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- W3002128510 endingPage "602" @default.
- W3002128510 startingPage "585" @default.
- W3002128510 abstract "The role of Wnt/β-catenin pathway is well established in vertebrates in development, tissue homeostasis, and carcinogenesis. β-catenin knockout yields an embryoniclethal phenotype in mice due to a defect in gastrulation. This chapter highlights the role of the Wnt/β-cateninsignaling pathway and of β-catenin independent of the canonical Wnt pathway in liver physiology and pathobiology. A crucial function of β-catenin is to act as a bridge between the cytoplasmic domain of the cadherins and the actin-containing-cytoskeleton as component of the adherens junctions. Wnt signaling promotes the posterior endodermal fate and suppresses the anterior endodermal fate during gastrulation andearly somitogenesis. The Wnt/β-catenin pathway has been comprehensively studied in liver regeneration that ensues after partial hepatectomy. Hepatocytes are responsible for the conversion of cholesterol into bile acids. Chronic injury to the liver results in hepatic fibrosis, a wound healing response, which can lead to cirrhosis if the insult continues." @default.
- W3002128510 created "2020-01-30" @default.
- W3002128510 creator A5045031054 @default.
- W3002128510 date "2020-01-24" @default.
- W3002128510 modified "2023-10-17" @default.
- W3002128510 title "β‐Catenin Signaling" @default.
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