FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002012016> ?p ?o ?g. }

• W3002012016 endingPage "e0008015" @default.
• W3002012016 startingPage "e0008015" @default.
• W3002012016 abstract "Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae. Opisthorchiasis can lead to severe hepatobiliary morbidity and is classified as a carcinogenic agent. Here we investigate the time-resolved metabolic response to Opisthorchis felineus infection in an animal model.Thirty golden hamsters were divided in three groups: severe infection (50 metacercariae/hamster), mild infection (15 metacercariae/hamster) and uninfected (vehicle-PBS) groups. Each group consisted of equal number of male and female animals. Plasma samples were collected one day before the infection and then every two weeks up to week 22 after infection. The samples were subjected to 1H Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate statistical modelling.The time-resolved study of the metabolic response to Opisthorchis infection in plasma in the main lines agrees with our previous report on urine data. The response reaches its peak around the 4th week of infection and stabilizes after the 10th week. Yet, unlike the urinary data there is no strong effect of the gender in the data and the intensity of infection is presented in the first two principal components of the PCA model. The main trends of the metabolic response to the infection in blood plasma are the transient depletion of essential amino acids and an increase in lipoprotein and cholesterol concentrations.The time resolved metabolic signature of Opisthorchis infection in the hamster's plasma shows a coherent shift in amino acids and lipid metabolism. Our work provides insight into the metabolic basis of the host response on the helminth infection." @default.
• W3002012016 created "2020-01-30" @default.
• W3002012016 creator A5001612833 @default.
• W3002012016 creator A5063900976 @default.
• W3002012016 creator A5064047079 @default.
• W3002012016 creator A5068143584 @default.
• W3002012016 creator A5069235857 @default.
• W3002012016 creator A5076327499 @default.
• W3002012016 creator A5081162203 @default.
• W3002012016 date "2020-01-24" @default.
• W3002012016 modified "2023-09-30" @default.
• W3002012016 title "Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus)" @default.
• W3002012016 cites W1880451551 @default.
• W3002012016 cites W1971012017 @default.
• W3002012016 cites W1979344712 @default.
• W3002012016 cites W1981162008 @default.
• W3002012016 cites W2011635427 @default.
• W3002012016 cites W2017453862 @default.
• W3002012016 cites W2023632463 @default.
• W3002012016 cites W2026013333 @default.
• W3002012016 cites W2042701219 @default.
• W3002012016 cites W2046262868 @default.
• W3002012016 cites W2048967679 @default.
• W3002012016 cites W2058011330 @default.
• W3002012016 cites W2063519822 @default.
• W3002012016 cites W2064186732 @default.
• W3002012016 cites W2071424589 @default.
• W3002012016 cites W2074953921 @default.
• W3002012016 cites W2081293740 @default.
• W3002012016 cites W2083637865 @default.
• W3002012016 cites W2086395365 @default.
• W3002012016 cites W2098562143 @default.
• W3002012016 cites W2151672959 @default.
• W3002012016 cites W2159321123 @default.
• W3002012016 cites W2159798213 @default.
• W3002012016 cites W2162021059 @default.
• W3002012016 cites W2166172387 @default.
• W3002012016 cites W2166971958 @default.
• W3002012016 cites W2169423026 @default.
• W3002012016 cites W2414180903 @default.
• W3002012016 cites W2442625585 @default.
• W3002012016 cites W2605675262 @default.
• W3002012016 cites W2605908465 @default.
• W3002012016 cites W2619174872 @default.
• W3002012016 cites W2735068388 @default.
• W3002012016 cites W2767174281 @default.
• W3002012016 cites W2768375473 @default.
• W3002012016 cites W2782133429 @default.
• W3002012016 cites W2805639236 @default.
• W3002012016 cites W2883708472 @default.
• W3002012016 cites W2887824885 @default.
• W3002012016 cites W2890426109 @default.
• W3002012016 cites W2916248758 @default.
• W3002012016 cites W4297855338 @default.
• W3002012016 doi "https://doi.org/10.1371/journal.pntd.0008015" @default.
• W3002012016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7002010" @default.
• W3002012016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31978047" @default.
• W3002012016 hasPublicationYear "2020" @default.
• W3002012016 type Work @default.
• W3002012016 sameAs 3002012016 @default.
• W3002012016 citedByCount "8" @default.
• W3002012016 countsByYear W30020120162020 @default.
• W3002012016 countsByYear W30020120162021 @default.
• W3002012016 countsByYear W30020120162022 @default.
• W3002012016 countsByYear W30020120162023 @default.
• W3002012016 crossrefType "journal-article" @default.
• W3002012016 hasAuthorship W3002012016A5001612833 @default.
• W3002012016 hasAuthorship W3002012016A5063900976 @default.
• W3002012016 hasAuthorship W3002012016A5064047079 @default.
• W3002012016 hasAuthorship W3002012016A5068143584 @default.
• W3002012016 hasAuthorship W3002012016A5069235857 @default.
• W3002012016 hasAuthorship W3002012016A5076327499 @default.
• W3002012016 hasAuthorship W3002012016A5081162203 @default.
• W3002012016 hasBestOaLocation W30020120161 @default.
• W3002012016 hasConcept C126322002 @default.
• W3002012016 hasConcept C134018914 @default.
• W3002012016 hasConcept C13590703 @default.
• W3002012016 hasConcept C165901193 @default.
• W3002012016 hasConcept C203014093 @default.
• W3002012016 hasConcept C2778362869 @default.
• W3002012016 hasConcept C2778575167 @default.
• W3002012016 hasConcept C2779525107 @default.
• W3002012016 hasConcept C2780431383 @default.
• W3002012016 hasConcept C2780838300 @default.
• W3002012016 hasConcept C42407357 @default.
• W3002012016 hasConcept C71924100 @default.
• W3002012016 hasConcept C86803240 @default.
• W3002012016 hasConceptScore W3002012016C126322002 @default.
• W3002012016 hasConceptScore W3002012016C134018914 @default.
• W3002012016 hasConceptScore W3002012016C13590703 @default.
• W3002012016 hasConceptScore W3002012016C165901193 @default.
• W3002012016 hasConceptScore W3002012016C203014093 @default.
• W3002012016 hasConceptScore W3002012016C2778362869 @default.
• W3002012016 hasConceptScore W3002012016C2778575167 @default.
• W3002012016 hasConceptScore W3002012016C2779525107 @default.
• W3002012016 hasConceptScore W3002012016C2780431383 @default.
• W3002012016 hasConceptScore W3002012016C2780838300 @default.
• W3002012016 hasConceptScore W3002012016C42407357 @default.

• next