Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002068784> ?p ?o ?g. }
- W3002068784 endingPage "340" @default.
- W3002068784 startingPage "340" @default.
- W3002068784 abstract "Diabetic retinopathy (DR) is a significant cause of blindness in working-age adults worldwide. Lack of effective strategies to prevent or reduce vision loss is a major problem. Since the degeneration of retinal neurons is an early event in the diabetic retina, studies to characterize the molecular mechanisms of diabetes-induced retinal neuronal damage and dysfunction are of high significance. We have demonstrated that spermine oxidase (SMOX), a mediator of polyamine oxidation is critically involved in causing neurovascular damage in the retina. The involvement of SMOX in diabetes-induced retinal neuronal damage is completely unknown. Utilizing the streptozotocin-induced mouse model of diabetes, the impact of the SMOX inhibitor, MDL 72527, on neuronal damage and dysfunction in the diabetic retina was investigated. Retinal function was assessed by electroretinography (ERG) and retinal architecture was evaluated using spectral domain-optical coherence tomography. Retinal cryosections were prepared for immunolabeling of inner retinal neurons and retinal lysates were used for Western blotting. We observed a marked decrease in retinal function in diabetic mice compared to the non-diabetic controls. Treatment with MDL 72527 significantly improved the ERG responses in diabetic retinas. Diabetes-induced retinal thinning was also inhibited by the MDL 72527 treatment. Our analysis further showed that diabetes-induced retinal ganglion cell damage and neurodegeneration were markedly attenuated by MDL 72527 treatment. These results strongly implicate SMOX in diabetes-induced retinal neurodegeneration and visual dysfunction." @default.
- W3002068784 created "2020-01-30" @default.
- W3002068784 creator A5014954875 @default.
- W3002068784 creator A5032953381 @default.
- W3002068784 creator A5035368802 @default.
- W3002068784 creator A5044459542 @default.
- W3002068784 creator A5048447444 @default.
- W3002068784 creator A5052840597 @default.
- W3002068784 creator A5053810929 @default.
- W3002068784 creator A5058254450 @default.
- W3002068784 creator A5085025467 @default.
- W3002068784 date "2020-01-25" @default.
- W3002068784 modified "2023-10-16" @default.
- W3002068784 title "Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice" @default.
- W3002068784 cites W110576239 @default.
- W3002068784 cites W1495063308 @default.
- W3002068784 cites W1576556919 @default.
- W3002068784 cites W1965199078 @default.
- W3002068784 cites W1967709839 @default.
- W3002068784 cites W1969830087 @default.
- W3002068784 cites W1971945408 @default.
- W3002068784 cites W1981121080 @default.
- W3002068784 cites W1981349401 @default.
- W3002068784 cites W1981931963 @default.
- W3002068784 cites W1989927734 @default.
- W3002068784 cites W1993968665 @default.
- W3002068784 cites W1995363602 @default.
- W3002068784 cites W2005391194 @default.
- W3002068784 cites W2007017828 @default.
- W3002068784 cites W2010204260 @default.
- W3002068784 cites W2013248933 @default.
- W3002068784 cites W2016823378 @default.
- W3002068784 cites W2019732054 @default.
- W3002068784 cites W2024750606 @default.
- W3002068784 cites W2025036216 @default.
- W3002068784 cites W2025791120 @default.
- W3002068784 cites W2031740343 @default.
- W3002068784 cites W2032531051 @default.
- W3002068784 cites W2033020058 @default.
- W3002068784 cites W2033546154 @default.
- W3002068784 cites W2034112847 @default.
- W3002068784 cites W2034722240 @default.
- W3002068784 cites W2035334171 @default.
- W3002068784 cites W2038496635 @default.
- W3002068784 cites W2039632062 @default.
- W3002068784 cites W2042667133 @default.
- W3002068784 cites W2056089533 @default.
- W3002068784 cites W2059921071 @default.
- W3002068784 cites W2063572584 @default.
- W3002068784 cites W2063663031 @default.
- W3002068784 cites W2064818200 @default.
- W3002068784 cites W2067652095 @default.
- W3002068784 cites W2074205020 @default.
- W3002068784 cites W2074925042 @default.
- W3002068784 cites W2075510198 @default.
- W3002068784 cites W2086256951 @default.
- W3002068784 cites W2087205893 @default.
- W3002068784 cites W2090484837 @default.
- W3002068784 cites W2095908024 @default.
- W3002068784 cites W2098492027 @default.
- W3002068784 cites W2103329755 @default.
- W3002068784 cites W2120487349 @default.
- W3002068784 cites W2120850024 @default.
- W3002068784 cites W2138480916 @default.
- W3002068784 cites W2139869364 @default.
- W3002068784 cites W2145242334 @default.
- W3002068784 cites W2147457499 @default.
- W3002068784 cites W2151487984 @default.
- W3002068784 cites W2161921948 @default.
- W3002068784 cites W2164511025 @default.
- W3002068784 cites W2169355774 @default.
- W3002068784 cites W2253045889 @default.
- W3002068784 cites W2320748172 @default.
- W3002068784 cites W2329651024 @default.
- W3002068784 cites W2394648753 @default.
- W3002068784 cites W2404312699 @default.
- W3002068784 cites W2410835618 @default.
- W3002068784 cites W2466609853 @default.
- W3002068784 cites W2511422297 @default.
- W3002068784 cites W2511553800 @default.
- W3002068784 cites W2520939061 @default.
- W3002068784 cites W2555217151 @default.
- W3002068784 cites W2557362735 @default.
- W3002068784 cites W2566906855 @default.
- W3002068784 cites W2609340129 @default.
- W3002068784 cites W2616764639 @default.
- W3002068784 cites W2737068901 @default.
- W3002068784 cites W2740350297 @default.
- W3002068784 cites W2753138435 @default.
- W3002068784 cites W2787482787 @default.
- W3002068784 cites W2793401320 @default.
- W3002068784 cites W2794677028 @default.
- W3002068784 cites W2809489644 @default.
- W3002068784 cites W2886353102 @default.
- W3002068784 cites W2895969593 @default.
- W3002068784 cites W2900889362 @default.
- W3002068784 cites W2908733748 @default.
- W3002068784 cites W2917521450 @default.