FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003301494> ?p ?o ?g. }

• W3003301494 endingPage "1570" @default.
• W3003301494 startingPage "1562" @default.
• W3003301494 abstract "Abstract In this study, we generated a tkl1 deletion mutant in the Toxoplasma gondii type 1 RH (RHΔtkl1) strain and tested the protective efficacies of vaccination using RHΔtkl1 tachyzoites against acute, chronic, and congenital T. gondii infections in Kunming mice. Mice vaccinated with RHΔtkl1 mounted a strong humoral and cellular response as shown by elevated levels of anti–T. gondii–specific IgG, IL-2, IL-12, IFN-γ, and IL-10. All RHΔtkl1-vaccinated mice survived a lethal challenge with 1 × 103 tachyzoites of type 1 RH or ToxoDB#9 (PYS or TgC7) strain as well as 100 cysts or oocysts of Prugniuad strain. All mock-vaccinated plus infected mice have died. Vaccination also protected against cyst- or oocyst-caused chronic infection, reduced vertical transmission caused by oocysts, increased litter size, and maintained body weight of pups born to dams challenged with 10 oocysts on day 5 of gestation. In contrast, all mock-vaccinated plus oocysts-infected dams had aborted, and no fetus has survived. Vaccinated dams remained healthy postinfection, and their brain cyst burden was significantly reduced compared with mock-vaccinated dams infected with oocysts. In vivo depletion of CD4+ T cells, CD8+ T cells, and B cells revealed that CD8+ T cells are involved in the protection of mice against T. gondii infection. Additionally, adoptive transfer of CD8+ T cells from RHΔtkl1-vaccinated mice significantly enhanced the survival of naive mice infected with the pathogenic strain. Together, these data reaffirm the importance of CD8+ T cell responses in future vaccine design for toxoplasmosis and present T. gondii tkl1 gene as a promising vaccine candidate." @default.
• W3003301494 created "2020-02-07" @default.
• W3003301494 creator A5001246506 @default.
• W3003301494 creator A5002669392 @default.
• W3003301494 creator A5019326487 @default.
• W3003301494 creator A5031689588 @default.
• W3003301494 creator A5056915722 @default.
• W3003301494 creator A5061396145 @default.
• W3003301494 creator A5063264774 @default.
• W3003301494 creator A5087659604 @default.
• W3003301494 date "2020-03-15" @default.
• W3003301494 modified "2023-10-18" @default.
• W3003301494 title "<i>Toxoplasma gondii tkl1</i> Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice" @default.
• W3003301494 cites W1817671189 @default.
• W3003301494 cites W1867290607 @default.
• W3003301494 cites W1893249709 @default.
• W3003301494 cites W1947939079 @default.
• W3003301494 cites W1973835409 @default.
• W3003301494 cites W1992653134 @default.
• W3003301494 cites W1995866519 @default.
• W3003301494 cites W1998047654 @default.
• W3003301494 cites W2011418155 @default.
• W3003301494 cites W2038982445 @default.
• W3003301494 cites W2051236462 @default.
• W3003301494 cites W2060667154 @default.
• W3003301494 cites W2080105845 @default.
• W3003301494 cites W2118412418 @default.
• W3003301494 cites W2125205431 @default.
• W3003301494 cites W2132709753 @default.
• W3003301494 cites W2143229107 @default.
• W3003301494 cites W2146771667 @default.
• W3003301494 cites W2153032016 @default.
• W3003301494 cites W2165394762 @default.
• W3003301494 cites W216692503 @default.
• W3003301494 cites W2168387989 @default.
• W3003301494 cites W2177365876 @default.
• W3003301494 cites W2392391520 @default.
• W3003301494 cites W2532117090 @default.
• W3003301494 cites W2584923474 @default.
• W3003301494 cites W2619378031 @default.
• W3003301494 cites W2725797872 @default.
• W3003301494 cites W2790611808 @default.
• W3003301494 cites W2798141849 @default.
• W3003301494 cites W2809949198 @default.
• W3003301494 cites W2889776706 @default.
• W3003301494 cites W2895304117 @default.
• W3003301494 cites W2900744091 @default.
• W3003301494 cites W2905856997 @default.
• W3003301494 cites W2912655637 @default.
• W3003301494 cites W2979424267 @default.
• W3003301494 cites W2979749284 @default.
• W3003301494 cites W4313347710 @default.
• W3003301494 doi "https://doi.org/10.4049/jimmunol.1900410" @default.
• W3003301494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31996457" @default.
• W3003301494 hasPublicationYear "2020" @default.
• W3003301494 type Work @default.
• W3003301494 sameAs 3003301494 @default.
• W3003301494 citedByCount "15" @default.
• W3003301494 countsByYear W30033014942020 @default.
• W3003301494 countsByYear W30033014942021 @default.
• W3003301494 countsByYear W30033014942022 @default.
• W3003301494 countsByYear W30033014942023 @default.
• W3003301494 crossrefType "journal-article" @default.
• W3003301494 hasAuthorship W3003301494A5001246506 @default.
• W3003301494 hasAuthorship W3003301494A5002669392 @default.
• W3003301494 hasAuthorship W3003301494A5019326487 @default.
• W3003301494 hasAuthorship W3003301494A5031689588 @default.
• W3003301494 hasAuthorship W3003301494A5056915722 @default.
• W3003301494 hasAuthorship W3003301494A5061396145 @default.
• W3003301494 hasAuthorship W3003301494A5063264774 @default.
• W3003301494 hasAuthorship W3003301494A5087659604 @default.
• W3003301494 hasBestOaLocation W30033014941 @default.
• W3003301494 hasConcept C104317684 @default.
• W3003301494 hasConcept C159047783 @default.
• W3003301494 hasConcept C159654299 @default.
• W3003301494 hasConcept C167672396 @default.
• W3003301494 hasConcept C203014093 @default.
• W3003301494 hasConcept C22070199 @default.
• W3003301494 hasConcept C2776090121 @default.
• W3003301494 hasConcept C2778062946 @default.
• W3003301494 hasConcept C2778128430 @default.
• W3003301494 hasConcept C54602769 @default.
• W3003301494 hasConcept C55493867 @default.
• W3003301494 hasConcept C60987743 @default.
• W3003301494 hasConcept C86803240 @default.
• W3003301494 hasConcept C8891405 @default.
• W3003301494 hasConcept C90375314 @default.
• W3003301494 hasConceptScore W3003301494C104317684 @default.
• W3003301494 hasConceptScore W3003301494C159047783 @default.
• W3003301494 hasConceptScore W3003301494C159654299 @default.
• W3003301494 hasConceptScore W3003301494C167672396 @default.
• W3003301494 hasConceptScore W3003301494C203014093 @default.
• W3003301494 hasConceptScore W3003301494C22070199 @default.
• W3003301494 hasConceptScore W3003301494C2776090121 @default.
• W3003301494 hasConceptScore W3003301494C2778062946 @default.
• W3003301494 hasConceptScore W3003301494C2778128430 @default.
• W3003301494 hasConceptScore W3003301494C54602769 @default.
• W3003301494 hasConceptScore W3003301494C55493867 @default.

• next