Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003236708> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3003236708 endingPage "S153" @default.
- W3003236708 startingPage "S152" @default.
- W3003236708 abstract "Clinical manifestations of envenomings by bites of the viperid snakes Bothrops asper and Daboia russelii show marked differences. Both venoms elicit the typical effects induced by viperid venoms (local tissue damage, bleeding, coagulopathies, shock). In addition, envenomings by D. russelii are characterized by a high incidence of acute kidney injury and by systemic capillary leak syndrome. The present investigation aimed to compare the local pathological and inflammatory events induced by the intramuscular injection of these venoms in a mouse model. B. asper venom induced stronger local hemorrhage, whereas D. russelii venom caused a higher extent of myonecrosis, and both venoms induced inflammation. Exudates collected from the site of tissue damage showed higher proteolytic activity in the case of samples from B. asper venom-treated mice. This activity was abrogated by antivenoms, indicating that it is the result of the action of venom proteinases. In addition, an increase in matrix metalloproteinases (MMPs) over time was detected in exudates induced by both venoms. Proteome analysis of exudates revealed higher abundance of extracellular matrix (ECM)-derived protein fragments in samples collected from B. asper venom-injected mice, whereas those from D. russelii venom-injected animals had higher amounts of intracellular proteins. Analysis of the subproteome of inflammatory mediators in exudates showed various patterns of change over time. Some mediators peaked at 180 min and decreased afterwards, whereas others increased and remained elevated during the 360 min observation period. Interestingly, various mediators (MIP-1α, MIP-1β, KC, MIP-2, GM-CSF, VEGF, and LIX) increased and then decreased in the case of B. asper venom, while they remained elevated at 360 min in the case of D. russelii venom. Our findings show that these venoms induce a different pattern of local tissue damage and suggest that the venom of D. russelii induces a more sustained inflammatory reaction, an observation that may have implications for the pathophysiology of envenomings." @default.
- W3003236708 created "2020-02-07" @default.
- W3003236708 creator A5001000588 @default.
- W3003236708 creator A5005659288 @default.
- W3003236708 creator A5006290729 @default.
- W3003236708 creator A5010336803 @default.
- W3003236708 creator A5013164995 @default.
- W3003236708 creator A5013305743 @default.
- W3003236708 creator A5013934243 @default.
- W3003236708 creator A5015491673 @default.
- W3003236708 creator A5018411206 @default.
- W3003236708 creator A5024673974 @default.
- W3003236708 creator A5025839352 @default.
- W3003236708 creator A5032902650 @default.
- W3003236708 creator A5033198555 @default.
- W3003236708 creator A5039705405 @default.
- W3003236708 creator A5058714848 @default.
- W3003236708 creator A5069355727 @default.
- W3003236708 creator A5080600115 @default.
- W3003236708 creator A5081937825 @default.
- W3003236708 date "2020-02-01" @default.
- W3003236708 modified "2023-10-14" @default.
- W3003236708 title "Long-acting glyco-design (LAGD) for improved kinetics and distribution of α-galactosidase A" @default.
- W3003236708 doi "https://doi.org/10.1016/j.ymgme.2019.11.404" @default.
- W3003236708 hasPublicationYear "2020" @default.
- W3003236708 type Work @default.
- W3003236708 sameAs 3003236708 @default.
- W3003236708 citedByCount "0" @default.
- W3003236708 crossrefType "journal-article" @default.
- W3003236708 hasAuthorship W3003236708A5001000588 @default.
- W3003236708 hasAuthorship W3003236708A5005659288 @default.
- W3003236708 hasAuthorship W3003236708A5006290729 @default.
- W3003236708 hasAuthorship W3003236708A5010336803 @default.
- W3003236708 hasAuthorship W3003236708A5013164995 @default.
- W3003236708 hasAuthorship W3003236708A5013305743 @default.
- W3003236708 hasAuthorship W3003236708A5013934243 @default.
- W3003236708 hasAuthorship W3003236708A5015491673 @default.
- W3003236708 hasAuthorship W3003236708A5018411206 @default.
- W3003236708 hasAuthorship W3003236708A5024673974 @default.
- W3003236708 hasAuthorship W3003236708A5025839352 @default.
- W3003236708 hasAuthorship W3003236708A5032902650 @default.
- W3003236708 hasAuthorship W3003236708A5033198555 @default.
- W3003236708 hasAuthorship W3003236708A5039705405 @default.
- W3003236708 hasAuthorship W3003236708A5058714848 @default.
- W3003236708 hasAuthorship W3003236708A5069355727 @default.
- W3003236708 hasAuthorship W3003236708A5080600115 @default.
- W3003236708 hasAuthorship W3003236708A5081937825 @default.
- W3003236708 hasConcept C109523444 @default.
- W3003236708 hasConcept C203014093 @default.
- W3003236708 hasConcept C2776725428 @default.
- W3003236708 hasConcept C2776914184 @default.
- W3003236708 hasConcept C2779448229 @default.
- W3003236708 hasConcept C2779815518 @default.
- W3003236708 hasConcept C55493867 @default.
- W3003236708 hasConcept C86803240 @default.
- W3003236708 hasConcept C98274493 @default.
- W3003236708 hasConceptScore W3003236708C109523444 @default.
- W3003236708 hasConceptScore W3003236708C203014093 @default.
- W3003236708 hasConceptScore W3003236708C2776725428 @default.
- W3003236708 hasConceptScore W3003236708C2776914184 @default.
- W3003236708 hasConceptScore W3003236708C2779448229 @default.
- W3003236708 hasConceptScore W3003236708C2779815518 @default.
- W3003236708 hasConceptScore W3003236708C55493867 @default.
- W3003236708 hasConceptScore W3003236708C86803240 @default.
- W3003236708 hasConceptScore W3003236708C98274493 @default.
- W3003236708 hasIssue "2" @default.
- W3003236708 hasLocation W30032367081 @default.
- W3003236708 hasOpenAccess W3003236708 @default.
- W3003236708 hasPrimaryLocation W30032367081 @default.
- W3003236708 hasRelatedWork W1991690347 @default.
- W3003236708 hasRelatedWork W2036693266 @default.
- W3003236708 hasRelatedWork W2079720332 @default.
- W3003236708 hasRelatedWork W2091861607 @default.
- W3003236708 hasRelatedWork W2134248292 @default.
- W3003236708 hasRelatedWork W2153832816 @default.
- W3003236708 hasRelatedWork W2591900435 @default.
- W3003236708 hasRelatedWork W2998313399 @default.
- W3003236708 hasRelatedWork W3038120307 @default.
- W3003236708 hasRelatedWork W4205257317 @default.
- W3003236708 hasVolume "129" @default.
- W3003236708 isParatext "false" @default.
- W3003236708 isRetracted "false" @default.
- W3003236708 magId "3003236708" @default.
- W3003236708 workType "article" @default.