Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003204656> ?p ?o ?g. }
- W3003204656 endingPage "70" @default.
- W3003204656 startingPage "61" @default.
- W3003204656 abstract "The master transcriptional regulator MYB is a key oncogenic driver in several human neoplasms, particularly in acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). MYB is therefore an attractive target for drug development in MYB-activated malignancies. Here, we employed a MYB-reporter cell line and identified the polyether ionophores monensin, salinomycin, and nigericin as novel inhibitors of MYB activity. As a proof of principle, we show that monensin affects the expression of a significant number of MYB-regulated genes in AML cells and causes down-regulation of MYB expression, loss of cell viability, and induction of differentiation and apoptosis. Furthermore, monensin significantly inhibits proliferation of primary murine AML cells but not of normal hematopoietic progenitors, reflecting a high MYB-dependence of leukemic cells and underscoring the efficacy of monensin in MYB-activated malignancies. Importantly, monensin also suppressed the viability and non-adherent growth of adenoid cystic carcinoma (ACC) cells expressing MYB-NFIB fusion oncoproteins. Our data show that a single compound with significant MYB-inhibitory activity is effective against malignant cells from two distinct MYB-driven human neoplasms. Hence, monensin and related compounds are promising molecular scaffolds for development of novel MYB inhibitors." @default.
- W3003204656 created "2020-02-07" @default.
- W3003204656 creator A5000412848 @default.
- W3003204656 creator A5003684650 @default.
- W3003204656 creator A5009885367 @default.
- W3003204656 creator A5036792762 @default.
- W3003204656 creator A5037115554 @default.
- W3003204656 creator A5039339059 @default.
- W3003204656 creator A5046218921 @default.
- W3003204656 creator A5058122841 @default.
- W3003204656 creator A5075104061 @default.
- W3003204656 creator A5076395822 @default.
- W3003204656 date "2020-06-01" @default.
- W3003204656 modified "2023-09-29" @default.
- W3003204656 title "Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells" @default.
- W3003204656 cites W1970309962 @default.
- W3003204656 cites W1971265845 @default.
- W3003204656 cites W1974202442 @default.
- W3003204656 cites W1980039397 @default.
- W3003204656 cites W1988311706 @default.
- W3003204656 cites W1992150326 @default.
- W3003204656 cites W1997183854 @default.
- W3003204656 cites W2010618201 @default.
- W3003204656 cites W2023014537 @default.
- W3003204656 cites W2025735188 @default.
- W3003204656 cites W2027935587 @default.
- W3003204656 cites W2035346960 @default.
- W3003204656 cites W2050292404 @default.
- W3003204656 cites W2050963209 @default.
- W3003204656 cites W2052027210 @default.
- W3003204656 cites W2061308322 @default.
- W3003204656 cites W2063893501 @default.
- W3003204656 cites W2066737158 @default.
- W3003204656 cites W2072299887 @default.
- W3003204656 cites W2082414039 @default.
- W3003204656 cites W2084818621 @default.
- W3003204656 cites W2107031305 @default.
- W3003204656 cites W2112487172 @default.
- W3003204656 cites W2114160655 @default.
- W3003204656 cites W2120656656 @default.
- W3003204656 cites W2121260047 @default.
- W3003204656 cites W2122321442 @default.
- W3003204656 cites W2122958542 @default.
- W3003204656 cites W2123719503 @default.
- W3003204656 cites W2128246136 @default.
- W3003204656 cites W2134830435 @default.
- W3003204656 cites W2145665617 @default.
- W3003204656 cites W2147347701 @default.
- W3003204656 cites W2154243294 @default.
- W3003204656 cites W2155635108 @default.
- W3003204656 cites W2162279004 @default.
- W3003204656 cites W2170251269 @default.
- W3003204656 cites W2172993862 @default.
- W3003204656 cites W2187302027 @default.
- W3003204656 cites W2268032794 @default.
- W3003204656 cites W2283434330 @default.
- W3003204656 cites W2313609969 @default.
- W3003204656 cites W2323189975 @default.
- W3003204656 cites W2529239871 @default.
- W3003204656 cites W2541333138 @default.
- W3003204656 cites W2561795595 @default.
- W3003204656 cites W2593437745 @default.
- W3003204656 cites W2614441145 @default.
- W3003204656 cites W2620374753 @default.
- W3003204656 cites W2766219330 @default.
- W3003204656 cites W2781859730 @default.
- W3003204656 cites W2889286273 @default.
- W3003204656 cites W2890007148 @default.
- W3003204656 cites W2903729963 @default.
- W3003204656 cites W2944636426 @default.
- W3003204656 cites W839585666 @default.
- W3003204656 doi "https://doi.org/10.1016/j.canlet.2020.01.039" @default.
- W3003204656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32014461" @default.
- W3003204656 hasPublicationYear "2020" @default.
- W3003204656 type Work @default.
- W3003204656 sameAs 3003204656 @default.
- W3003204656 citedByCount "38" @default.
- W3003204656 countsByYear W30032046562020 @default.
- W3003204656 countsByYear W30032046562021 @default.
- W3003204656 countsByYear W30032046562022 @default.
- W3003204656 countsByYear W30032046562023 @default.
- W3003204656 crossrefType "journal-article" @default.
- W3003204656 hasAuthorship W3003204656A5000412848 @default.
- W3003204656 hasAuthorship W3003204656A5003684650 @default.
- W3003204656 hasAuthorship W3003204656A5009885367 @default.
- W3003204656 hasAuthorship W3003204656A5036792762 @default.
- W3003204656 hasAuthorship W3003204656A5037115554 @default.
- W3003204656 hasAuthorship W3003204656A5039339059 @default.
- W3003204656 hasAuthorship W3003204656A5046218921 @default.
- W3003204656 hasAuthorship W3003204656A5058122841 @default.
- W3003204656 hasAuthorship W3003204656A5075104061 @default.
- W3003204656 hasAuthorship W3003204656A5076395822 @default.
- W3003204656 hasConcept C104317684 @default.
- W3003204656 hasConcept C126322002 @default.
- W3003204656 hasConcept C140793950 @default.
- W3003204656 hasConcept C150194340 @default.
- W3003204656 hasConcept C2777546739 @default.
- W3003204656 hasConcept C2778461978 @default.