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- W3003197405 endingPage "101023" @default.
- W3003197405 startingPage "101023" @default.
- W3003197405 abstract "MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due to preanalytical and analytical challenges. This study integrated the data across twenty-four reports to identify steadily deregulated miRNAs that may assist in the path towards biomarker development and molecular characterization of the underlying pathology. Stringent KEGG pathway analysis of the miRNA targets revealed FoxO, Prolactin, TNF, and ErbB signaling pathways as the most significantly enriched categories while Gene Ontology analysis revealed that the protein targets are mostly associated with transcription. Chromosomal location of the consistently deregulated miRNAs revealed that over a third of them were clustered at the same location at Chr14q32 suggesting that they are co-regulated by specific transcription factors. This genomic region is inherently unstable due to expanded TGG repeats and responsible for human abnormalities. Stringent analysis of transcription factor sites surrounding the deregulated miRNAs revealed that CREB1, CEBPB and MAZ sites existed in approximately half of the miRNAs, including all of the miRNAs located at Chr14q32. Additional studies are now needed to determine the biomarker potential of the consistently deregulated miRNAs in PD and the therapeutic implications of these bioinformatics insights." @default.
- W3003197405 created "2020-02-07" @default.
- W3003197405 creator A5089551570 @default.
- W3003197405 date "2020-03-01" @default.
- W3003197405 modified "2023-09-26" @default.
- W3003197405 title "Cell-free microRNAs in Parkinson’s disease: potential biomarkers that provide new insights into disease pathogenesis" @default.
- W3003197405 cites W1479935944 @default.
- W3003197405 cites W1515659971 @default.
- W3003197405 cites W1533774788 @default.
- W3003197405 cites W1577577364 @default.
- W3003197405 cites W1751448311 @default.
- W3003197405 cites W1892663292 @default.
- W3003197405 cites W1967729506 @default.
- W3003197405 cites W1970994012 @default.
- W3003197405 cites W1973396607 @default.
- W3003197405 cites W1974924674 @default.
- W3003197405 cites W1977028183 @default.
- W3003197405 cites W1978337436 @default.
- W3003197405 cites W1981111142 @default.
- W3003197405 cites W1981862471 @default.
- W3003197405 cites W1982177950 @default.
- W3003197405 cites W1986579963 @default.
- W3003197405 cites W1986820918 @default.
- W3003197405 cites W1987537805 @default.
- W3003197405 cites W2000600282 @default.
- W3003197405 cites W2001176185 @default.
- W3003197405 cites W2003172650 @default.
- W3003197405 cites W2014229306 @default.
- W3003197405 cites W2015499279 @default.
- W3003197405 cites W2016801816 @default.
- W3003197405 cites W2018427433 @default.
- W3003197405 cites W2020613231 @default.
- W3003197405 cites W2021533548 @default.
- W3003197405 cites W2023973783 @default.
- W3003197405 cites W2024206172 @default.
- W3003197405 cites W2028498644 @default.
- W3003197405 cites W2028855344 @default.
- W3003197405 cites W2032313226 @default.
- W3003197405 cites W2034423511 @default.
- W3003197405 cites W2035421145 @default.
- W3003197405 cites W2036375894 @default.
- W3003197405 cites W2038874091 @default.
- W3003197405 cites W2040096338 @default.
- W3003197405 cites W2040191060 @default.
- W3003197405 cites W2041853599 @default.
- W3003197405 cites W2044780622 @default.
- W3003197405 cites W2049481764 @default.
- W3003197405 cites W2052365259 @default.
- W3003197405 cites W2053863700 @default.
- W3003197405 cites W2054278011 @default.
- W3003197405 cites W2056147363 @default.
- W3003197405 cites W2056276806 @default.
- W3003197405 cites W2058126826 @default.
- W3003197405 cites W2058964935 @default.
- W3003197405 cites W2059222949 @default.
- W3003197405 cites W2059444690 @default.
- W3003197405 cites W2060449537 @default.
- W3003197405 cites W2070296114 @default.
- W3003197405 cites W2076398196 @default.
- W3003197405 cites W2076425557 @default.
- W3003197405 cites W2086412028 @default.
- W3003197405 cites W2090440774 @default.
- W3003197405 cites W2093012444 @default.
- W3003197405 cites W2098946501 @default.
- W3003197405 cites W2099364141 @default.
- W3003197405 cites W2099824652 @default.
- W3003197405 cites W2101243397 @default.
- W3003197405 cites W2105423509 @default.
- W3003197405 cites W2112187582 @default.
- W3003197405 cites W2112455323 @default.
- W3003197405 cites W2112543725 @default.
- W3003197405 cites W2115093090 @default.
- W3003197405 cites W2118614725 @default.
- W3003197405 cites W2128690808 @default.
- W3003197405 cites W2130979840 @default.
- W3003197405 cites W2131844320 @default.
- W3003197405 cites W2133258287 @default.
- W3003197405 cites W2136229065 @default.
- W3003197405 cites W2137085566 @default.
- W3003197405 cites W2137110561 @default.
- W3003197405 cites W2137669678 @default.
- W3003197405 cites W2137814024 @default.
- W3003197405 cites W2137829901 @default.
- W3003197405 cites W2138198318 @default.
- W3003197405 cites W2139296565 @default.
- W3003197405 cites W2140124258 @default.
- W3003197405 cites W2142940765 @default.
- W3003197405 cites W2144339761 @default.
- W3003197405 cites W2145050029 @default.
- W3003197405 cites W2150543872 @default.
- W3003197405 cites W2157793936 @default.
- W3003197405 cites W2158217645 @default.
- W3003197405 cites W2159627472 @default.
- W3003197405 cites W2164116473 @default.
- W3003197405 cites W2164706138 @default.
- W3003197405 cites W2167976457 @default.
- W3003197405 cites W2188632302 @default.
- W3003197405 cites W2197013324 @default.