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- W3003005816 abstract "Objectives Osteoarthritis (OA) is known to be a slowly progressive disease that alters all tissue compartments of the joint involved with a characteristic degradation of the cartilage, bone remodeling, and inflammation. One of the prominent symptoms in OA patients is pain, but a few radiologic, inflammatory, or structurally related biomarkers have shown few if any associations with pain. This study aimed to assess serum levels of 92 markers involved in inflammatory pathways in patients with knee osteoarthritis (KOA) and evaluate their possible associations with the clinical pain intensity. Materials and methods Serum samples were collected from 127 KOA patients and 39 healthy participants with no knee pain. Each serum sample was analyzed for 92 inflammatory markers using the Proximity Extension Array (PEA) technology. Clinical pain intensity was assessed using a Visual Analog Scale, and patients completed the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. Results Fifteen markers were significantly different when comparing KOA patients and healthy participants. Two markers, fibroblast growth factor-21 and Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), correlated positively with pain intensity (R=0.235, P=0.008; R=0.233, P=0.008). Moreover, a linear regression model showed interleukin-6, macrophage colony-stimulating factor 1, fibroblast growth factor-21, and tumor necrosis factor superfamily member 12 (TWEAK) as significant independent parameters for pain intensity. Discussion The associations between specific cytokines and KOA pain intensities provide new insights into the understanding of the underlying factors driving the pain in OA." @default.
- W3003005816 created "2020-01-30" @default.
- W3003005816 creator A5012149482 @default.
- W3003005816 creator A5016157357 @default.
- W3003005816 creator A5078339011 @default.
- W3003005816 creator A5082271937 @default.
- W3003005816 creator A5085497734 @default.
- W3003005816 date "2020-01-16" @default.
- W3003005816 modified "2023-09-30" @default.
- W3003005816 title "Serum Inflammatory Markers in Patients With Knee Osteoarthritis" @default.
- W3003005816 cites W1520309076 @default.
- W3003005816 cites W1578200675 @default.
- W3003005816 cites W1718779047 @default.
- W3003005816 cites W1965665343 @default.
- W3003005816 cites W1967057044 @default.
- W3003005816 cites W1967276782 @default.
- W3003005816 cites W1968796843 @default.
- W3003005816 cites W1969223758 @default.
- W3003005816 cites W1980360785 @default.
- W3003005816 cites W1983068219 @default.
- W3003005816 cites W1987155536 @default.
- W3003005816 cites W1989013208 @default.
- W3003005816 cites W1992727606 @default.
- W3003005816 cites W2000770184 @default.
- W3003005816 cites W2000873101 @default.
- W3003005816 cites W2010084870 @default.
- W3003005816 cites W2017471543 @default.
- W3003005816 cites W2018463433 @default.
- W3003005816 cites W2019799652 @default.
- W3003005816 cites W2022136169 @default.
- W3003005816 cites W2022385761 @default.
- W3003005816 cites W2024725966 @default.
- W3003005816 cites W2027831505 @default.
- W3003005816 cites W2028178274 @default.
- W3003005816 cites W2028834304 @default.
- W3003005816 cites W2032267692 @default.
- W3003005816 cites W2033170387 @default.
- W3003005816 cites W2038773696 @default.
- W3003005816 cites W2039248606 @default.
- W3003005816 cites W2044397895 @default.
- W3003005816 cites W2044953211 @default.
- W3003005816 cites W2045733786 @default.
- W3003005816 cites W2046296795 @default.
- W3003005816 cites W2046645100 @default.
- W3003005816 cites W2051032088 @default.
- W3003005816 cites W2055167420 @default.
- W3003005816 cites W2061538346 @default.
- W3003005816 cites W2062462227 @default.
- W3003005816 cites W2063391683 @default.
- W3003005816 cites W2063680739 @default.
- W3003005816 cites W2066659898 @default.
- W3003005816 cites W2066972887 @default.
- W3003005816 cites W2068864388 @default.
- W3003005816 cites W2076339051 @default.
- W3003005816 cites W2078828283 @default.
- W3003005816 cites W2078850432 @default.
- W3003005816 cites W2092413554 @default.
- W3003005816 cites W2097529453 @default.
- W3003005816 cites W2098462847 @default.
- W3003005816 cites W2098776090 @default.
- W3003005816 cites W2101637120 @default.
- W3003005816 cites W2107908226 @default.
- W3003005816 cites W2110598751 @default.
- W3003005816 cites W2111913995 @default.
- W3003005816 cites W2112870271 @default.
- W3003005816 cites W2113670619 @default.
- W3003005816 cites W2116576448 @default.
- W3003005816 cites W2117674849 @default.
- W3003005816 cites W2123500931 @default.
- W3003005816 cites W2129585918 @default.
- W3003005816 cites W2131578075 @default.
- W3003005816 cites W2134175790 @default.
- W3003005816 cites W2135649915 @default.
- W3003005816 cites W2138955957 @default.
- W3003005816 cites W2142911981 @default.
- W3003005816 cites W2142941764 @default.
- W3003005816 cites W2157887795 @default.
- W3003005816 cites W2158866061 @default.
- W3003005816 cites W2166954629 @default.
- W3003005816 cites W2178057896 @default.
- W3003005816 cites W2190814680 @default.
- W3003005816 cites W2206012323 @default.
- W3003005816 cites W2274686281 @default.
- W3003005816 cites W2277544136 @default.
- W3003005816 cites W2302378285 @default.
- W3003005816 cites W2323113905 @default.
- W3003005816 cites W2336631222 @default.
- W3003005816 cites W2338975497 @default.
- W3003005816 cites W2370677464 @default.
- W3003005816 cites W2566211026 @default.
- W3003005816 cites W2587499203 @default.
- W3003005816 cites W2613386636 @default.
- W3003005816 cites W2625114998 @default.
- W3003005816 cites W2771279768 @default.
- W3003005816 cites W2771516164 @default.
- W3003005816 cites W2783663085 @default.
- W3003005816 cites W2886823250 @default.
- W3003005816 cites W2887570178 @default.