Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002646516> ?p ?o ?g. }
- W3002646516 endingPage "321" @default.
- W3002646516 startingPage "321" @default.
- W3002646516 abstract "Chronic hepatitis B virus (HBV) infection is a serious public health issue. Vitamin D is involved in various pathophysiological mechanisms as an immune modulator and the deficiency rate of vitamin D is prevalent in chronic liver disease. Fucoidan exerts anti-inflammatory, anticoagulant, antitumor, antimetastatic, and antiangiogenetic effects; however, its effect on the immune responses of HBV patients is unclear. This study investigated how 25(OH)Vitamin D status affected the effectiveness of oligo fucoidan in patients with HBV infection in the immune tolerance phase. Fifty-one patients received oligo fucoidan 4400 mg/day for 48 weeks. Flow cytometry was used to detect T lymphocyte markers (CD3+CD4+, CD3+CD8+, CD4+CD45RO+, CD8+CD45RO+). The levels of white blood cell (WBC), platelets (PLT), and albumin were decreased after 48 weeks of supplementation (p < 0.05). Percentages of CD3+CD8+ and CD8+CD45RO+ cells were decreased after 12 weeks of supplementation (p < 0.05). In patients with adequate vitamin D, HBV-DNA concentrations decreased and the proportion of CD4+CD45RO+ and CD8+CD45RO+ cells increased upon oligo fucoidan supplementation. The HBeAg status of one vitamin D-adequate patient changed from positive to negative at the 12th week of supplementation. The oligo fucoidan may regulate immune effects in patients with HBV infection, and the 25(OH)Vitamin D status might have affected the effectiveness of oligo fucoidan." @default.
- W3002646516 created "2020-01-30" @default.
- W3002646516 creator A5004965863 @default.
- W3002646516 creator A5024451474 @default.
- W3002646516 creator A5049084106 @default.
- W3002646516 creator A5084649756 @default.
- W3002646516 date "2020-01-26" @default.
- W3002646516 modified "2023-09-30" @default.
- W3002646516 title "The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase" @default.
- W3002646516 cites W1531562094 @default.
- W3002646516 cites W1639675205 @default.
- W3002646516 cites W18136986 @default.
- W3002646516 cites W1893260165 @default.
- W3002646516 cites W1970315035 @default.
- W3002646516 cites W1980000062 @default.
- W3002646516 cites W1980703826 @default.
- W3002646516 cites W1988212011 @default.
- W3002646516 cites W1989961412 @default.
- W3002646516 cites W1999607993 @default.
- W3002646516 cites W2007020765 @default.
- W3002646516 cites W2024393140 @default.
- W3002646516 cites W2028365863 @default.
- W3002646516 cites W2044236152 @default.
- W3002646516 cites W2044951291 @default.
- W3002646516 cites W2059704818 @default.
- W3002646516 cites W2071267501 @default.
- W3002646516 cites W2071906618 @default.
- W3002646516 cites W2072226949 @default.
- W3002646516 cites W207768966 @default.
- W3002646516 cites W2079105341 @default.
- W3002646516 cites W2083924402 @default.
- W3002646516 cites W2084093881 @default.
- W3002646516 cites W2102139406 @default.
- W3002646516 cites W2107552769 @default.
- W3002646516 cites W2115114073 @default.
- W3002646516 cites W2119387393 @default.
- W3002646516 cites W2129739698 @default.
- W3002646516 cites W2131288162 @default.
- W3002646516 cites W2142657013 @default.
- W3002646516 cites W2147001117 @default.
- W3002646516 cites W2160176665 @default.
- W3002646516 cites W2167744756 @default.
- W3002646516 cites W2327229247 @default.
- W3002646516 cites W2418603513 @default.
- W3002646516 cites W2746016855 @default.
- W3002646516 cites W2754673346 @default.
- W3002646516 doi "https://doi.org/10.3390/nu12020321" @default.
- W3002646516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7071272" @default.
- W3002646516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31991892" @default.
- W3002646516 hasPublicationYear "2020" @default.
- W3002646516 type Work @default.
- W3002646516 sameAs 3002646516 @default.
- W3002646516 citedByCount "3" @default.
- W3002646516 countsByYear W30026465162021 @default.
- W3002646516 countsByYear W30026465162022 @default.
- W3002646516 countsByYear W30026465162023 @default.
- W3002646516 crossrefType "journal-article" @default.
- W3002646516 hasAuthorship W3002646516A5004965863 @default.
- W3002646516 hasAuthorship W3002646516A5024451474 @default.
- W3002646516 hasAuthorship W3002646516A5049084106 @default.
- W3002646516 hasAuthorship W3002646516A5084649756 @default.
- W3002646516 hasBestOaLocation W30026465161 @default.
- W3002646516 hasConcept C100817775 @default.
- W3002646516 hasConcept C124490489 @default.
- W3002646516 hasConcept C126322002 @default.
- W3002646516 hasConcept C167672396 @default.
- W3002646516 hasConcept C203014093 @default.
- W3002646516 hasConcept C2522874641 @default.
- W3002646516 hasConcept C2775909754 @default.
- W3002646516 hasConcept C2776940978 @default.
- W3002646516 hasConcept C2777761686 @default.
- W3002646516 hasConcept C2780593183 @default.
- W3002646516 hasConcept C55493867 @default.
- W3002646516 hasConcept C71924100 @default.
- W3002646516 hasConcept C86803240 @default.
- W3002646516 hasConcept C8891405 @default.
- W3002646516 hasConceptScore W3002646516C100817775 @default.
- W3002646516 hasConceptScore W3002646516C124490489 @default.
- W3002646516 hasConceptScore W3002646516C126322002 @default.
- W3002646516 hasConceptScore W3002646516C167672396 @default.
- W3002646516 hasConceptScore W3002646516C203014093 @default.
- W3002646516 hasConceptScore W3002646516C2522874641 @default.
- W3002646516 hasConceptScore W3002646516C2775909754 @default.
- W3002646516 hasConceptScore W3002646516C2776940978 @default.
- W3002646516 hasConceptScore W3002646516C2777761686 @default.
- W3002646516 hasConceptScore W3002646516C2780593183 @default.
- W3002646516 hasConceptScore W3002646516C55493867 @default.
- W3002646516 hasConceptScore W3002646516C71924100 @default.
- W3002646516 hasConceptScore W3002646516C86803240 @default.
- W3002646516 hasConceptScore W3002646516C8891405 @default.
- W3002646516 hasIssue "2" @default.
- W3002646516 hasLocation W30026465161 @default.
- W3002646516 hasLocation W30026465162 @default.
- W3002646516 hasLocation W30026465163 @default.
- W3002646516 hasLocation W30026465164 @default.
- W3002646516 hasOpenAccess W3002646516 @default.
- W3002646516 hasPrimaryLocation W30026465161 @default.
- W3002646516 hasRelatedWork W1506984959 @default.