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- W3002453547 abstract "Abstract Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h 2 SNP ) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8–21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h 2 SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (−0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency." @default.
- W3002453547 created "2020-01-30" @default.
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- W3002453547 date "2020-01-21" @default.
- W3002453547 modified "2023-09-26" @default.
- W3002453547 title "Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth" @default.
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- W3002453547 doi "https://doi.org/10.1017/s0954579419001573" @default.
- W3002453547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7371534" @default.
- W3002453547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31959275" @default.
- W3002453547 hasPublicationYear "2020" @default.
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