Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002048103> ?p ?o ?g. }
- W3002048103 abstract "Abstract Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with macrophage tracer ( R )-[ 11 C]PK11195 were encouraging, but the imaging signal could be further improved by reduction of background uptake. Recently, the novel macrophage tracer [ 18 F]fluoro-PEG-folate was developed. This tracer showed excellent targeting of the folate receptor β on activated macrophages in synovial tissue in a preclinical arthritic rat model. We performed three substudies to investigate the biodistribution, potential for imaging arthritis and kinetic properties of [18F]fluoro-PEG-folate in RA patients. Firstly, biodistribution demonstrated fast clearance of [ 18 F]fluoro-PEG-folate from heart and blood vessels and no dose limiting uptake in organs. Secondly, [ 18 F]fluoro-PEG-folate showed uptake in arthritic joints with significantly lower background and hence significantly higher target-to-background ratios as compared to reference macrophage tracer ( R )-[ 11 C]PK11195. Lastly, dynamic scanning demonstrated fast tracer uptake in affected joints, reaching a plateau after 1 minute, co-existing with a rapid blood clearance. In conclusion, this first in man study demonstrates the potential of [ 18 F]fluoro-PEG-folate to image arthritis activity in RA with favourable imaging characteristics of rapid clearance and low background uptake, that allow for detection of inflammatory activity in the whole body." @default.
- W3002048103 created "2020-01-30" @default.
- W3002048103 creator A5003272069 @default.
- W3002048103 creator A5003445744 @default.
- W3002048103 creator A5007946879 @default.
- W3002048103 creator A5012446734 @default.
- W3002048103 creator A5023581145 @default.
- W3002048103 creator A5027096828 @default.
- W3002048103 creator A5042628953 @default.
- W3002048103 creator A5051352493 @default.
- W3002048103 creator A5065258380 @default.
- W3002048103 creator A5076012975 @default.
- W3002048103 creator A5077588358 @default.
- W3002048103 creator A5087967286 @default.
- W3002048103 creator A5090169437 @default.
- W3002048103 date "2020-01-23" @default.
- W3002048103 modified "2023-10-01" @default.
- W3002048103 title "First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis" @default.
- W3002048103 cites W1481992265 @default.
- W3002048103 cites W1543288352 @default.
- W3002048103 cites W1607142236 @default.
- W3002048103 cites W1839954256 @default.
- W3002048103 cites W1966425460 @default.
- W3002048103 cites W1968652079 @default.
- W3002048103 cites W1969508240 @default.
- W3002048103 cites W1993388378 @default.
- W3002048103 cites W2001917088 @default.
- W3002048103 cites W2005564022 @default.
- W3002048103 cites W2009193838 @default.
- W3002048103 cites W2015766239 @default.
- W3002048103 cites W2034460421 @default.
- W3002048103 cites W2040515772 @default.
- W3002048103 cites W2054759893 @default.
- W3002048103 cites W2056306723 @default.
- W3002048103 cites W2060459188 @default.
- W3002048103 cites W2067848116 @default.
- W3002048103 cites W2078046981 @default.
- W3002048103 cites W2079082252 @default.
- W3002048103 cites W2083628264 @default.
- W3002048103 cites W2108595830 @default.
- W3002048103 cites W2120393706 @default.
- W3002048103 cites W2128952811 @default.
- W3002048103 cites W2134390918 @default.
- W3002048103 cites W2148317617 @default.
- W3002048103 cites W2158772803 @default.
- W3002048103 cites W2165241753 @default.
- W3002048103 cites W2165820735 @default.
- W3002048103 cites W2167446675 @default.
- W3002048103 cites W2170631530 @default.
- W3002048103 cites W2172032147 @default.
- W3002048103 cites W2255314558 @default.
- W3002048103 cites W2328761257 @default.
- W3002048103 cites W2332873237 @default.
- W3002048103 cites W2335568744 @default.
- W3002048103 cites W2473952238 @default.
- W3002048103 cites W2588524480 @default.
- W3002048103 cites W2602061033 @default.
- W3002048103 cites W2617601840 @default.
- W3002048103 cites W2735347267 @default.
- W3002048103 cites W2781545991 @default.
- W3002048103 cites W2791389567 @default.
- W3002048103 cites W2803973327 @default.
- W3002048103 cites W2895757261 @default.
- W3002048103 cites W2952442195 @default.
- W3002048103 cites W2976680862 @default.
- W3002048103 cites W4211111012 @default.
- W3002048103 cites W4361808359 @default.
- W3002048103 doi "https://doi.org/10.1038/s41598-020-57841-x" @default.
- W3002048103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6978456" @default.
- W3002048103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31974480" @default.
- W3002048103 hasPublicationYear "2020" @default.
- W3002048103 type Work @default.
- W3002048103 sameAs 3002048103 @default.
- W3002048103 citedByCount "38" @default.
- W3002048103 countsByYear W30020481032020 @default.
- W3002048103 countsByYear W30020481032021 @default.
- W3002048103 countsByYear W30020481032022 @default.
- W3002048103 countsByYear W30020481032023 @default.
- W3002048103 crossrefType "journal-article" @default.
- W3002048103 hasAuthorship W3002048103A5003272069 @default.
- W3002048103 hasAuthorship W3002048103A5003445744 @default.
- W3002048103 hasAuthorship W3002048103A5007946879 @default.
- W3002048103 hasAuthorship W3002048103A5012446734 @default.
- W3002048103 hasAuthorship W3002048103A5023581145 @default.
- W3002048103 hasAuthorship W3002048103A5027096828 @default.
- W3002048103 hasAuthorship W3002048103A5042628953 @default.
- W3002048103 hasAuthorship W3002048103A5051352493 @default.
- W3002048103 hasAuthorship W3002048103A5065258380 @default.
- W3002048103 hasAuthorship W3002048103A5076012975 @default.
- W3002048103 hasAuthorship W3002048103A5077588358 @default.
- W3002048103 hasAuthorship W3002048103A5087967286 @default.
- W3002048103 hasAuthorship W3002048103A5090169437 @default.
- W3002048103 hasBestOaLocation W30020481031 @default.
- W3002048103 hasConcept C10138342 @default.
- W3002048103 hasConcept C121608353 @default.
- W3002048103 hasConcept C126322002 @default.
- W3002048103 hasConcept C150903083 @default.
- W3002048103 hasConcept C162324750 @default.
- W3002048103 hasConcept C185592680 @default.
- W3002048103 hasConcept C202751555 @default.