FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002164665> ?p ?o ?g. }

• W3002164665 endingPage "42" @default.
• W3002164665 startingPage "36" @default.
• W3002164665 abstract "Gastric epithelial cells (GES-1) stimulated by Helicobacter pylori (H. pylori) would affect the expression of related genes and induce the immune response of the cells. Abnormal methylation of DNA was one of the main causes. The aim of this study was to investigate phosphoinositol-3-kinase adaptor protein 1(PIK3AP1), which was screened from the chip data as an immune gene candidate to against the inflammatory response of cells caused by H. pylori infection. PIK3AP1 plays a key role in PI3K/AKT signaling pathway. The gene chip analysis and experimental results confirmed that PIK3AP1 expression was downregulated and PIK3AP1 promoter was hypermethylated after H. pylori stimulation in GES-1 cells. Meanwhile, the expression level of PIK3AP1 was significantly upregulated after 5-aza-dc treatment, and its expression was higher after 5-aza-dc and H. pylori co-treatment than that of H. pylori treatment but lower than that of 5-aza-dc treatment. Therefore, hypermethylation was the main reason for the down-regulation of PIK3AP1 after H. pylori stimulation. In addition, the intervention of PIK3AP1 inhibited the expression of downstream gene AKT, and suppressing the expression of the immunoinflammatory gene IL-6 in GES-1 cells. Furthermore, the intervention of PIK3AP1 would promote cell proliferation. In summary, hypermethylation of the PIK3AP1 promoter was accompanied by reduction of the expression level of PIK3AP1 in GES-1 cells by H. pylori stimulation. The expression of PIK3AP1, AKT, and IL-6 genes was positively correlated, Meanwhile, the PIK3AP1 can affect the proliferation of GES-1 cells. These results would be helpful to understand the innate immune response function of PIK3AP1 to pathogenic bacterial infection in the stomach." @default.
• W3002164665 created "2020-01-30" @default.
• W3002164665 creator A5008659449 @default.
• W3002164665 creator A5019008945 @default.
• W3002164665 creator A5025977895 @default.
• W3002164665 creator A5029587959 @default.
• W3002164665 creator A5040529823 @default.
• W3002164665 creator A5043166126 @default.
• W3002164665 creator A5046804024 @default.
• W3002164665 creator A5052912712 @default.
• W3002164665 creator A5061698045 @default.
• W3002164665 creator A5073064156 @default.
• W3002164665 creator A5083434243 @default.
• W3002164665 date "2020-03-01" @default.
• W3002164665 modified "2023-10-18" @default.
• W3002164665 title "Abnormal methylation of PIK3AP1 was involved in regulating the immune inflammatory response of GES-1 cells induced by Helicobacter pylori" @default.
• W3002164665 cites W1529055939 @default.
• W3002164665 cites W1592799844 @default.
• W3002164665 cites W1953946757 @default.
• W3002164665 cites W1979328506 @default.
• W3002164665 cites W1981440811 @default.
• W3002164665 cites W1992958712 @default.
• W3002164665 cites W1995854274 @default.
• W3002164665 cites W1999587546 @default.
• W3002164665 cites W2002581229 @default.
• W3002164665 cites W2016292931 @default.
• W3002164665 cites W2048236539 @default.
• W3002164665 cites W2070588389 @default.
• W3002164665 cites W2108905338 @default.
• W3002164665 cites W2109923711 @default.
• W3002164665 cites W2133843864 @default.
• W3002164665 cites W2136546686 @default.
• W3002164665 cites W2142357559 @default.
• W3002164665 cites W2157231599 @default.
• W3002164665 cites W2158038587 @default.
• W3002164665 cites W2185435041 @default.
• W3002164665 cites W2556511519 @default.
• W3002164665 cites W2577166044 @default.
• W3002164665 cites W2773048443 @default.
• W3002164665 cites W27857866 @default.
• W3002164665 cites W2944376344 @default.
• W3002164665 doi "https://doi.org/10.1016/j.bbrc.2020.01.007" @default.
• W3002164665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31980170" @default.
• W3002164665 hasPublicationYear "2020" @default.
• W3002164665 type Work @default.
• W3002164665 sameAs 3002164665 @default.
• W3002164665 citedByCount "6" @default.
• W3002164665 countsByYear W30021646652020 @default.
• W3002164665 countsByYear W30021646652021 @default.
• W3002164665 countsByYear W30021646652023 @default.
• W3002164665 crossrefType "journal-article" @default.
• W3002164665 hasAuthorship W3002164665A5008659449 @default.
• W3002164665 hasAuthorship W3002164665A5019008945 @default.
• W3002164665 hasAuthorship W3002164665A5025977895 @default.
• W3002164665 hasAuthorship W3002164665A5029587959 @default.
• W3002164665 hasAuthorship W3002164665A5040529823 @default.
• W3002164665 hasAuthorship W3002164665A5043166126 @default.
• W3002164665 hasAuthorship W3002164665A5046804024 @default.
• W3002164665 hasAuthorship W3002164665A5052912712 @default.
• W3002164665 hasAuthorship W3002164665A5061698045 @default.
• W3002164665 hasAuthorship W3002164665A5073064156 @default.
• W3002164665 hasAuthorship W3002164665A5083434243 @default.
• W3002164665 hasConcept C104317684 @default.
• W3002164665 hasConcept C127561419 @default.
• W3002164665 hasConcept C150194340 @default.
• W3002164665 hasConcept C153911025 @default.
• W3002164665 hasConcept C190727270 @default.
• W3002164665 hasConcept C203014093 @default.
• W3002164665 hasConcept C2776409635 @default.
• W3002164665 hasConcept C33288867 @default.
• W3002164665 hasConcept C502942594 @default.
• W3002164665 hasConcept C54355233 @default.
• W3002164665 hasConcept C62478195 @default.
• W3002164665 hasConcept C75217442 @default.
• W3002164665 hasConcept C86554907 @default.
• W3002164665 hasConcept C86803240 @default.
• W3002164665 hasConcept C8891405 @default.
• W3002164665 hasConcept C95444343 @default.
• W3002164665 hasConceptScore W3002164665C104317684 @default.
• W3002164665 hasConceptScore W3002164665C127561419 @default.
• W3002164665 hasConceptScore W3002164665C150194340 @default.
• W3002164665 hasConceptScore W3002164665C153911025 @default.
• W3002164665 hasConceptScore W3002164665C190727270 @default.
• W3002164665 hasConceptScore W3002164665C203014093 @default.
• W3002164665 hasConceptScore W3002164665C2776409635 @default.
• W3002164665 hasConceptScore W3002164665C33288867 @default.
• W3002164665 hasConceptScore W3002164665C502942594 @default.
• W3002164665 hasConceptScore W3002164665C54355233 @default.
• W3002164665 hasConceptScore W3002164665C62478195 @default.
• W3002164665 hasConceptScore W3002164665C75217442 @default.
• W3002164665 hasConceptScore W3002164665C86554907 @default.
• W3002164665 hasConceptScore W3002164665C86803240 @default.
• W3002164665 hasConceptScore W3002164665C8891405 @default.
• W3002164665 hasConceptScore W3002164665C95444343 @default.
• W3002164665 hasFunder F4320321001 @default.
• W3002164665 hasIssue "1" @default.
• W3002164665 hasLocation W30021646651 @default.
• W3002164665 hasLocation W30021646652 @default.

• next