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• W3002426628 abstract "Abstract Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins into host cells. A subset of these injected protein ‘effectors’ are enzymes that inhibit the function of host proteins by catalyzing the addition of unusual post-translational modifications. The E. coli and Citrobacter rodentium NleB effectors, as well as the Salmonella enterica SseK effectors are glycosyltransferases that modify host protein substrates with N-acetyl glucosamine (GlcNAc) on arginine residues. This post-translational modification disrupts the normal functioning of host immune response proteins. T3SS effectors are thought to be inactive within the bacterium and fold into their active conformations after they are injected, due to the activity of chaperones that keep the effectors in a structural state permissive for secretion. While performing mass spectrometry experiments to identify glycosylation substrates of NleB orthologs, we unexpectedly observed that the bacterial glutathione synthetase (GshB) is glycosylated by NleB on arginine residue R256. NleB-mediated glycosylation of GshB resulted in enhanced GshB activity, leading to an increase in glutathione production, and promoted C. rodentium survival in oxidative stress conditions. These data represent, to our knowledge, the first intra-bacterial activity for a T3SS effector and show that arginine-GlcNAcylation, once thought to be restricted to host cell compartments, also plays an important role in regulating bacterial physiology." @default.
• W3002426628 created "2020-01-30" @default.
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• W3002426628 date "2020-01-23" @default.
• W3002426628 modified "2023-09-26" @default.
• W3002426628 title "An intra-bacterial activity for a T3SS effector" @default.
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• W3002426628 doi "https://doi.org/10.1038/s41598-020-58062-y" @default.
• W3002426628 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6978387" @default.
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• W3002426628 hasPublicationYear "2020" @default.
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