FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001465488> ?p ?o ?g. }

• W3001465488 abstract "Summary Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential processes including neuronal activity. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under protein crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus unclear how kinesin-1 acts as an efficient transporter in crowded intracellular environments. Here, we demonstrate that TRAK1 (Milton), an adaptor protein essential for mitochondrial trafficking, activates kinesin-1 and increases its robustness of stepping in protein crowding conditions. Interaction with TRAK1 i) facilitated kinesin-1 navigation around obstacles, ii) increased the probability of kinesin-1 passing through cohesive envelopes of tau and iii) increased the run length of kinesin-1 in cell lysate. We explain the enhanced motility by the observed direct interaction of TRAK1 with microtubules, providing an additional anchor for the kinesin-1-TRAK1 complex. We propose adaptor-mediated tethering as a mechanism regulating kinesin-1 motility in various cellular environments." @default.
• W3001465488 created "2020-01-30" @default.
• W3001465488 creator A5002043565 @default.
• W3001465488 creator A5004885735 @default.
• W3001465488 creator A5006008163 @default.
• W3001465488 creator A5010579301 @default.
• W3001465488 creator A5029420984 @default.
• W3001465488 creator A5060128303 @default.
• W3001465488 creator A5063442560 @default.
• W3001465488 creator A5066069524 @default.
• W3001465488 creator A5079215454 @default.
• W3001465488 date "2020-01-22" @default.
• W3001465488 modified "2023-10-10" @default.
• W3001465488 title "Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments" @default.
• W3001465488 cites W1757334295 @default.
• W3001465488 cites W1885810519 @default.
• W3001465488 cites W1926421284 @default.
• W3001465488 cites W1970302092 @default.
• W3001465488 cites W1970866062 @default.
• W3001465488 cites W1971756681 @default.
• W3001465488 cites W1971805318 @default.
• W3001465488 cites W1974345291 @default.
• W3001465488 cites W1975321314 @default.
• W3001465488 cites W1982743797 @default.
• W3001465488 cites W1989729787 @default.
• W3001465488 cites W1991744562 @default.
• W3001465488 cites W1993762028 @default.
• W3001465488 cites W1996715055 @default.
• W3001465488 cites W1996764498 @default.
• W3001465488 cites W1997563565 @default.
• W3001465488 cites W2001410029 @default.
• W3001465488 cites W2015171213 @default.
• W3001465488 cites W2015229379 @default.
• W3001465488 cites W2019606851 @default.
• W3001465488 cites W2022214576 @default.
• W3001465488 cites W2027266940 @default.
• W3001465488 cites W2030637794 @default.
• W3001465488 cites W2031792634 @default.
• W3001465488 cites W2046237540 @default.
• W3001465488 cites W2046720103 @default.
• W3001465488 cites W2047911803 @default.
• W3001465488 cites W2049611094 @default.
• W3001465488 cites W2057096287 @default.
• W3001465488 cites W2057733928 @default.
• W3001465488 cites W2057959735 @default.
• W3001465488 cites W2061237420 @default.
• W3001465488 cites W2061500740 @default.
• W3001465488 cites W2062135485 @default.
• W3001465488 cites W2065978277 @default.
• W3001465488 cites W2066575706 @default.
• W3001465488 cites W2080648518 @default.
• W3001465488 cites W2082631326 @default.
• W3001465488 cites W2085796374 @default.
• W3001465488 cites W2095631043 @default.
• W3001465488 cites W2095841601 @default.
• W3001465488 cites W2096435582 @default.
• W3001465488 cites W2098718365 @default.
• W3001465488 cites W2107421715 @default.
• W3001465488 cites W2111537613 @default.
• W3001465488 cites W2130271828 @default.
• W3001465488 cites W2131227198 @default.
• W3001465488 cites W2135621635 @default.
• W3001465488 cites W2136354065 @default.
• W3001465488 cites W2136870704 @default.
• W3001465488 cites W2142639362 @default.
• W3001465488 cites W2146367213 @default.
• W3001465488 cites W2148905482 @default.
• W3001465488 cites W2149090615 @default.
• W3001465488 cites W2153578959 @default.
• W3001465488 cites W2158671383 @default.
• W3001465488 cites W2160708064 @default.
• W3001465488 cites W2167279371 @default.
• W3001465488 cites W2168166944 @default.
• W3001465488 cites W2168750058 @default.
• W3001465488 cites W2478998833 @default.
• W3001465488 cites W2519360406 @default.
• W3001465488 cites W2583253518 @default.
• W3001465488 cites W2606756014 @default.
• W3001465488 cites W2740670974 @default.
• W3001465488 cites W2747063405 @default.
• W3001465488 cites W2771222777 @default.
• W3001465488 cites W2781631021 @default.
• W3001465488 cites W2896387873 @default.
• W3001465488 cites W2901125126 @default.
• W3001465488 cites W2946253886 @default.
• W3001465488 cites W2953010568 @default.
• W3001465488 cites W2971448217 @default.
• W3001465488 cites W2971541306 @default.
• W3001465488 cites W2972853102 @default.
• W3001465488 cites W4254171273 @default.
• W3001465488 doi "https://doi.org/10.1101/2020.01.22.915066" @default.
• W3001465488 hasPublicationYear "2020" @default.
• W3001465488 type Work @default.
• W3001465488 sameAs 3001465488 @default.
• W3001465488 citedByCount "3" @default.
• W3001465488 countsByYear W30014654882020 @default.
• W3001465488 countsByYear W30014654882022 @default.
• W3001465488 crossrefType "posted-content" @default.
• W3001465488 hasAuthorship W3001465488A5002043565 @default.
• W3001465488 hasAuthorship W3001465488A5004885735 @default.

• next