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- W3003221014 endingPage "2374" @default.
- W3003221014 startingPage "2370" @default.
- W3003221014 abstract "Abstract The preparation of acyclic β‐fluoro amines bearing tetrasubstituted fluorine stereocenters is described via a direct Zn/ProPhenol‐catalyzed Mannich reaction. The reaction utilizes branched vinyl or alkynyl α‐fluoro ketones that can be coupled with a range of aryl, heteroaryl, vinyl, or cyclopropyl aldimines in high yield and with excellent diastereo‐ (up to >20:1) and enantioselectivity (up to 99 %). The use of readily cleaved tert ‐butoxycarbonyl (Boc) or carboxybenzyl (Cbz) imine protecting groups adds utility to the reaction by allowing for easy access to the free amine products under mild and chemoselective reaction conditions." @default.
- W3003221014 created "2020-02-07" @default.
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- W3003221014 date "2020-01-03" @default.
- W3003221014 modified "2023-09-25" @default.
- W3003221014 title "Acyclic Branched α‐Fluoro Ketones for the Direct Asymmetric Mannich Reaction Leading to the Synthesis of β‐Tetrasubstituted β‐Fluoro Amines" @default.
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- W3003221014 doi "https://doi.org/10.1002/anie.201913927" @default.
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