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• W3003256221 abstract "Homeostasis of Drosophila germline stem cells (GSC) depends upon the integration of intrinsic and extrinsic signals. This review highlights emerging data that support nuclear architecture as an intrinsic regulator of GSC maintenance and germ cell differentiation. Here, we focus on the nuclear lamina (NL) and the nucleolus, two compartments that undergo alterations in composition upon germ cell differentiation. Loss of NL or nucleolar components leads to GSC loss, resulting from activation of GSC quality control checkpoint pathways. We suggest that the NL and nucleolus integrate signals needed for the switch between GSC maintenance and germ cell differentiation, and propose regulation of nuclear actin pools as one mechanism that connects these compartments." @default.
• W3003256221 created "2020-02-07" @default.
• W3003256221 creator A5017028389 @default.
• W3003256221 creator A5031373110 @default.
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• W3003256221 creator A5072858487 @default.
• W3003256221 date "2020-02-01" @default.
• W3003256221 modified "2023-10-10" @default.
• W3003256221 title "Nuclear architecture as an intrinsic regulator of Drosophila female germline stem cell maintenance" @default.
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• W3003256221 doi "https://doi.org/10.1016/j.cois.2019.11.007" @default.
• W3003256221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7089816" @default.
• W3003256221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32087561" @default.
• W3003256221 hasPublicationYear "2020" @default.
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