Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003155131> ?p ?o ?g. }
- W3003155131 abstract "Summary The role of germline genetics in shaping the tumor immune landscape is largely unknown. Using genotypes from >9,000 individuals in The Cancer Genome Atlas, we investigated the association of common and rare variants with 139 well-defined immune traits. Our analysis of common variants identified 10 immune traits with significant heritability estimates, and an additional 23 with suggestive heritability, including estimates of T-cell subset abundance and interferon signaling. We performed genome-wide association on the 33 heritable traits and identified 23 genome-wide significant loci associated with at least one immune trait, including SNPs in the IFIH1 locus previously associated with several autoimmune diseases. We also found significant associations between immune traits and pathogenic or likely-pathogenic rare variants in BRCA1 and in genes functionally linked to telomere stabilization, and Wnt/Beta-catenin signaling. We conclude that germline genetic variants significantly impact the composition and functional orientation of the tumor immune microenvironment." @default.
- W3003155131 created "2020-02-07" @default.
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- W3003155131 date "2020-01-31" @default.
- W3003155131 modified "2023-10-16" @default.
- W3003155131 title "Germline genetic contribution to the immune landscape of cancer" @default.
- W3003155131 cites W1014257459 @default.
- W3003155131 cites W1107917109 @default.
- W3003155131 cites W1498931318 @default.
- W3003155131 cites W1940241680 @default.
- W3003155131 cites W1966107523 @default.
- W3003155131 cites W1967896668 @default.
- W3003155131 cites W1967954493 @default.
- W3003155131 cites W1990270625 @default.
- W3003155131 cites W1992468678 @default.
- W3003155131 cites W2013274313 @default.
- W3003155131 cites W2018369441 @default.
- W3003155131 cites W2033151532 @default.
- W3003155131 cites W2034046719 @default.
- W3003155131 cites W2039123767 @default.
- W3003155131 cites W2045949302 @default.
- W3003155131 cites W2073062251 @default.
- W3003155131 cites W2090347584 @default.
- W3003155131 cites W2098380237 @default.
- W3003155131 cites W2099085143 @default.
- W3003155131 cites W2100665873 @default.
- W3003155131 cites W2102889851 @default.
- W3003155131 cites W2103532849 @default.
- W3003155131 cites W2104636614 @default.
- W3003155131 cites W2104885590 @default.
- W3003155131 cites W2105133921 @default.
- W3003155131 cites W2105595774 @default.
- W3003155131 cites W2107429737 @default.
- W3003155131 cites W2111307685 @default.
- W3003155131 cites W2117692326 @default.
- W3003155131 cites W2123423918 @default.
- W3003155131 cites W2131889332 @default.
- W3003155131 cites W2132923173 @default.
- W3003155131 cites W2135207654 @default.
- W3003155131 cites W2142300779 @default.
- W3003155131 cites W2145825942 @default.
- W3003155131 cites W2155496693 @default.
- W3003155131 cites W2156906256 @default.
- W3003155131 cites W2159182432 @default.
- W3003155131 cites W2163013660 @default.
- W3003155131 cites W2163104142 @default.
- W3003155131 cites W2163461790 @default.
- W3003155131 cites W2263101679 @default.
- W3003155131 cites W2295989008 @default.
- W3003155131 cites W2299919100 @default.
- W3003155131 cites W2413234541 @default.
- W3003155131 cites W2469213152 @default.
- W3003155131 cites W2511515754 @default.
- W3003155131 cites W2524088453 @default.
- W3003155131 cites W2529241974 @default.
- W3003155131 cites W2546709910 @default.
- W3003155131 cites W2573601812 @default.
- W3003155131 cites W2574604975 @default.
- W3003155131 cites W2578528809 @default.
- W3003155131 cites W2586710091 @default.
- W3003155131 cites W2596312543 @default.
- W3003155131 cites W2596337597 @default.
- W3003155131 cites W2601558386 @default.
- W3003155131 cites W2606528726 @default.
- W3003155131 cites W2611279418 @default.
- W3003155131 cites W2612805962 @default.
- W3003155131 cites W2622499649 @default.
- W3003155131 cites W2655262992 @default.
- W3003155131 cites W2761128873 @default.
- W3003155131 cites W2764165143 @default.
- W3003155131 cites W2774712455 @default.
- W3003155131 cites W2792557198 @default.
- W3003155131 cites W2795686629 @default.
- W3003155131 cites W2795989238 @default.
- W3003155131 cites W2795993993 @default.
- W3003155131 cites W2796207838 @default.