 cites W2155086135 @default.
• W3001416050 cites W2156491803 @default.
• W3001416050 cites W2162674813 @default.
• W3001416050 cites W2165675181 @default.
• W3001416050 cites W2165869860 @default.
• W3001416050 cites W2252568502 @default.
• W3001416050 cites W2416625694 @default.
• W3001416050 cites W2470801200 @default.
• W3001416050 cites W2525686694 @default.
• W3001416050 cites W2528044351 @default.
• W3001416050 cites W2592245372 @default.
• W3001416050 cites W2611446801 @default.
• W3001416050 cites W2612797603 @default.
• W3001416050 cites W2745064085 @default.
• W3001416050 cites W2772524563 @default.
• W3001416050 cites W2885580646 @default.
• W3001416050 cites W2889513238 @default.
• W3001416050 cites W2893438687 @default.
• W3001416050 cites W2947777875 @default.
• W3001416050 cites W2948399858 @default.
• W3001416050 cites W4245053291 @default.
• W3001416050 doi "https://doi.org/10.1111/febs.15218" @default.
• W3001416050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31975506" @default.
• W3001416050 hasPublicationYear "2020" @default.
• W3001416050 type Work @default.
• W3001416050 sameAs 3001416050 @default.
• W3001416050 citedByCount "13" @default.
• W3001416050 countsByYear W30014160502020 @default.
• W3001416050 countsByYear W30014160502021 @default.
• W3001416050 countsByYear W30014160502022 @default.
• W3001416050 countsByYear W30014160502023 @default.
• W3001416050 crossrefType "journal-article" @default.
• W3001416050 hasAuthorship W3001416050A5001655208 @default.
• W3001416050 hasAuthorship W3001416050A5019494660 @default.
• W3001416050 hasBestOaLocation W30014160501 @default.
• W3001416050 hasConcept C104317684 @default.
• W3001416050 hasConcept C116834253 @default.
• W3001416050 hasConcept C127716648 @default.
• W3001416050 hasConcept C143065580 @default.
• W3001416050 hasConcept C145059251 @default.
• W3001416050 hasConcept C54355233 @default.
• W3001416050 hasConcept C59822182 @default.
• W3001416050 hasConcept C67705224 @default.
• W3001416050 hasConcept C70721500 @default.
• W3001416050 hasConcept C86803240 @default.
• W3001416050 hasConcept C98108389 @default.
• W3001416050 hasConceptScore W3001416050C104317684 @default.
• W3001416050 hasConceptScore W3001416050C116834253 @default.
• W3001416050 hasConceptScore W3001416050C127716648 @default.
• W3001416050 hasConceptScore W3001416050C143065580 @default.
• W3001416050 hasConceptScore W3001416050C145059251 @default.
• W3001416050 hasConceptScore W3001416050C54355233 @default.
• W3001416050 hasConceptScore W3001416050C59822182 @default.
• W3001416050 hasConceptScore W3001416050C67705224 @default.
• W3001416050 hasConceptScore W3001416050C70721500 @default.
• W3001416050 hasConceptScore W3001416050C86803240 @default.
• W3001416050 hasConceptScore W3001416050C98108389 @default.
• W3001416050 hasFunder F4320337357 @default.
• W3001416050 hasIssue "14" @default.
• W3001416050 hasLocation W30014160501 @default.
• W3001416050 hasOpenAccess W3001416050 @default.
• W3001416050 hasPrimaryLocation W30014160501 @default.
• W3001416050 hasRelatedWork W1530845363 @default.

• next