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- W3003297751 abstract "Despite the widespread use of nanomaterials in various areas of industry and medicine, the question of assessing their safety, in particular, genotoxicity, remains to be open. The review presents the analysis of the results of a number of nanomaterials mutagenic activity evaluations in the test for induction of reverse mutations in bacteria (the Ames test). The literature search was carried out using PubMed, eLIBRARY.RU, Web of Science, Google Scholar databases up to 2019. The analysis of the literature showed mostly negative results on the induction of gene mutations. Particularly, quantum dots (QD), nanoparticles, and nanofibres of aluminum oxide and hydroxide, multi-walled carbon nanotubes (MWCNTs) and single-wall carbon nanotubes (SWCNTs) did not induce gene mutations. Among the more than 120 different types of nanomaterials (size, coating), for 22 the mutagenic activity as varying severity was found. These few numbers of positive results show that the degree of the mutagenic effect of nanomaterials may depend on the conditions of the experiment as well as coating composition. So, the diversity of nanomaterials and the sharp change in their properties even with a slight shift in the particle size parameters leads to the necessity to study the mutagenic activity of each nanomaterial separately. We conclude that there is the necessity to elaborate special international documents with the reglament of the investigation of nanomaterials’ mutagenic properties in the Ames test using the range of concentrations, with the full set of indicator strains and the description of the exact dimensions and properties of the studied particles." @default.
- W3003297751 created "2020-02-07" @default.
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- W3003297751 date "2019-11-15" @default.
- W3003297751 modified "2023-10-01" @default.
- W3003297751 title "MUTAGENIC ACTIVITY OF NANOMATERIALS IN THE AMES TEST. LITERATURE REVIEW" @default.
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- W3003297751 doi "https://doi.org/10.18821/0016-9900-2019-98-11-1309-1320" @default.
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