Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003293145> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3003293145 abstract "Abstract Motivation Big data era in genomics promises a breakthrough in medicine, but sharing data in a private manner limits the pace of field. Widely accepted “genomic data-sharing beacon” protocol provides a standardized and secure interface for querying the genomic datasets. The data is only shared if the desired information (e.g., a certain variant) exists in the dataset. Various studies showed that beacons are vulnerable to re-identification (or membership inference) attacks. As beacons are generally associated with sensitive phenotype information, re-identification creates a significant risk for the participants. Unfortunately, proposed countermeasures against such attacks have failed to be effective, as they do not consider the utility of beacon protocol. Results In this study, for the first time, we analyze the mitigation effect of the kinship relationships among beacon participants against re-identification attacks. We argue that having multiple family members in a beacon can garble the information for attacks since a substantial number of variants are shared among kinrelated people. Using family genomes from HapMap and synthetically-generated datasets, we show that having one of the parents of a victim in the beacon causes (i) significant decrease in the power of attacks and (ii) substantial increase in the number of queries needed to confirm an individual’s beacon membership. We also show how the protection effect attenuates when more distant relatives, such as grandparents are included alongside the victim. Furthermore, we quantify the utility loss due adding relatives and show that it is smaller compared to flipping based techniques." @default.
- W3003293145 created "2020-02-07" @default.
- W3003293145 creator A5028326739 @default.
- W3003293145 creator A5061995903 @default.
- W3003293145 creator A5076400344 @default.
- W3003293145 creator A5090836372 @default.
- W3003293145 date "2020-01-31" @default.
- W3003293145 modified "2023-09-26" @default.
- W3003293145 title "The Effect of Kinship in Re-identification Attacks Against Genomic Data Sharing Beacons" @default.
- W3003293145 cites W1838635991 @default.
- W3003293145 cites W2002458933 @default.
- W3003293145 cites W2038416582 @default.
- W3003293145 cites W2058401000 @default.
- W3003293145 cites W2217809488 @default.
- W3003293145 cites W2573423285 @default.
- W3003293145 cites W2609272369 @default.
- W3003293145 cites W2618028147 @default.
- W3003293145 cites W2888657901 @default.
- W3003293145 cites W2919288702 @default.
- W3003293145 doi "https://doi.org/10.1101/2020.01.30.926907" @default.
- W3003293145 hasPublicationYear "2020" @default.
- W3003293145 type Work @default.
- W3003293145 sameAs 3003293145 @default.
- W3003293145 citedByCount "0" @default.
- W3003293145 crossrefType "posted-content" @default.
- W3003293145 hasAuthorship W3003293145A5028326739 @default.
- W3003293145 hasAuthorship W3003293145A5061995903 @default.
- W3003293145 hasAuthorship W3003293145A5076400344 @default.
- W3003293145 hasAuthorship W3003293145A5090836372 @default.
- W3003293145 hasBestOaLocation W30032931451 @default.
- W3003293145 hasConcept C102168758 @default.
- W3003293145 hasConcept C108827166 @default.
- W3003293145 hasConcept C116834253 @default.
- W3003293145 hasConcept C142724271 @default.
- W3003293145 hasConcept C144348335 @default.
- W3003293145 hasConcept C17744445 @default.
- W3003293145 hasConcept C199539241 @default.
- W3003293145 hasConcept C204787440 @default.
- W3003293145 hasConcept C2780385302 @default.
- W3003293145 hasConcept C31258907 @default.
- W3003293145 hasConcept C38652104 @default.
- W3003293145 hasConcept C41008148 @default.
- W3003293145 hasConcept C59822182 @default.
- W3003293145 hasConcept C71924100 @default.
- W3003293145 hasConcept C86803240 @default.
- W3003293145 hasConceptScore W3003293145C102168758 @default.
- W3003293145 hasConceptScore W3003293145C108827166 @default.
- W3003293145 hasConceptScore W3003293145C116834253 @default.
- W3003293145 hasConceptScore W3003293145C142724271 @default.
- W3003293145 hasConceptScore W3003293145C144348335 @default.
- W3003293145 hasConceptScore W3003293145C17744445 @default.
- W3003293145 hasConceptScore W3003293145C199539241 @default.
- W3003293145 hasConceptScore W3003293145C204787440 @default.
- W3003293145 hasConceptScore W3003293145C2780385302 @default.
- W3003293145 hasConceptScore W3003293145C31258907 @default.
- W3003293145 hasConceptScore W3003293145C38652104 @default.
- W3003293145 hasConceptScore W3003293145C41008148 @default.
- W3003293145 hasConceptScore W3003293145C59822182 @default.
- W3003293145 hasConceptScore W3003293145C71924100 @default.
- W3003293145 hasConceptScore W3003293145C86803240 @default.
- W3003293145 hasLocation W30032931451 @default.
- W3003293145 hasLocation W30032931452 @default.
- W3003293145 hasOpenAccess W3003293145 @default.
- W3003293145 hasPrimaryLocation W30032931451 @default.
- W3003293145 hasRelatedWork W10100871 @default.
- W3003293145 hasRelatedWork W10340342 @default.
- W3003293145 hasRelatedWork W14663730 @default.
- W3003293145 hasRelatedWork W1681560 @default.
- W3003293145 hasRelatedWork W2183821 @default.
- W3003293145 hasRelatedWork W5291490 @default.
- W3003293145 hasRelatedWork W58061 @default.
- W3003293145 hasRelatedWork W6745555 @default.
- W3003293145 hasRelatedWork W7753088 @default.
- W3003293145 hasRelatedWork W8048581 @default.
- W3003293145 isParatext "false" @default.
- W3003293145 isRetracted "false" @default.
- W3003293145 magId "3003293145" @default.
- W3003293145 workType "article" @default.