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- W3002172210 abstract "Parkin is a protein involved in familial Parkinson’s disease (PD), a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons. More than 20 years have passed since the discovery of Parkin; since that time, another familial PD protein has been identified: PINK1, which acts upstream of Parkin. PINK1 is a protein kinase that monitors mitochondrial integrity by sensing disability status, whereas Parkin is a ubiquitin–protein ligase that attaches ubiquitin chains to malfunctioning mitochondria as a degradation signal. Both enzymes cooperatively facilitate autophagic clearance of damaged mitochondria (also known as mitophagy). Collectively, the PINK1-Parkin axis functions as the core machinery for mitophagy in neurons, and deficiency in this pathway causes early-onset PD. In this review, I will discuss how the PINK1-Parkin study has progressed, with the personal episodes I have experienced." @default.
- W3002172210 created "2020-01-30" @default.
- W3002172210 creator A5025748633 @default.
- W3002172210 date "2020-10-01" @default.
- W3002172210 modified "2023-09-27" @default.
- W3002172210 title "The PINK1–Parkin axis: An Overview" @default.
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- W3002172210 doi "https://doi.org/10.1016/j.neures.2020.01.006" @default.
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