FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003288134> ?p ?o ?g. }

• W3003288134 endingPage "2020" @default.
• W3003288134 startingPage "2000" @default.
• W3003288134 abstract "Injured retinas in mammals do not regenerate and heal with loss of function. The adult retina of zebrafish self-repairs after damage by activating cell-intrinsic mechanisms, which are regulated by extrinsic signal interactions. Among relevant regulatory extrinsic systems, purinergic signaling regulates progenitor proliferation during retinogenesis and regeneration and glia proliferation in proliferative retinopathies. ATP-activated P2X7 (P2RX7) and adenosine (P1R) receptors are involved in the progression of almost all retinopathies leading to blindness. Here, we examined P2RX7 and P1R participation in the retina regenerative response induced by photoreceptor damage caused by a specific dose of CoCl2 . First, we found that treatment of uninjured retinas with a potent agonist of P2RX7 (BzATP) provoked photoreceptor damage and mitotic activation of multipotent progenitors. In CoCl2 -injured retinas, blockade of endogenous extracellular ATP activity on P2RX7 caused further neurodegeneration, Müller cell gliosis, progenitor proliferation, and microglia reactivity. P2RX7 inhibition in injured retinas also increased the expression of lin28a and tnfα genes, which are related to multipotent progenitor proliferation. Levels of hif1α, vegf3r, and vegfaa mRNA were enhanced by blockade of P2RX7 immediately after injury, indicating hypoxic like damage and endothelial cell growth and proliferation. Complete depletion of extracellular nucleotides with an apyrase treatment strongly potentiated cell death and progenitor proliferation induced with CoCl2 . Blockade of adenosine P1 and A2A receptors (A2A R) had deleterious effects and deregulated normal timing for progenitor and precursor cell proliferation following photoreceptor damage. ATP via P2RX7 and adenosine via A2A R are survival extracellular signals key for retina regeneration in zebrafish." @default.
• W3003288134 created "2020-02-07" @default.
• W3003288134 creator A5011967751 @default.
• W3003288134 creator A5037181066 @default.
• W3003288134 creator A5060778204 @default.
• W3003288134 creator A5066001231 @default.
• W3003288134 date "2020-02-07" @default.
• W3003288134 modified "2023-10-06" @default.
• W3003288134 title "P2X7 and A _2A receptor endogenous activation protects against neuronal death caused by CoCl ₂ ‐induced photoreceptor toxicity in the zebrafish retina" @default.
• W3003288134 cites W1482556877 @default.
• W3003288134 cites W1497974870 @default.
• W3003288134 cites W1603862527 @default.
• W3003288134 cites W1964826587 @default.
• W3003288134 cites W1965128300 @default.
• W3003288134 cites W1970158133 @default.
• W3003288134 cites W1974742102 @default.
• W3003288134 cites W1975520024 @default.
• W3003288134 cites W1976734103 @default.
• W3003288134 cites W1979509436 @default.
• W3003288134 cites W1980111715 @default.
• W3003288134 cites W1981536211 @default.
• W3003288134 cites W1981845210 @default.
• W3003288134 cites W1986001824 @default.
• W3003288134 cites W1992663358 @default.
• W3003288134 cites W1998962476 @default.
• W3003288134 cites W1998998050 @default.
• W3003288134 cites W2004380591 @default.
• W3003288134 cites W2007426180 @default.
• W3003288134 cites W2009419319 @default.
• W3003288134 cites W2012835937 @default.
• W3003288134 cites W2014721583 @default.
• W3003288134 cites W2021451835 @default.
• W3003288134 cites W2021547248 @default.
• W3003288134 cites W2022545583 @default.
• W3003288134 cites W2023830878 @default.
• W3003288134 cites W2026819066 @default.
• W3003288134 cites W2030827604 @default.
• W3003288134 cites W2034837063 @default.
• W3003288134 cites W2038162343 @default.
• W3003288134 cites W2043116574 @default.
• W3003288134 cites W2045540976 @default.
• W3003288134 cites W2046695127 @default.
• W3003288134 cites W2052672198 @default.
• W3003288134 cites W2054724063 @default.
• W3003288134 cites W2060955755 @default.
• W3003288134 cites W2061932756 @default.
• W3003288134 cites W2065072199 @default.
• W3003288134 cites W2066784771 @default.
• W3003288134 cites W2068442916 @default.
• W3003288134 cites W2070208201 @default.
• W3003288134 cites W2070809056 @default.
• W3003288134 cites W2072170174 @default.
• W3003288134 cites W2085375111 @default.
• W3003288134 cites W2085569558 @default.
• W3003288134 cites W2089043139 @default.
• W3003288134 cites W2090022723 @default.
• W3003288134 cites W2099636023 @default.
• W3003288134 cites W2102530042 @default.
• W3003288134 cites W2104008103 @default.
• W3003288134 cites W2109074671 @default.
• W3003288134 cites W2112839409 @default.
• W3003288134 cites W2133942268 @default.
• W3003288134 cites W2134766534 @default.
• W3003288134 cites W2146908013 @default.
• W3003288134 cites W2154229359 @default.
• W3003288134 cites W2156667412 @default.
• W3003288134 cites W2168634451 @default.
• W3003288134 cites W2173910108 @default.
• W3003288134 cites W2193158796 @default.
• W3003288134 cites W2317327088 @default.
• W3003288134 cites W2339829205 @default.
• W3003288134 cites W236931999 @default.
• W3003288134 cites W2472172082 @default.
• W3003288134 cites W2515146356 @default.
• W3003288134 cites W2530778444 @default.
• W3003288134 cites W2555164289 @default.
• W3003288134 cites W2571141755 @default.
• W3003288134 cites W2572643638 @default.
• W3003288134 cites W2577295301 @default.
• W3003288134 cites W2581020313 @default.
• W3003288134 cites W2592772318 @default.
• W3003288134 cites W2621392352 @default.
• W3003288134 cites W2734794092 @default.
• W3003288134 cites W2755476069 @default.
• W3003288134 cites W2763113126 @default.
• W3003288134 cites W2791920202 @default.
• W3003288134 cites W2793479725 @default.
• W3003288134 cites W2793997400 @default.
• W3003288134 cites W2885176008 @default.
• W3003288134 cites W2900485438 @default.
• W3003288134 cites W4241134185 @default.
• W3003288134 cites W71725349 @default.
• W3003288134 doi "https://doi.org/10.1002/cne.24869" @default.
• W3003288134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31997350" @default.
• W3003288134 hasPublicationYear "2020" @default.
• W3003288134 type Work @default.
• W3003288134 sameAs 3003288134 @default.
• W3003288134 citedByCount "6" @default.

• next