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- W3003258587 endingPage "42" @default.
- W3003258587 startingPage "34" @default.
- W3003258587 abstract "Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and response to antigen; however, autophagy in immune cells may be beneficial or detrimental depending on the developmental stage of the cell and more specifically its degree of differentiation. Autophagy-deficient hosts present variations in many metabolites, proteins and enzymes that may have tumor-promoting or -inhibiting effects. The centrality of autophagy in the metabolism of some cancers and immune cells poses as a critical target whose mechanisms must be further unraveled to optimize patient response and prevent tumor recurrence." @default.
- W3003258587 created "2020-02-07" @default.
- W3003258587 creator A5005509338 @default.
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- W3003258587 creator A5016341240 @default.
- W3003258587 creator A5019825145 @default.
- W3003258587 creator A5033595397 @default.
- W3003258587 date "2020-04-01" @default.
- W3003258587 modified "2023-10-18" @default.
- W3003258587 title "Autophagy regulation as a promising approach for improving cancer immunotherapy" @default.
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