Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003258772> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3003258772 endingPage "108971" @default.
- W3003258772 startingPage "108971" @default.
- W3003258772 abstract "Pulpal infection is one of the most common causes of dental emergency admission. Tooth pain due to infection caused by gram-negative bacteria is the main manifestation of this sort of dental problem. The GPR173 signaling pathway is a highly conserved G-protein-coupled receptor that mediates neurological and reproductive function. In this study, we found that GPR173 was fairly expressed in isolated human dental pulp cells, and its expression was reduced in response to pro-inflammatory lipopolysaccharide (LPS) treatment. The activation of GPR173 by its ligand Phoenixin-20 reduced LPS-induced cytotoxicity, as revealed by a reduction in the release of LDH. Additionally, Phoenixin-20 suppressed LPS-induced release of pro-inflammatory cytokines and inflammatory mediators, including IL-6, MCP-1, VCAM-1, and ICAM-1, as well as MMP-2 and MMP-9. Mechanistically, we showed the suppressive action of Phoenixin-20 on LPS-induced activation of TLR-4 and Myd88 as well as the activation of the NF-κB pathway. Collectively, our study demonstrates that the GPR173 signaling pathway is an important mediator of LPS-induced inflammation, and the activation of GPR173 by its natural ligand Phoenixin-20 exhibits robust anti-inflammatory effects in dental pulp cells, suggesting that GPR173 is an interesting target molecule in the development of pulp cell-based therapies." @default.
- W3003258772 created "2020-02-07" @default.
- W3003258772 creator A5017258526 @default.
- W3003258772 creator A5021541475 @default.
- W3003258772 creator A5042272751 @default.
- W3003258772 creator A5065853781 @default.
- W3003258772 date "2020-02-01" @default.
- W3003258772 modified "2023-09-28" @default.
- W3003258772 title "Phoenixin-20 suppresses lipopolysaccharide-induced inflammation in dental pulp cells" @default.
- W3003258772 cites W1011147171 @default.
- W3003258772 cites W1986711353 @default.
- W3003258772 cites W1986752194 @default.
- W3003258772 cites W2013322085 @default.
- W3003258772 cites W2016155187 @default.
- W3003258772 cites W2018319583 @default.
- W3003258772 cites W2023447919 @default.
- W3003258772 cites W2028817918 @default.
- W3003258772 cites W2052719609 @default.
- W3003258772 cites W2055958188 @default.
- W3003258772 cites W2088931183 @default.
- W3003258772 cites W2135050229 @default.
- W3003258772 cites W2146056177 @default.
- W3003258772 cites W2213691097 @default.
- W3003258772 cites W2337673903 @default.
- W3003258772 cites W2558246933 @default.
- W3003258772 cites W2590225953 @default.
- W3003258772 cites W2747242946 @default.
- W3003258772 cites W2767343845 @default.
- W3003258772 cites W2790359783 @default.
- W3003258772 cites W2791920195 @default.
- W3003258772 cites W2800919048 @default.
- W3003258772 cites W2809568031 @default.
- W3003258772 cites W2926744003 @default.
- W3003258772 cites W2952069462 @default.
- W3003258772 cites W4234095729 @default.
- W3003258772 doi "https://doi.org/10.1016/j.cbi.2020.108971" @default.
- W3003258772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32017913" @default.
- W3003258772 hasPublicationYear "2020" @default.
- W3003258772 type Work @default.
- W3003258772 sameAs 3003258772 @default.
- W3003258772 citedByCount "21" @default.
- W3003258772 countsByYear W30032587722020 @default.
- W3003258772 countsByYear W30032587722021 @default.
- W3003258772 countsByYear W30032587722022 @default.
- W3003258772 countsByYear W30032587722023 @default.
- W3003258772 crossrefType "journal-article" @default.
- W3003258772 hasAuthorship W3003258772A5017258526 @default.
- W3003258772 hasAuthorship W3003258772A5021541475 @default.
- W3003258772 hasAuthorship W3003258772A5042272751 @default.
- W3003258772 hasAuthorship W3003258772A5065853781 @default.
- W3003258772 hasConcept C164027704 @default.
- W3003258772 hasConcept C170493617 @default.
- W3003258772 hasConcept C17991360 @default.
- W3003258772 hasConcept C185592680 @default.
- W3003258772 hasConcept C203014093 @default.
- W3003258772 hasConcept C2107291 @default.
- W3003258772 hasConcept C2776070231 @default.
- W3003258772 hasConcept C2776914184 @default.
- W3003258772 hasConcept C2778754761 @default.
- W3003258772 hasConcept C55493867 @default.
- W3003258772 hasConcept C62478195 @default.
- W3003258772 hasConcept C71924100 @default.
- W3003258772 hasConcept C86803240 @default.
- W3003258772 hasConcept C95444343 @default.
- W3003258772 hasConceptScore W3003258772C164027704 @default.
- W3003258772 hasConceptScore W3003258772C170493617 @default.
- W3003258772 hasConceptScore W3003258772C17991360 @default.
- W3003258772 hasConceptScore W3003258772C185592680 @default.
- W3003258772 hasConceptScore W3003258772C203014093 @default.
- W3003258772 hasConceptScore W3003258772C2107291 @default.
- W3003258772 hasConceptScore W3003258772C2776070231 @default.
- W3003258772 hasConceptScore W3003258772C2776914184 @default.
- W3003258772 hasConceptScore W3003258772C2778754761 @default.
- W3003258772 hasConceptScore W3003258772C55493867 @default.
- W3003258772 hasConceptScore W3003258772C62478195 @default.
- W3003258772 hasConceptScore W3003258772C71924100 @default.
- W3003258772 hasConceptScore W3003258772C86803240 @default.
- W3003258772 hasConceptScore W3003258772C95444343 @default.
- W3003258772 hasLocation W30032587721 @default.
- W3003258772 hasLocation W30032587722 @default.
- W3003258772 hasOpenAccess W3003258772 @default.
- W3003258772 hasPrimaryLocation W30032587721 @default.
- W3003258772 hasRelatedWork W1558781074 @default.
- W3003258772 hasRelatedWork W1989925225 @default.
- W3003258772 hasRelatedWork W1994284968 @default.
- W3003258772 hasRelatedWork W2038980388 @default.
- W3003258772 hasRelatedWork W2063111353 @default.
- W3003258772 hasRelatedWork W2371609395 @default.
- W3003258772 hasRelatedWork W2372867219 @default.
- W3003258772 hasRelatedWork W2403366498 @default.
- W3003258772 hasRelatedWork W4224862991 @default.
- W3003258772 hasRelatedWork W4311969349 @default.
- W3003258772 hasVolume "318" @default.
- W3003258772 isParatext "false" @default.
- W3003258772 isRetracted "false" @default.
- W3003258772 magId "3003258772" @default.
- W3003258772 workType "article" @default.