Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003149341> ?p ?o ?g. }
- W3003149341 endingPage "e0228000" @default.
- W3003149341 startingPage "e0228000" @default.
- W3003149341 abstract "Interethnic variability in drug response arises from genetic differences associated with drug metabolism, action and transport. These genetic variations can affect drug efficacy as well as cause adverse drug reactions (ADRs). We retrieved drug-response related single nucleotide polymorphism (SNP) associated data from databases and analyzed to elucidate population specific distribution of 159 drug-response related SNPs in twenty six populations belonging to five super-populations (African, Admixed Americans, East Asian, European and South Asian). Significant interpopulation differences exist in the minor (variant) allele frequencies (MAFs), linkage disequilibrium (LD) and haplotype distributions among these populations. 65 of the drug-response related alleles, which are considered as minor (variant) in global population, are present as the major alleles (frequency ≥0.5) in at least one or more populations. Populations that belong to the same super-population have similar distribution pattern for majority of the variant alleles. These drug response related variant allele frequencies and their pairwise LD measure (r2) can clearly distinguish the populations in a way that correspond to the known evolutionary history of human and current geographic distributions, while D' cannot. The data presented here may aid in identifying drugs that are more appropriate and/or require pharmacogenetic testing in these populations. Our findings emphasize on the importance of distinct, ethnicity-specific clinical guidelines, especially for the African populations, to avoid ADRs and ensure effective drug treatment." @default.
- W3003149341 created "2020-01-30" @default.
- W3003149341 creator A5020167215 @default.
- W3003149341 creator A5023218013 @default.
- W3003149341 creator A5063175922 @default.
- W3003149341 date "2020-01-23" @default.
- W3003149341 modified "2023-10-18" @default.
- W3003149341 title "Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness" @default.
- W3003149341 cites W1548815298 @default.
- W3003149341 cites W1731716450 @default.
- W3003149341 cites W1763433851 @default.
- W3003149341 cites W1804951357 @default.
- W3003149341 cites W1887737698 @default.
- W3003149341 cites W1966253403 @default.
- W3003149341 cites W1967783003 @default.
- W3003149341 cites W1968004796 @default.
- W3003149341 cites W1969879564 @default.
- W3003149341 cites W1974748046 @default.
- W3003149341 cites W1979046034 @default.
- W3003149341 cites W1981283697 @default.
- W3003149341 cites W1982185581 @default.
- W3003149341 cites W1982733535 @default.
- W3003149341 cites W1984224132 @default.
- W3003149341 cites W1986879540 @default.
- W3003149341 cites W1989695882 @default.
- W3003149341 cites W1991925547 @default.
- W3003149341 cites W1993188977 @default.
- W3003149341 cites W1994171421 @default.
- W3003149341 cites W1996069708 @default.
- W3003149341 cites W1998283760 @default.
- W3003149341 cites W1999988283 @default.
- W3003149341 cites W2002026305 @default.
- W3003149341 cites W2007531498 @default.
- W3003149341 cites W2012533831 @default.
- W3003149341 cites W2022321262 @default.
- W3003149341 cites W2024027525 @default.
- W3003149341 cites W2027339324 @default.
- W3003149341 cites W2037336322 @default.
- W3003149341 cites W2044375939 @default.
- W3003149341 cites W2045368807 @default.
- W3003149341 cites W2045976476 @default.
- W3003149341 cites W2046057128 @default.
- W3003149341 cites W2049658450 @default.
- W3003149341 cites W2057287618 @default.
- W3003149341 cites W2061826745 @default.
- W3003149341 cites W2062584673 @default.
- W3003149341 cites W2063280109 @default.
- W3003149341 cites W2064337222 @default.
- W3003149341 cites W2066474535 @default.
- W3003149341 cites W2068149117 @default.
- W3003149341 cites W2075283257 @default.
- W3003149341 cites W2083461328 @default.
- W3003149341 cites W2085947779 @default.
- W3003149341 cites W2091128031 @default.
- W3003149341 cites W2093044565 @default.
- W3003149341 cites W2095829498 @default.
- W3003149341 cites W2099466163 @default.
- W3003149341 cites W2099527353 @default.
- W3003149341 cites W2100434774 @default.
- W3003149341 cites W2101307264 @default.
- W3003149341 cites W2102714321 @default.
- W3003149341 cites W2103176059 @default.
- W3003149341 cites W2104549677 @default.
- W3003149341 cites W2106814405 @default.
- W3003149341 cites W2107579814 @default.
- W3003149341 cites W2109956641 @default.
- W3003149341 cites W2112602049 @default.
- W3003149341 cites W2112990925 @default.
- W3003149341 cites W2119228812 @default.
- W3003149341 cites W2119616168 @default.
- W3003149341 cites W2121034252 @default.
- W3003149341 cites W2123710605 @default.
- W3003149341 cites W2124342855 @default.
- W3003149341 cites W2127362327 @default.
- W3003149341 cites W2129316818 @default.
- W3003149341 cites W2129624521 @default.
- W3003149341 cites W2130348423 @default.
- W3003149341 cites W2130474364 @default.
- W3003149341 cites W2131319167 @default.
- W3003149341 cites W2133540218 @default.
- W3003149341 cites W2138843850 @default.
- W3003149341 cites W2140026462 @default.
- W3003149341 cites W2141179727 @default.
- W3003149341 cites W2148476745 @default.
- W3003149341 cites W2154866190 @default.
- W3003149341 cites W2160947832 @default.
- W3003149341 cites W2162301803 @default.
- W3003149341 cites W2164705071 @default.
- W3003149341 cites W2166320441 @default.
- W3003149341 cites W2166925937 @default.
- W3003149341 cites W2189079163 @default.
- W3003149341 cites W2213256118 @default.
- W3003149341 cites W2228893697 @default.
- W3003149341 cites W2235493209 @default.
- W3003149341 cites W2287087292 @default.
- W3003149341 cites W2325443153 @default.
- W3003149341 cites W2336729711 @default.
- W3003149341 cites W2346441949 @default.