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- W3003071079 endingPage "261" @default.
- W3003071079 startingPage "235" @default.
- W3003071079 abstract "Abstract The fibroblast growth factor receptor family and their ligands regulate cell proliferation, invasion, and numerous other pathways essential for tumorigenesis. Aberrations in FGFRs have been reported to activate signaling pathways involved in cell survival and therapy resistance in tumors, thereby making FGFRs notable therapeutic targets. In head and neck squamous cell carcinomas (HNSCC) FGFR expression and FGFR1 amplification are associated with invasive disease, increased aggressiveness of disease, and poor overall survival. FGFR inhibition in HNSCC has demonstrated strong in vitro efficacy. The few clinical trials that have been reported suggest that FGFR inhibition can lead to tumor shrinkage. Multiple studies have found that FGFR-inhibition helps overcome therapeutic resistance to current standard of care therapies. The role of the FGFRs as therapeutic targets and biomarkers in HNSCC will be discussed in this chapter. We will highlight pre-clinical and clinical studies that investigate FGFR inhibition as a means for enhancing antitumor effects in HNSCC." @default.
- W3003071079 created "2020-01-30" @default.
- W3003071079 creator A5023121753 @default.
- W3003071079 creator A5028980866 @default.
- W3003071079 creator A5041234276 @default.
- W3003071079 date "2020-01-01" @default.
- W3003071079 modified "2023-09-23" @default.
- W3003071079 title "Fibroblast growth factor receptors as therapeutic targets in head and neck squamous cell carcinomas" @default.
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