FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002576278> ?p ?o ?g. }

• W3002576278 abstract "Systemic and quantitative investigations of human plasma proteins (proteomics) and Staphylococcus aureus-specific antibodies (immunoproteomics) provide complementary information and hold promise for the discovery of biomarkers in Staphylococcus aureus bloodstream infection (SABSI). Usually, data-dependent acquisition (DDA) is used for proteome analysis of serum or plasma, but data-independent acquisition (DIA) is more comprehensive and reproducible. In this prospective cohort study, we aimed to identify biomarkers associated with the early stages of SABSI using a serum DIA proteomic and immunoproteomic approach. Sera from 49 SABSI patients and 43 noninfected controls were analyzed. In total, 608 human serum proteins were identified with DIA. A total of 386 proteins could be quantified, of which 9 proteins, mainly belonging to acute-phase proteins, were significantly increased, while 7 high-density lipoproteins were lower in SABSI. In SABSI, total anti-S. aureus serum IgG was reduced compared with controls as shown by immunoproteomic quantification of IgG binding to 143 S. aureus antigens. IgG binding to 48 of these anti-S. aureus proteins was significantly lower in SABSI, while anti-Ecb IgG was the only one increased in SABSI. Serum IgG binding to autoinducing peptide MsrB, FadB, EsxA, Pbp2, FadB, SspB, or SodA was very low in SABSI. This marker panel discriminated early SABSI from controls with 95% sensitivity and 100% specificity according to random forest prediction. This holds promise for patient stratification according to their risk of S. aureus infection, underlines the protective function of the adaptive immune system, and encourages further efforts in the development of a vaccine against S. aureusIMPORTANCES. aureus sepsis has a high complication and mortality rate. Given the limited therapeutic possibilities, effective prevention strategies, e.g., a vaccine, or the early identification of high-risk patients would be important but are not available. Our study showed an acute-phase response in patients with S. aureus bloodstream infection and evidence that lipoproteins are downregulated in plasma. Using immunoproteomics, stratification of patients appears to be achievable, since at the early stages of systemic S. aureus infection patients had low preexisting anti-S. aureus antibody levels. This strengthens the notion that a robust immune memory for S. aureus protects against infections with the pathogen." @default.
• W3002576278 created "2020-01-30" @default.
• W3002576278 creator A5008605585 @default.
• W3002576278 creator A5015476234 @default.
• W3002576278 creator A5026939068 @default.
• W3002576278 creator A5045874625 @default.
• W3002576278 creator A5066171958 @default.
• W3002576278 creator A5081073059 @default.
• W3002576278 creator A5085641552 @default.
• W3002576278 creator A5085667735 @default.
• W3002576278 date "2020-02-11" @default.
• W3002576278 modified "2023-10-18" @default.
• W3002576278 title "Early-Stage <i>Staphylococcus aureus</i> Bloodstream Infection Causes Changes in the Concentrations of Lipoproteins and Acute-Phase Proteins and Is Associated with Low Antibody Titers against Bacterial Virulence Factors" @default.
• W3002576278 cites W1659186918 @default.
• W3002576278 cites W1789064953 @default.
• W3002576278 cites W1920613178 @default.
• W3002576278 cites W1965929258 @default.
• W3002576278 cites W1968557789 @default.
• W3002576278 cites W1969341196 @default.
• W3002576278 cites W1969463403 @default.
• W3002576278 cites W1970783326 @default.
• W3002576278 cites W1973468590 @default.
• W3002576278 cites W1989142603 @default.
• W3002576278 cites W1992690634 @default.
• W3002576278 cites W1993397663 @default.
• W3002576278 cites W1997599955 @default.
• W3002576278 cites W2010637514 @default.
• W3002576278 cites W2013191060 @default.
• W3002576278 cites W2017870685 @default.
• W3002576278 cites W2034910531 @default.
• W3002576278 cites W2035585086 @default.
• W3002576278 cites W2053922737 @default.
• W3002576278 cites W2062143232 @default.
• W3002576278 cites W2062859898 @default.
• W3002576278 cites W2072608250 @default.
• W3002576278 cites W2081465448 @default.
• W3002576278 cites W2081947485 @default.
• W3002576278 cites W2087203965 @default.
• W3002576278 cites W2096137537 @default.
• W3002576278 cites W2096643835 @default.
• W3002576278 cites W2098013607 @default.
• W3002576278 cites W2098533519 @default.
• W3002576278 cites W2101690239 @default.
• W3002576278 cites W2102187963 @default.
• W3002576278 cites W2102239923 @default.
• W3002576278 cites W2103534079 @default.
• W3002576278 cites W2121348586 @default.
• W3002576278 cites W2127585723 @default.
• W3002576278 cites W2128329047 @default.
• W3002576278 cites W2131219727 @default.
• W3002576278 cites W2139163053 @default.
• W3002576278 cites W2139294087 @default.
• W3002576278 cites W2139968030 @default.
• W3002576278 cites W2153947402 @default.
• W3002576278 cites W2154227961 @default.
• W3002576278 cites W2161881689 @default.
• W3002576278 cites W2162052530 @default.
• W3002576278 cites W2162103974 @default.
• W3002576278 cites W2162792752 @default.
• W3002576278 cites W2167665502 @default.
• W3002576278 cites W2169893082 @default.
• W3002576278 cites W2258871062 @default.
• W3002576278 cites W2292981964 @default.
• W3002576278 cites W2318873727 @default.
• W3002576278 cites W2330028620 @default.
• W3002576278 cites W2419335772 @default.
• W3002576278 cites W2421302446 @default.
• W3002576278 cites W2471439844 @default.
• W3002576278 cites W2477446061 @default.
• W3002576278 cites W2484035694 @default.
• W3002576278 cites W2574893599 @default.
• W3002576278 cites W2588349804 @default.
• W3002576278 cites W2610156696 @default.
• W3002576278 cites W2737554657 @default.
• W3002576278 cites W2751895478 @default.
• W3002576278 cites W2759363431 @default.
• W3002576278 cites W2775586319 @default.
• W3002576278 cites W2780046448 @default.
• W3002576278 cites W2798105113 @default.
• W3002576278 cites W2800936887 @default.
• W3002576278 cites W2807854357 @default.
• W3002576278 cites W2894307443 @default.
• W3002576278 cites W2912990441 @default.
• W3002576278 cites W4231506893 @default.
• W3002576278 cites W4254687493 @default.
• W3002576278 doi "https://doi.org/10.1128/msystems.00632-19" @default.
• W3002576278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6977072" @default.
• W3002576278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31964768" @default.
• W3002576278 hasPublicationYear "2020" @default.
• W3002576278 type Work @default.
• W3002576278 sameAs 3002576278 @default.
• W3002576278 citedByCount "7" @default.
• W3002576278 countsByYear W30025762782020 @default.
• W3002576278 countsByYear W30025762782021 @default.
• W3002576278 countsByYear W30025762782022 @default.
• W3002576278 countsByYear W30025762782023 @default.
• W3002576278 crossrefType "journal-article" @default.
• W3002576278 hasAuthorship W3002576278A5008605585 @default.
• W3002576278 hasAuthorship W3002576278A5015476234 @default.
• W3002576278 hasAuthorship W3002576278A5026939068 @default.

• next