FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001467920> ?p ?o ?g. }

• W3001467920 endingPage "2731" @default.
• W3001467920 startingPage "2717" @default.
• W3001467920 abstract "Gas chromatography–mass spectrometry (GC-MS) platforms are typically run in electron ionization (EI) mode for mass spectral matching and metabolite annotation. With the advent of high resolution mass spectrometry (HRMS), soft ionization techniques such as chemical ionization (CI) may provide additional coverage for compound identification. We evaluated NIST SRM 1950 pooled plasma reference sample using a HRGC-MS instrument [GC-Orbitrap-MS with electron ionization (EI), positive chemical ionization (PCI), and negative CI (NCI) capabilities] for metabolite annotation and quantification to assess the suitability of the platform for routine discovery metabolomics. Using both open source and vendor workflows, we validated the spectral matches with an in-house spectral library (Wake Forest CPM GC-MS spectral and retention time libraries) of EI-MS and CI-MS/MS spectra obtained from chemical standards. We confidently [metabolomics standards initiative (MSI) confidence level 2] identified 263, 93, and 65 metabolites using EI, PCI, and NCI modes, respectively, of which 270 metabolites (64%) were validated using our Wake Forest CPM GC-MS spectral libraries. When compared to published LC-MS-based efforts using the same NIST SRM 1950 plasma sample, there was only 17% overlap between the two platforms. In addition, the metabolomics analysis of community approved standard human plasma demonstrated the ability of EI- and CI-MS modes of analysis using a HRGC-MS platform to enable reproducible and interoperable spectral matching." @default.
• W3001467920 created "2020-01-30" @default.
• W3001467920 creator A5011582725 @default.
• W3001467920 creator A5059469183 @default.
• W3001467920 date "2020-01-24" @default.
• W3001467920 modified "2023-09-26" @default.
• W3001467920 title "High Resolution GC-Orbitrap-MS Metabolomics Using Both Electron Ionization and Chemical Ionization for Analysis of Human Plasma" @default.
• W3001467920 cites W1502855202 @default.
• W3001467920 cites W1543068333 @default.
• W3001467920 cites W1597941165 @default.
• W3001467920 cites W1611854178 @default.
• W3001467920 cites W1914090123 @default.
• W3001467920 cites W1934481644 @default.
• W3001467920 cites W1976327004 @default.
• W3001467920 cites W1976892175 @default.
• W3001467920 cites W1980669969 @default.
• W3001467920 cites W1982167561 @default.
• W3001467920 cites W1984053258 @default.
• W3001467920 cites W1988203407 @default.
• W3001467920 cites W1996264786 @default.
• W3001467920 cites W2002862204 @default.
• W3001467920 cites W2005341433 @default.
• W3001467920 cites W2006317824 @default.
• W3001467920 cites W2007308599 @default.
• W3001467920 cites W2019402080 @default.
• W3001467920 cites W2020230458 @default.
• W3001467920 cites W2042043007 @default.
• W3001467920 cites W2044001108 @default.
• W3001467920 cites W2052766619 @default.
• W3001467920 cites W2057662606 @default.
• W3001467920 cites W2058236355 @default.
• W3001467920 cites W2059327215 @default.
• W3001467920 cites W2075447512 @default.
• W3001467920 cites W2092696869 @default.
• W3001467920 cites W2101551644 @default.
• W3001467920 cites W2105700464 @default.
• W3001467920 cites W2118925636 @default.
• W3001467920 cites W2144054945 @default.
• W3001467920 cites W2144450838 @default.
• W3001467920 cites W2151346683 @default.
• W3001467920 cites W2162539049 @default.
• W3001467920 cites W2321396110 @default.
• W3001467920 cites W2322516649 @default.
• W3001467920 cites W2334686117 @default.
• W3001467920 cites W2341031032 @default.
• W3001467920 cites W2473139211 @default.
• W3001467920 cites W2513837146 @default.
• W3001467920 cites W2548222833 @default.
• W3001467920 cites W2586644082 @default.
• W3001467920 cites W2587034866 @default.
• W3001467920 cites W2609624643 @default.
• W3001467920 cites W2613257777 @default.
• W3001467920 cites W2755433859 @default.
• W3001467920 cites W2762311793 @default.
• W3001467920 cites W2764166773 @default.
• W3001467920 cites W2769063482 @default.
• W3001467920 cites W2769738191 @default.
• W3001467920 cites W2786155603 @default.
• W3001467920 cites W2790580419 @default.
• W3001467920 cites W2800177705 @default.
• W3001467920 cites W2802909948 @default.
• W3001467920 cites W2803961630 @default.
• W3001467920 cites W2806945897 @default.
• W3001467920 cites W2807894653 @default.
• W3001467920 cites W2807983544 @default.
• W3001467920 cites W2809791459 @default.
• W3001467920 cites W2886006743 @default.
• W3001467920 cites W2888303476 @default.
• W3001467920 cites W2889116472 @default.
• W3001467920 cites W2906914952 @default.
• W3001467920 cites W2922522932 @default.
• W3001467920 cites W2989913725 @default.
• W3001467920 cites W2990663352 @default.
• W3001467920 cites W4211085285 @default.
• W3001467920 cites W4230720465 @default.
• W3001467920 cites W4294326454 @default.
• W3001467920 cites W980612985 @default.
• W3001467920 doi "https://doi.org/10.1021/acs.jproteome.9b00774" @default.
• W3001467920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31978300" @default.
• W3001467920 hasPublicationYear "2020" @default.
• W3001467920 type Work @default.
• W3001467920 sameAs 3001467920 @default.
• W3001467920 citedByCount "25" @default.
• W3001467920 countsByYear W30014679202020 @default.
• W3001467920 countsByYear W30014679202021 @default.
• W3001467920 countsByYear W30014679202022 @default.
• W3001467920 countsByYear W30014679202023 @default.
• W3001467920 crossrefType "journal-article" @default.
• W3001467920 hasAuthorship W3001467920A5011582725 @default.
• W3001467920 hasAuthorship W3001467920A5059469183 @default.
• W3001467920 hasBestOaLocation W30014679202 @default.
• W3001467920 hasConcept C113196181 @default.
• W3001467920 hasConcept C138850012 @default.
• W3001467920 hasConcept C145148216 @default.
• W3001467920 hasConcept C162356407 @default.
• W3001467920 hasConcept C178790620 @default.
• W3001467920 hasConcept C185592680 @default.
• W3001467920 hasConcept C198291218 @default.

• next