Matches in SemOpenAlex for { <https://semopenalex.org/work/W3002847871> ?p ?o ?g. }
- W3002847871 endingPage "4292" @default.
- W3002847871 startingPage "4283" @default.
- W3002847871 abstract "The environmental hypoxia of high altitude (HA) increases the incidence of intrauterine growth restriction (IUGR) approximately threefold. The peroxisome proliferator-activated receptor γ (PPAR-γ), a ligand-activated nuclear receptor that promotes vasorelaxation by increasing nitric oxide and downregulating endothelin-1 (ET-1) production, has been implicated in IUGR. Based on our prior work indicating that pharmacologic activation of the PPARγ pathway protects against hypoxia-associated IUGR, we used an experimental murine model to determine whether such effects may be attributed to vasodilatory effects in the uteroplacental circulation. Using wire myography, ex vivo vasoreactivity studies were conducted in uterine arteries (UtA) isolated from pregnant mice exposed to hypoxia or normoxia from gestational day 14.5 to 18.5. Exposure to troglitazone, a high-affinity PPARγ agonist-induced vasorelaxation in UtA preconstricted with phenylephrine, with HA-UtA showing increased sensitivity. Troglitazone blunted ET-1-induced contraction of UtA in hypoxic and normoxic dams equivalently. Immunohistological analysis revealed enhanced staining for ET-1 receptors in the placental labyrinthine zone in hypoxic compared to normoxic dams. Our results suggest that pharmacologic PPAR-γ activation, via its vasoactive properties, may protect the fetal growth under hypoxic conditions by improving uteroplacental perfusion and thereby justify further investigation into PPARγ as a therapeutic target for IUGR in pregnancies complicated by hypoxia." @default.
- W3002847871 created "2020-01-30" @default.
- W3002847871 creator A5031352497 @default.
- W3002847871 creator A5057896688 @default.
- W3002847871 creator A5065455714 @default.
- W3002847871 creator A5068008710 @default.
- W3002847871 creator A5068543970 @default.
- W3002847871 creator A5079810847 @default.
- W3002847871 creator A5089562312 @default.
- W3002847871 date "2020-01-23" @default.
- W3002847871 modified "2023-09-25" @default.
- W3002847871 title "Peroxisome proliferator‐activated receptor gamma blunts endothelin‐1‐mediated contraction of the uterine artery in a murine model of high‐altitude pregnancy" @default.
- W3002847871 cites W1037845154 @default.
- W3002847871 cites W1490068297 @default.
- W3002847871 cites W1633340712 @default.
- W3002847871 cites W1639924204 @default.
- W3002847871 cites W1799342040 @default.
- W3002847871 cites W1895232527 @default.
- W3002847871 cites W1906865331 @default.
- W3002847871 cites W1967667786 @default.
- W3002847871 cites W1970999549 @default.
- W3002847871 cites W1977071886 @default.
- W3002847871 cites W1978320715 @default.
- W3002847871 cites W1983890824 @default.
- W3002847871 cites W1984778513 @default.
- W3002847871 cites W1988848089 @default.
- W3002847871 cites W1992740479 @default.
- W3002847871 cites W1999742888 @default.
- W3002847871 cites W2000378161 @default.
- W3002847871 cites W2004423054 @default.
- W3002847871 cites W2007226687 @default.
- W3002847871 cites W2010220662 @default.
- W3002847871 cites W2011840626 @default.
- W3002847871 cites W2014784119 @default.
- W3002847871 cites W2024000600 @default.
- W3002847871 cites W2035455652 @default.
- W3002847871 cites W2037885071 @default.
- W3002847871 cites W2039458448 @default.
- W3002847871 cites W2040558778 @default.
- W3002847871 cites W2046532245 @default.
- W3002847871 cites W2051061036 @default.
- W3002847871 cites W2052092988 @default.
- W3002847871 cites W2056919530 @default.
- W3002847871 cites W2059725369 @default.
- W3002847871 cites W2063438389 @default.
- W3002847871 cites W2072727898 @default.
- W3002847871 cites W2073578030 @default.
- W3002847871 cites W2073963593 @default.
- W3002847871 cites W2083239187 @default.
- W3002847871 cites W2088542426 @default.
- W3002847871 cites W2110804432 @default.
- W3002847871 cites W2110928305 @default.
- W3002847871 cites W2112959275 @default.
- W3002847871 cites W2119617266 @default.
- W3002847871 cites W2127355819 @default.
- W3002847871 cites W2128790473 @default.
- W3002847871 cites W2136048699 @default.
- W3002847871 cites W2142359591 @default.
- W3002847871 cites W2144889596 @default.
- W3002847871 cites W2145277495 @default.
- W3002847871 cites W2151389745 @default.
- W3002847871 cites W2153095749 @default.
- W3002847871 cites W2153290552 @default.
- W3002847871 cites W2166117052 @default.
- W3002847871 cites W2170071143 @default.
- W3002847871 cites W2171533490 @default.
- W3002847871 cites W2173045762 @default.
- W3002847871 cites W2198955773 @default.
- W3002847871 cites W2274836352 @default.
- W3002847871 cites W2278794227 @default.
- W3002847871 cites W2410251762 @default.
- W3002847871 cites W2415399249 @default.
- W3002847871 cites W2533165820 @default.
- W3002847871 cites W2940484460 @default.
- W3002847871 cites W2942680836 @default.
- W3002847871 cites W4231360207 @default.
- W3002847871 cites W4236897356 @default.
- W3002847871 cites W4248638442 @default.
- W3002847871 cites W4253883553 @default.
- W3002847871 doi "https://doi.org/10.1096/fj.201902264rr" @default.
- W3002847871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7060097" @default.
- W3002847871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31970838" @default.
- W3002847871 hasPublicationYear "2020" @default.
- W3002847871 type Work @default.
- W3002847871 sameAs 3002847871 @default.
- W3002847871 citedByCount "2" @default.
- W3002847871 countsByYear W30028478712021 @default.
- W3002847871 countsByYear W30028478712022 @default.
- W3002847871 crossrefType "journal-article" @default.
- W3002847871 hasAuthorship W3002847871A5031352497 @default.
- W3002847871 hasAuthorship W3002847871A5057896688 @default.
- W3002847871 hasAuthorship W3002847871A5065455714 @default.
- W3002847871 hasAuthorship W3002847871A5068008710 @default.
- W3002847871 hasAuthorship W3002847871A5068543970 @default.
- W3002847871 hasAuthorship W3002847871A5079810847 @default.
- W3002847871 hasAuthorship W3002847871A5089562312 @default.
- W3002847871 hasBestOaLocation W30028478711 @default.
- W3002847871 hasConcept C120770815 @default.