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• W3002742953 endingPage "3287" @default.
• W3002742953 startingPage "3287" @default.
• W3002742953 abstract "Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developments and progress in technology. Natural compounds were shown to bear an inherent ability to bind to biomacromolecules and cover an unparalleled chemical space in comparison to most libraries used for high-throughput screening. Thus, natural products hold a great potential for the drug discovery of new scaffolds for therapeutic targets such as sirtuins. Sirtuins are Class III histone deacetylases that have been linked to many diseases such as Parkinson`s disease, Alzheimer’s disease, type II diabetes, and cancer linked to aging. In this review, we examine the revitalization of interest in natural products for drug discovery and discuss natural product modulators of sirtuins that could serve as a starting point for the development of isoform selective and highly potent drug-like compounds, as well as the potential application of naturally occurring sirtuin inhibitors in human health and those in clinical trials." @default.
• W3002742953 created "2020-01-30" @default.
• W3002742953 creator A5015062918 @default.
• W3002742953 creator A5055328126 @default.
• W3002742953 creator A5075505477 @default.
• W3002742953 date "2020-07-20" @default.
• W3002742953 modified "2023-10-12" @default.
• W3002742953 title "Natural Products as Modulators of Sirtuins" @default.
• W3002742953 cites W1482169712 @default.
• W3002742953 cites W1500036797 @default.
• W3002742953 cites W1565431211 @default.
• W3002742953 cites W1578795360 @default.
• W3002742953 cites W1606511543 @default.
• W3002742953 cites W1759122038 @default.
• W3002742953 cites W1777052256 @default.
• W3002742953 cites W1782536694 @default.
• W3002742953 cites W1862685904 @default.
• W3002742953 cites W1895993106 @default.
• W3002742953 cites W1907955248 @default.
• W3002742953 cites W1964296506 @default.
• W3002742953 cites W1965563015 @default.
• W3002742953 cites W1968105489 @default.
• W3002742953 cites W1969562732 @default.
• W3002742953 cites W1973639948 @default.
• W3002742953 cites W1973946414 @default.
• W3002742953 cites W1976674477 @default.
• W3002742953 cites W1977880285 @default.
• W3002742953 cites W1977964424 @default.
• W3002742953 cites W1978009405 @default.
• W3002742953 cites W1978190393 @default.
• W3002742953 cites W1978511426 @default.
• W3002742953 cites W1982728268 @default.
• W3002742953 cites W1986877326 @default.
• W3002742953 cites W1989141893 @default.
• W3002742953 cites W1989431509 @default.
• W3002742953 cites W1990226486 @default.
• W3002742953 cites W1992207445 @default.
• W3002742953 cites W1992823976 @default.
• W3002742953 cites W1995454209 @default.
• W3002742953 cites W2002393930 @default.
• W3002742953 cites W2003495522 @default.
• W3002742953 cites W2004120029 @default.
• W3002742953 cites W2006022142 @default.
• W3002742953 cites W2006137883 @default.
• W3002742953 cites W2007415161 @default.
• W3002742953 cites W2010336485 @default.
• W3002742953 cites W2010350443 @default.
• W3002742953 cites W2010519875 @default.
• W3002742953 cites W2011398127 @default.
• W3002742953 cites W2011916025 @default.
• W3002742953 cites W2012077091 @default.
• W3002742953 cites W2016060560 @default.
• W3002742953 cites W2018739566 @default.
• W3002742953 cites W2019435413 @default.
• W3002742953 cites W2019994199 @default.
• W3002742953 cites W2020513326 @default.
• W3002742953 cites W2021168357 @default.
• W3002742953 cites W2021631452 @default.
• W3002742953 cites W2022267544 @default.
• W3002742953 cites W2022435627 @default.
• W3002742953 cites W2022563440 @default.
• W3002742953 cites W2027112793 @default.
• W3002742953 cites W2027930781 @default.
• W3002742953 cites W2028165126 @default.
• W3002742953 cites W2028986035 @default.
• W3002742953 cites W2030373321 @default.
• W3002742953 cites W2031441006 @default.
• W3002742953 cites W2032986001 @default.
• W3002742953 cites W2033228549 @default.
• W3002742953 cites W2033897153 @default.
• W3002742953 cites W2034629671 @default.
• W3002742953 cites W2036733327 @default.
• W3002742953 cites W2037723157 @default.
• W3002742953 cites W2037863187 @default.
• W3002742953 cites W2038264047 @default.
• W3002742953 cites W2038806961 @default.
• W3002742953 cites W2041016831 @default.
• W3002742953 cites W2041724483 @default.
• W3002742953 cites W2044115882 @default.
• W3002742953 cites W2044767846 @default.
• W3002742953 cites W2048848795 @default.
• W3002742953 cites W2049592294 @default.
• W3002742953 cites W2053935131 @default.
• W3002742953 cites W2054670968 @default.
• W3002742953 cites W2055237220 @default.
• W3002742953 cites W2055519118 @default.
• W3002742953 cites W2056564149 @default.
• W3002742953 cites W2057612709 @default.
• W3002742953 cites W2058819387 @default.
• W3002742953 cites W2060911111 @default.
• W3002742953 cites W2062219625 @default.
• W3002742953 cites W2063688418 @default.
• W3002742953 cites W2065377428 @default.
• W3002742953 cites W2067517027 @default.
• W3002742953 cites W2068289009 @default.
• W3002742953 cites W2069302307 @default.
• W3002742953 cites W2069423751 @default.
• W3002742953 cites W2073860212 @default.

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