FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002452051> ?p ?o ?g. }

• W3002452051 abstract "Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach. However, the outcomes from clinical trials evaluating VNS in HF have been mixed, and the mechanisms underlying this treatment remain poorly understood. Intermittent high-frequency VNS (pulse width 300 µs, 30 Hz stimulation, 30 s on, and 300 s off) was used in healthy sheep and sheep in which established HF had been induced by 4 weeks rapid ventricular pacing to assess (a) the effects of VNS on intrinsic cardiac vagal tone, (b) whether VNS delays the progression of established HF, and (c) whether high-frequency VNS affects the regulation of cardiomyocyte calcium handling in health and disease. VNS had no effect on resting heart rate or intrinsic vagal tone in the healthy heart. Although fewer VNS-treated animals showed subjective signs of heart failure at 6 weeks, overall VNS did not slow the progression of clinical or echocardiographic signs of HF. Chronic VNS did not affect left ventricular cardiomyocyte calcium handling in healthy sheep. Rapid ventricular pacing decreased the L-type calcium current and calcium transient amplitude, but chronic VNS did not rescue dysfunctional calcium handling. Overall, high-frequency VNS did not prevent progression of established HF or influence cellular excitation–contraction coupling. However, a different model of HF or selection of different stimulation parameters may have yielded different results. These results highlight the need for greater insight into VNS dosing and parameter selection and a deeper understanding of its physiological effects." @default.
• W3002452051 created "2020-01-30" @default.
• W3002452051 creator A5013529600 @default.
• W3002452051 creator A5017254873 @default.
• W3002452051 creator A5025399070 @default.
• W3002452051 creator A5033032369 @default.
• W3002452051 creator A5042642401 @default.
• W3002452051 creator A5055459566 @default.
• W3002452051 creator A5057200391 @default.
• W3002452051 creator A5073540592 @default.
• W3002452051 date "2020-01-01" @default.
• W3002452051 modified "2023-10-15" @default.
• W3002452051 title "Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling" @default.
• W3002452051 cites W1528862705 @default.
• W3002452051 cites W1574790479 @default.
• W3002452051 cites W1964816788 @default.
• W3002452051 cites W1968399101 @default.
• W3002452051 cites W1976824259 @default.
• W3002452051 cites W1985431801 @default.
• W3002452051 cites W2003517127 @default.
• W3002452051 cites W2004135099 @default.
• W3002452051 cites W2026520142 @default.
• W3002452051 cites W2028960923 @default.
• W3002452051 cites W2045350116 @default.
• W3002452051 cites W2054909389 @default.
• W3002452051 cites W2055186112 @default.
• W3002452051 cites W2068613600 @default.
• W3002452051 cites W2068884498 @default.
• W3002452051 cites W2069014482 @default.
• W3002452051 cites W2083792839 @default.
• W3002452051 cites W2091005514 @default.
• W3002452051 cites W2103596313 @default.
• W3002452051 cites W2109454934 @default.
• W3002452051 cites W2116095873 @default.
• W3002452051 cites W2120723181 @default.
• W3002452051 cites W2133851654 @default.
• W3002452051 cites W2170643083 @default.
• W3002452051 cites W2175257784 @default.
• W3002452051 cites W2281780984 @default.
• W3002452051 cites W2337818477 @default.
• W3002452051 cites W2338638760 @default.
• W3002452051 cites W2427094903 @default.
• W3002452051 cites W2583520792 @default.
• W3002452051 cites W2741766149 @default.
• W3002452051 cites W2752489571 @default.
• W3002452051 cites W2893721043 @default.
• W3002452051 cites W2901371411 @default.
• W3002452051 cites W2942786244 @default.
• W3002452051 cites W4296816736 @default.
• W3002452051 doi "https://doi.org/10.14814/phy2.14321" @default.
• W3002452051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6971309" @default.
• W3002452051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31961064" @default.
• W3002452051 hasPublicationYear "2020" @default.
• W3002452051 type Work @default.
• W3002452051 sameAs 3002452051 @default.
• W3002452051 citedByCount "4" @default.
• W3002452051 countsByYear W30024520512020 @default.
• W3002452051 countsByYear W30024520512021 @default.
• W3002452051 countsByYear W30024520512022 @default.
• W3002452051 countsByYear W30024520512023 @default.
• W3002452051 crossrefType "journal-article" @default.
• W3002452051 hasAuthorship W3002452051A5013529600 @default.
• W3002452051 hasAuthorship W3002452051A5017254873 @default.
• W3002452051 hasAuthorship W3002452051A5025399070 @default.
• W3002452051 hasAuthorship W3002452051A5033032369 @default.
• W3002452051 hasAuthorship W3002452051A5042642401 @default.
• W3002452051 hasAuthorship W3002452051A5055459566 @default.
• W3002452051 hasAuthorship W3002452051A5057200391 @default.
• W3002452051 hasAuthorship W3002452051A5073540592 @default.
• W3002452051 hasBestOaLocation W30024520511 @default.
• W3002452051 hasConcept C126322002 @default.
• W3002452051 hasConcept C163415756 @default.
• W3002452051 hasConcept C164705383 @default.
• W3002452051 hasConcept C24998067 @default.
• W3002452051 hasConcept C2777953023 @default.
• W3002452051 hasConcept C2778198053 @default.
• W3002452051 hasConcept C2780074459 @default.
• W3002452051 hasConcept C2780087125 @default.
• W3002452051 hasConcept C2780283014 @default.
• W3002452051 hasConcept C2781404750 @default.
• W3002452051 hasConcept C519063684 @default.
• W3002452051 hasConcept C71924100 @default.
• W3002452051 hasConcept C84393581 @default.
• W3002452051 hasConceptScore W3002452051C126322002 @default.
• W3002452051 hasConceptScore W3002452051C163415756 @default.
• W3002452051 hasConceptScore W3002452051C164705383 @default.
• W3002452051 hasConceptScore W3002452051C24998067 @default.
• W3002452051 hasConceptScore W3002452051C2777953023 @default.
• W3002452051 hasConceptScore W3002452051C2778198053 @default.
• W3002452051 hasConceptScore W3002452051C2780074459 @default.
• W3002452051 hasConceptScore W3002452051C2780087125 @default.
• W3002452051 hasConceptScore W3002452051C2780283014 @default.
• W3002452051 hasConceptScore W3002452051C2781404750 @default.
• W3002452051 hasConceptScore W3002452051C519063684 @default.
• W3002452051 hasConceptScore W3002452051C71924100 @default.
• W3002452051 hasConceptScore W3002452051C84393581 @default.
• W3002452051 hasFunder F4320307813 @default.
• W3002452051 hasFunder F4320319992 @default.
• W3002452051 hasFunder F4320324195 @default.
• W3002452051 hasIssue "2" @default.

• next