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• W3002000986 abstract "Abstract Purpose To evaluate HPV and p16 ink4a status as prognostic factors in patients with invasive vulvar cancer. Methods Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16 ink4a status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16 ink4a positivity. Results 135 patients were included in the analysis. 32 (23.7%) showed a p16 ink4a expression of over 25%. Disease-free and disease-specific survival was longer in p16 ink4a positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16 ink4a positivity was an independent parameter for DFS ( p = 0.025, HR: 2.120 (1.100–4.085)), but not for DSS ( p = 0.926, HR: 1.029 (0.558–1.901), in contrast to age and tumor stage. Conclusions Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16 ink4a positive invasive vulvar cancer." @default.
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• W3002000986 date "2020-01-22" @default.
• W3002000986 modified "2023-10-09" @default.
• W3002000986 title "The impact of p16ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study" @default.
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• W3002000986 doi "https://doi.org/10.1007/s00404-020-05431-7" @default.
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