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• W3001787777 startingPage "3680" @default.
• W3001787777 abstract "Most organisms adapt to the 24-h cycle of the Earth's rotation by anticipating the time of the day through light-dark cycles. The internal time-keeping system of the circadian clocks has been developed to ensure this anticipation. The circadian system governs the rhythmicity of nearly all physiological and behavioral processes in mammals. In this review, we summarize current knowledge stemming from rodent and human studies on the tight interconnection between the circadian system and metabolism in the body. In particular, we highlight recent advances emphasizing the roles of the peripheral clocks located in the metabolic organs in regulating glucose, lipid, and protein homeostasis at the organismal and cellular levels. Experimental disruption of circadian system in rodents is associated with various metabolic disturbance phenotypes. Similarly, perturbation of the clockwork in humans is linked to the development of metabolic diseases. We discuss recent studies that reveal roles of the circadian system in the temporal coordination of metabolism under physiological conditions and in the development of human pathologies." @default.
• W3001787777 created "2020-01-30" @default.
• W3001787777 creator A5004983468 @default.
• W3001787777 creator A5010380813 @default.
• W3001787777 creator A5040291166 @default.
• W3001787777 date "2020-05-01" @default.
• W3001787777 modified "2023-10-12" @default.
• W3001787777 title "Circadian Clocks Make Metabolism Run" @default.
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