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• W3001511086 abstract "The time profile of total proteins and albumin in line with two amino acids, Phe and Glu, are of great importance due to their indicative value of the healing and/or deterioration of burn wounds. In this experiment, rats exposed to scalding that produced a second-degree burn were divided into four groups: control, placebo, MEBO ointment, and copper (I) nicotinate complex ointment (an antioxidant anti-inflammatory) for four weeks. The three treatments showed noticeable similarities in the Phe profiles, with a slight drop 24 hours post burn, a peak elevation by the second week, and a slight, insignificant decline by the third week, with the placebo group showing highest values over normal (P< 0.05). In the Glu profile, large differences were observed: two set profiles, one representing MEBO and copper (I) nicotinate showed one peak in the second week, and the other representing placebo showed two peaks in the first and third weeks. Albumin and total protein time profiles showed the same trend throughout the whole experiment, and are in line with a reformed metabolic state parallel to wound closure. These results reveal that MEBO and copper nicotinate have comparable effects on wound healing in scald burns, and that plasma Glu profile is a better systemic indicator reflecting the regularity and steadiness of the healing process in MEBO and copper complex treatment.Les évolutions temporelles de la protidémie, de l’albuminémie ainsi que de Phe et Glu sont de bons prédicteurs de l’évolution vers la cicatrisation ou non des brûlures. Dans cette étude expérimentale, des rats ayant subi une brûlure du 2ème degré par ébouillantement ont été divisés en 4 groupes : contrôle, placebo (P), pansements au MEBO ou au complexe cuivre (I) – acide nicotinique (CuNic) pendant 4 semaines. Les trois groupes traités avaient des profils de Phe superposables, avec une légère diminution initiale, un pic dans la 2ème semaine et une augmentation non significative durant la 3ème quand le groupe P avait des valeurs élevées (p<0,05). Les profils de Glu étaient plus disparates : un (MEBO et CuNic) avec un pic en 2ème semaine, les autres avec 2 pics (1ère et 3ème semaines). Ces profils étaient aussi observés avec les protides et l’albumine et correspondaient à des évolutions cicatricielles et métaboliques. MEBO et CuNic ont des effets comparables sur la cicatrisation après ébouillantement, au mieux explorés par l’évolution de Glu." @default.
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• W3001511086 date "2018-12-31" @default.
• W3001511086 modified "2023-09-27" @default.
• W3001511086 title "Comparative plasma phenylalanine and glutamate profiles in scalded rats treated with Mebo or Copper (I) Nicotinate Complex." @default.
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