Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003067652> ?p ?o ?g. }
- W3003067652 endingPage "167" @default.
- W3003067652 startingPage "158" @default.
- W3003067652 abstract "Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have emerged to combat this deadly cancer, the 5-year survival rate has plateaued over the past four decades. Therapeutic progress has been notably poor because past technologies have not been able to reveal obscured OS biomarkers and targets. With the advent and implementation of large-scale next-generation sequencing (NGS) studies, various somatic mutations and copy number changes involved in OS progression and metastasis have surfaced. These findings have significantly expanded the amount of genome-informed pathways and candidate genes suitable for targeting in pre-clinical models. Furthermore, NGS analyses comparing primary and matched pulmonary metastatic tumor tissues have catalogued previously unknown prognostic biomarkers in OS. In this review, we delineate the most recent findings in NGS for OS therapy and how this technology has advanced personalized therapy." @default.
- W3003067652 created "2020-01-30" @default.
- W3003067652 creator A5009665768 @default.
- W3003067652 creator A5038077156 @default.
- W3003067652 creator A5055817420 @default.
- W3003067652 creator A5069467749 @default.
- W3003067652 creator A5080785809 @default.
- W3003067652 date "2020-04-01" @default.
- W3003067652 modified "2023-09-29" @default.
- W3003067652 title "Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy" @default.
- W3003067652 cites W1159008209 @default.
- W3003067652 cites W1540759505 @default.
- W3003067652 cites W1547298604 @default.
- W3003067652 cites W1560058309 @default.
- W3003067652 cites W165597557 @default.
- W3003067652 cites W1759847609 @default.
- W3003067652 cites W1900190441 @default.
- W3003067652 cites W1914608195 @default.
- W3003067652 cites W1922287515 @default.
- W3003067652 cites W1941647266 @default.
- W3003067652 cites W1954845453 @default.
- W3003067652 cites W1964756237 @default.
- W3003067652 cites W1965856472 @default.
- W3003067652 cites W1967232576 @default.
- W3003067652 cites W1969313893 @default.
- W3003067652 cites W1981509058 @default.
- W3003067652 cites W1983171715 @default.
- W3003067652 cites W1984208675 @default.
- W3003067652 cites W1987380414 @default.
- W3003067652 cites W1994586297 @default.
- W3003067652 cites W1995063759 @default.
- W3003067652 cites W1998627464 @default.
- W3003067652 cites W2002121944 @default.
- W3003067652 cites W2002993576 @default.
- W3003067652 cites W2003869969 @default.
- W3003067652 cites W2003946870 @default.
- W3003067652 cites W2005802066 @default.
- W3003067652 cites W2010256904 @default.
- W3003067652 cites W2010626193 @default.
- W3003067652 cites W2013320864 @default.
- W3003067652 cites W2017060505 @default.
- W3003067652 cites W2021307865 @default.
- W3003067652 cites W2022495797 @default.
- W3003067652 cites W2033889422 @default.
- W3003067652 cites W2038631479 @default.
- W3003067652 cites W2044332600 @default.
- W3003067652 cites W2050723856 @default.
- W3003067652 cites W2056445663 @default.
- W3003067652 cites W2057370954 @default.
- W3003067652 cites W2076424556 @default.
- W3003067652 cites W2084821192 @default.
- W3003067652 cites W2085302318 @default.
- W3003067652 cites W2086555066 @default.
- W3003067652 cites W2087582057 @default.
- W3003067652 cites W2095885501 @default.
- W3003067652 cites W2099742439 @default.
- W3003067652 cites W2102140136 @default.
- W3003067652 cites W2115160785 @default.
- W3003067652 cites W2118151336 @default.
- W3003067652 cites W2121906867 @default.
- W3003067652 cites W2123745849 @default.
- W3003067652 cites W2124624913 @default.
- W3003067652 cites W2127063807 @default.
- W3003067652 cites W2127748864 @default.
- W3003067652 cites W2129504003 @default.
- W3003067652 cites W2129904582 @default.
- W3003067652 cites W2131259026 @default.
- W3003067652 cites W2134433047 @default.
- W3003067652 cites W2140360759 @default.
- W3003067652 cites W2141637710 @default.
- W3003067652 cites W2142834543 @default.
- W3003067652 cites W2146496799 @default.
- W3003067652 cites W2153056550 @default.
- W3003067652 cites W2155393958 @default.
- W3003067652 cites W2160444236 @default.
- W3003067652 cites W2161106528 @default.
- W3003067652 cites W2164693455 @default.
- W3003067652 cites W2167348613 @default.
- W3003067652 cites W2168808367 @default.
- W3003067652 cites W2176699305 @default.
- W3003067652 cites W2192272998 @default.
- W3003067652 cites W2213752852 @default.
- W3003067652 cites W2262236353 @default.
- W3003067652 cites W2291974750 @default.
- W3003067652 cites W2295971206 @default.
- W3003067652 cites W2323982005 @default.
- W3003067652 cites W2341128841 @default.
- W3003067652 cites W2395783098 @default.
- W3003067652 cites W2467559786 @default.
- W3003067652 cites W2536732763 @default.
- W3003067652 cites W2614443510 @default.
- W3003067652 cites W2671688469 @default.
- W3003067652 cites W2747989445 @default.
- W3003067652 cites W2752942423 @default.
- W3003067652 cites W2765217312 @default.
- W3003067652 cites W2765825216 @default.
- W3003067652 cites W2769376743 @default.
- W3003067652 cites W2772062014 @default.