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- W3003245890 endingPage "338" @default.
- W3003245890 startingPage "338" @default.
- W3003245890 abstract "Acute kidney injury (AKI) is a major kidney disease characterized by rapid decline of renal function. Besides its acute consequence of high mortality, AKI has recently been recognized as an independent risk factor for chronic kidney disease (CKD). Maladaptive or incomplete repair of renal tubules after severe or episodic AKI leads to renal fibrosis and, eventually, CKD. Recent studies highlight a key role of mitochondrial pathology in AKI development and abnormal kidney repair after AKI. As such, timely elimination of damaged mitochondria in renal tubular cells represents an important quality control mechanism for cell homeostasis and survival during kidney injury and repair. Mitophagy is a selective form of autophagy that selectively removes redundant or damaged mitochondria. Here, we summarize our recent understanding on the molecular mechanisms of mitophagy, discuss the role of mitophagy in AKI development and kidney repair after AKI, and present future research directions and therapeutic potential." @default.
- W3003245890 created "2020-02-07" @default.
- W3003245890 creator A5018863416 @default.
- W3003245890 creator A5050155862 @default.
- W3003245890 creator A5063731595 @default.
- W3003245890 creator A5083220383 @default.
- W3003245890 date "2020-02-01" @default.
- W3003245890 modified "2023-10-16" @default.
- W3003245890 title "Mitophagy in Acute Kidney Injury and Kidney Repair" @default.
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