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- W3003161472 abstract "Despite thousands of neuroprotectants demonstrating promise in preclinical trials, a neuroprotective therapeutic has yet to be approved for the treatment of acute brain injuries such as stroke or traumatic brain injury. Developing a more detailed understanding of models and populations demonstrating “neurological resilience” in spite of brain injury can give us important insights into new translational therapies. Resilience is the process of active adaptation to a stressor. In the context of neuroprotection, models of preconditioning and unique animal models of extreme physiology (such as hibernating species) reliably demonstrate resilience in the laboratory setting. In the clinical setting, resilience is observed in young patients and can be found in those with specific genetic polymorphisms. These important examples of resilience can help transform and extend the current neuroprotective framework from simply countering the injurious cascade into one that anticipates, monitors, and optimizes patients’ physiological responses from the time of injury throughout the process of recovery. This review summarizes the underpinnings of key adaptations common to models of resilience and how this understanding can be applied to new neuroprotective approaches." @default.
- W3003161472 created "2020-02-07" @default.
- W3003161472 creator A5020931583 @default.
- W3003161472 creator A5032223307 @default.
- W3003161472 creator A5041541324 @default.
- W3003161472 creator A5090237810 @default.
- W3003161472 date "2020-01-29" @default.
- W3003161472 modified "2023-09-27" @default.
- W3003161472 title "Resilience to Injury: A New Approach to Neuroprotection?" @default.
- W3003161472 cites W1481990397 @default.
- W3003161472 cites W1491554659 @default.
- W3003161472 cites W1505941256 @default.
- W3003161472 cites W1545082774 @default.
- W3003161472 cites W1553653089 @default.
- W3003161472 cites W1557868429 @default.
- W3003161472 cites W1568207206 @default.
- W3003161472 cites W1568910178 @default.
- W3003161472 cites W1605667856 @default.
- W3003161472 cites W1605897432 @default.
- W3003161472 cites W1627959939 @default.
- W3003161472 cites W1681621819 @default.
- W3003161472 cites W1693567495 @default.
- W3003161472 cites W1757695926 @default.
- W3003161472 cites W1809660494 @default.
- W3003161472 cites W1960815164 @default.
- W3003161472 cites W1965724936 @default.
- W3003161472 cites W1965827991 @default.
- W3003161472 cites W1967199165 @default.
- W3003161472 cites W1969770915 @default.
- W3003161472 cites W1972271649 @default.
- W3003161472 cites W1972711289 @default.
- W3003161472 cites W1973512068 @default.
- W3003161472 cites W1974898218 @default.
- W3003161472 cites W1976807374 @default.
- W3003161472 cites W1979561481 @default.
- W3003161472 cites W1979916433 @default.
- W3003161472 cites W1983216661 @default.
- W3003161472 cites W1985323628 @default.
- W3003161472 cites W1985419968 @default.
- W3003161472 cites W1985808298 @default.
- W3003161472 cites W1990210604 @default.
- W3003161472 cites W1994535293 @default.
- W3003161472 cites W2000726054 @default.
- W3003161472 cites W2000873756 @default.
- W3003161472 cites W2000965529 @default.
- W3003161472 cites W2003975764 @default.
- W3003161472 cites W2004041535 @default.
- W3003161472 cites W2005115878 @default.
- W3003161472 cites W2005829018 @default.
- W3003161472 cites W2009432050 @default.
- W3003161472 cites W2011398156 @default.
- W3003161472 cites W2013303926 @default.
- W3003161472 cites W2013391791 @default.
- W3003161472 cites W2014231458 @default.
- W3003161472 cites W2021715667 @default.
- W3003161472 cites W2024268760 @default.
- W3003161472 cites W2025150686 @default.
- W3003161472 cites W2031050265 @default.
- W3003161472 cites W2032333755 @default.
- W3003161472 cites W2037178948 @default.
- W3003161472 cites W2038322942 @default.
- W3003161472 cites W2039262033 @default.
- W3003161472 cites W2040847131 @default.
- W3003161472 cites W2042822864 @default.
- W3003161472 cites W2042933433 @default.
- W3003161472 cites W2044702738 @default.
- W3003161472 cites W2046037876 @default.
- W3003161472 cites W2049760255 @default.
- W3003161472 cites W2050235583 @default.
- W3003161472 cites W2053442326 @default.
- W3003161472 cites W205495280 @default.
- W3003161472 cites W2054987125 @default.
- W3003161472 cites W2057017838 @default.
- W3003161472 cites W2057145292 @default.
- W3003161472 cites W2058701241 @default.
- W3003161472 cites W2058880939 @default.
- W3003161472 cites W2060215608 @default.
- W3003161472 cites W2060858917 @default.
- W3003161472 cites W2063175209 @default.
- W3003161472 cites W2066908615 @default.
- W3003161472 cites W2069634387 @default.
- W3003161472 cites W2071623114 @default.
- W3003161472 cites W2073133734 @default.
- W3003161472 cites W2074270552 @default.
- W3003161472 cites W2080218239 @default.
- W3003161472 cites W2081922858 @default.
- W3003161472 cites W2083004303 @default.
- W3003161472 cites W2085799852 @default.
- W3003161472 cites W2086109332 @default.
- W3003161472 cites W2087102845 @default.
- W3003161472 cites W2089822522 @default.
- W3003161472 cites W2090431569 @default.
- W3003161472 cites W2090916792 @default.
- W3003161472 cites W2091296234 @default.
- W3003161472 cites W2094164804 @default.
- W3003161472 cites W2099572487 @default.
- W3003161472 cites W2100737789 @default.
- W3003161472 cites W2102669347 @default.