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- W3001694842 abstract "Abstract Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 locus and reinforces repression of selected target genes in a cellular context-dependent fashion. EfnA5 mediates Bmi1-dependent proliferation and invasion in vitro and tumour formation in an allograft model. Importantly, we show that this novel Polycomb feed-forward loop is also active in human GIC and we provide pre-clinical evidence of druggability of the EFNA5 signalling pathway in GBM xenografts overexpressing Bmi1." @default.
- W3001694842 created "2020-01-30" @default.
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- W3001694842 date "2020-01-27" @default.
- W3001694842 modified "2023-10-17" @default.
- W3001694842 title "Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma" @default.
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- W3001694842 doi "https://doi.org/10.1038/s41388-020-1161-3" @default.
- W3001694842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7082224" @default.
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