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- W3001909815 endingPage "1097.e6" @default.
- W3001909815 startingPage "1088" @default.
- W3001909815 abstract "Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, possibly due to changes in blood cells and molecules involved in hemostasis. They have increased platelet counts and reactivity as well as increased platelet-derived large extracellular vesicles. Coagulation is continuously activated in patients with IBD, based on measured markers of thrombin generation, and the anticoagulant functions of endothelial cells are damaged. Furthermore, fibrinogen is increased and fibrin clots are denser. However, pathogenesis of thrombosis in patients with IBD appears to differ from that of patients without IBD. Patients with IBD also take drugs that might contribute to risk of thrombosis, complicating the picture. We review the features of homeostasis that are altered in patients with IBD and possible mechanisms of this relationship. Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, possibly due to changes in blood cells and molecules involved in hemostasis. They have increased platelet counts and reactivity as well as increased platelet-derived large extracellular vesicles. Coagulation is continuously activated in patients with IBD, based on measured markers of thrombin generation, and the anticoagulant functions of endothelial cells are damaged. Furthermore, fibrinogen is increased and fibrin clots are denser. However, pathogenesis of thrombosis in patients with IBD appears to differ from that of patients without IBD. Patients with IBD also take drugs that might contribute to risk of thrombosis, complicating the picture. We review the features of homeostasis that are altered in patients with IBD and possible mechanisms of this relationship." @default.
- W3001909815 created "2020-01-30" @default.
- W3001909815 creator A5002166266 @default.
- W3001909815 creator A5042884495 @default.
- W3001909815 creator A5077698321 @default.
- W3001909815 creator A5087655089 @default.
- W3001909815 creator A5089541378 @default.
- W3001909815 date "2021-06-01" @default.
- W3001909815 modified "2023-10-18" @default.
- W3001909815 title "Shedding Light on Hemostasis in Patients With Inflammatory Bowel Diseases" @default.
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