FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001501825> ?p ?o ?g. }

• W3001501825 endingPage "1644.e1" @default.
• W3001501825 startingPage "1634" @default.
• W3001501825 abstract "Because of historical safety concerns with the use of long-acting β-agonists (LABA) in asthma, step-down from inhaled corticosteroid (ICS)/LABA combination therapy to ICS monotherapy is recommended once asthma control is achieved.To evaluate the benefit/risk question about whether patients with asthma who achieve disease control on fixed-dose ICS/LABA combination therapy, such as mometasone furoate/formoterol fumarate (MF/F), should continue with this therapy or be stepped down to ICS monotherapy, such as MF.Using data from 8447 clinically stable patients with persistent asthma in the Safety Pharma Investigation of Respiratory Outcomes trial who had been receiving a stable dose of ICS/LABA for ≥4 weeks, this post hoc analysis evaluated the risk of serious asthma outcomes (SAOs) (adjudicated hospitalization, intubation, or death) and asthma exacerbation (AEX) (composite of hospitalizations ≥24 hours, emergency visits <24 hours requiring systemic corticosteroid, or systemic corticosteroid for ≥3 consecutive days) in participants randomized to remain on ICS/LABA (MF/F) or step down to ICS (MF) for 26 weeks.There was no significant difference in SAO risk among patients maintained on ICS/LABA with MF/F compared with those who stepped down from ICS/LABA to MF (hazard ratio [HR], 1.03 [95% confidence interval (CI): 0.61, 1.75], P = .913). The risk of AEX was significantly lower in patients maintained on ICS/LABA with MF/F compared with those who stepped down from ICS/LABA to MF (HR, 0.87 [95% CI: 0.78, 0.98], P = .020).In this post hoc analysis of a large clinical trial dataset, maintenance on ICS/LABA with MF/F is not associated with an increased risk of SAOs and also significantly reduces the risk of AEX compared with step-down from ICS/LABA to MF." @default.
• W3001501825 created "2020-01-30" @default.
• W3001501825 creator A5009972416 @default.
• W3001501825 creator A5013834421 @default.
• W3001501825 creator A5020858694 @default.
• W3001501825 creator A5030244193 @default.
• W3001501825 creator A5046082259 @default.
• W3001501825 creator A5054228072 @default.
• W3001501825 creator A5069610412 @default.
• W3001501825 creator A5071294861 @default.
• W3001501825 creator A5083879499 @default.
• W3001501825 creator A5089141968 @default.
• W3001501825 creator A5090715649 @default.
• W3001501825 date "2020-05-01" @default.
• W3001501825 modified "2023-09-24" @default.
• W3001501825 title "Serious Asthma Outcomes and Asthma Exacerbations with Maintenance on Inhaled Corticosteroid (Mometasone Furoate)/Long-Acting Beta Agonist (Formoterol) Combination Compared to Step Down to Mometasone Monotherapy" @default.
• W3001501825 cites W1969312325 @default.
• W3001501825 cites W2016715361 @default.
• W3001501825 cites W2030048781 @default.
• W3001501825 cites W2050460305 @default.
• W3001501825 cites W2056770521 @default.
• W3001501825 cites W2064174736 @default.
• W3001501825 cites W2069105771 @default.
• W3001501825 cites W2091144167 @default.
• W3001501825 cites W2091971768 @default.
• W3001501825 cites W2092334938 @default.
• W3001501825 cites W2111609315 @default.
• W3001501825 cites W2117649440 @default.
• W3001501825 cites W2134436842 @default.
• W3001501825 cites W2134510352 @default.
• W3001501825 cites W2164297158 @default.
• W3001501825 cites W2293620483 @default.
• W3001501825 cites W2299879287 @default.
• W3001501825 cites W2320802854 @default.
• W3001501825 cites W2514696388 @default.
• W3001501825 cites W2517095451 @default.
• W3001501825 cites W2517626453 @default.
• W3001501825 cites W2528354469 @default.
• W3001501825 cites W2905037802 @default.
• W3001501825 doi "https://doi.org/10.1016/j.jaip.2020.01.021" @default.
• W3001501825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31981733" @default.
• W3001501825 hasPublicationYear "2020" @default.
• W3001501825 type Work @default.
• W3001501825 sameAs 3001501825 @default.
• W3001501825 citedByCount "1" @default.
• W3001501825 countsByYear W30015018252021 @default.
• W3001501825 crossrefType "journal-article" @default.
• W3001501825 hasAuthorship W3001501825A5009972416 @default.
• W3001501825 hasAuthorship W3001501825A5013834421 @default.
• W3001501825 hasAuthorship W3001501825A5020858694 @default.
• W3001501825 hasAuthorship W3001501825A5030244193 @default.
• W3001501825 hasAuthorship W3001501825A5046082259 @default.
• W3001501825 hasAuthorship W3001501825A5054228072 @default.
• W3001501825 hasAuthorship W3001501825A5069610412 @default.
• W3001501825 hasAuthorship W3001501825A5071294861 @default.
• W3001501825 hasAuthorship W3001501825A5083879499 @default.
• W3001501825 hasAuthorship W3001501825A5089141968 @default.
• W3001501825 hasAuthorship W3001501825A5090715649 @default.
• W3001501825 hasConcept C118552586 @default.
• W3001501825 hasConcept C126322002 @default.
• W3001501825 hasConcept C207103383 @default.
• W3001501825 hasConcept C2776042228 @default.
• W3001501825 hasConcept C2776136866 @default.
• W3001501825 hasConcept C2776804153 @default.
• W3001501825 hasConcept C2776999253 @default.
• W3001501825 hasConcept C2777014857 @default.
• W3001501825 hasConcept C2779871671 @default.
• W3001501825 hasConcept C2780724011 @default.
• W3001501825 hasConcept C2781348165 @default.
• W3001501825 hasConcept C42219234 @default.
• W3001501825 hasConcept C44249647 @default.
• W3001501825 hasConcept C67761136 @default.
• W3001501825 hasConcept C71924100 @default.
• W3001501825 hasConceptScore W3001501825C118552586 @default.
• W3001501825 hasConceptScore W3001501825C126322002 @default.
• W3001501825 hasConceptScore W3001501825C207103383 @default.
• W3001501825 hasConceptScore W3001501825C2776042228 @default.
• W3001501825 hasConceptScore W3001501825C2776136866 @default.
• W3001501825 hasConceptScore W3001501825C2776804153 @default.
• W3001501825 hasConceptScore W3001501825C2776999253 @default.
• W3001501825 hasConceptScore W3001501825C2777014857 @default.
• W3001501825 hasConceptScore W3001501825C2779871671 @default.
• W3001501825 hasConceptScore W3001501825C2780724011 @default.
• W3001501825 hasConceptScore W3001501825C2781348165 @default.
• W3001501825 hasConceptScore W3001501825C42219234 @default.
• W3001501825 hasConceptScore W3001501825C44249647 @default.
• W3001501825 hasConceptScore W3001501825C67761136 @default.
• W3001501825 hasConceptScore W3001501825C71924100 @default.
• W3001501825 hasFunder F4320307770 @default.
• W3001501825 hasFunder F4320307773 @default.
• W3001501825 hasFunder F4320307776 @default.
• W3001501825 hasFunder F4320307778 @default.
• W3001501825 hasFunder F4320307781 @default.
• W3001501825 hasFunder F4320308970 @default.
• W3001501825 hasFunder F4320322546 @default.
• W3001501825 hasFunder F4320332193 @default.
• W3001501825 hasFunder F4320332932 @default.
• W3001501825 hasFunder F4320333801 @default.

• next