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• W3002016602 abstract "Abstract In immune-mediated hepatitis, type 2 innate lymphoid cells (ILC2) as well as effector CD4 + T cells have been shown to drive disease pathology. However, less is known about mechanisms involved in the regulation of ILC2 function during liver inflammation. We showed that in homeostasis, hepatic ILC2 constituted a very small population with a naive, inactive phenotype. During immune-mediated hepatitis, the cytokines IL-33 and IFNγ were expressed in liver tissue. IL-33 induced strong activation and expression of type 2 cytokines as well as IL-6 by hepatic ILC2 while IFNγ suppressed cytokine production. Interestingly, this inhibitory effect was overcome by IL-33. The phenotype of activated hepatic ILC2 were stable since they did not show functional plasticity in response to liver inflammation-induced cytokines. Moreover, hepatic ILC2 induced a Th2 phenotype in activated CD4 + T cells, which increased ILC2-derived cytokine expression via IL-2. In contrast, Th1 cells inhibited survival of ILC2 by production of IFNγ. Thus, hepatic ILC2 function is regulated by IL-33, IL-2, and IFNγ. While IL-33 and IL-2 support hepatic ILC2 activation, their inflammatory activity in immune-mediated hepatitis might be limited by infiltrating IFNγ-expressing Th1 cells." @default.
• W3002016602 created "2020-01-30" @default.
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• W3002016602 date "2020-01-23" @default.
• W3002016602 modified "2023-09-29" @default.
• W3002016602 title "Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells" @default.
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• W3002016602 doi "https://doi.org/10.1038/s41598-020-57985-w" @default.
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