Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001585015> ?p ?o ?g. }
- W3001585015 endingPage "424" @default.
- W3001585015 startingPage "417" @default.
- W3001585015 abstract "mRNA function is controlled by RNA-binding proteins. The specificity of RNA-binding factors for their targets is critical in that it enables all subsequent regulation. Despite widespread recognition of the pervasive role RNA-binding proteins play in development and disease, they remain challenging to target with small molecules. A renaissance in RNA therapeutics has led to the identification of modifications that substantially increase RNA stability. When combined with information regarding specificity, a new class of oligonucleotide mimics has emerged as a means to competitively disrupt the regulation of endogenous substrates. These decoys have been used to inhibit RNA-binding proteins in living animals. Decoys will likely provide new insights into the expansive roles of RNA-binding proteins in biology and disease. Here, we describe examples where they have been used and discuss how they could be applied to new targets." @default.
- W3001585015 created "2020-01-30" @default.
- W3001585015 creator A5048496766 @default.
- W3001585015 creator A5051317898 @default.
- W3001585015 creator A5086593985 @default.
- W3001585015 date "2020-01-28" @default.
- W3001585015 modified "2023-10-05" @default.
- W3001585015 title "Molecular entrapment by RNA: an emerging tool for disrupting protein–RNA interactions<i>in vivo</i>" @default.
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