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- W3003303911 abstract "Abstract Brain glucose hypometabolism has been singled out as an important contributor and possibly main trigger to Alzheimer’s disease (AD). Intracerebroventricular injections of streptozotocin (icv-STZ) cause brain glucose hypometabolism without systemic diabetes. Here, a first-time longitudinal study of brain glucose metabolism, functional connectivity and white matter microstructure was performed in icv-STZ rats using PET and MRI. Histological markers of pathology were tested at an advanced stage of disease. STZ rats exhibited altered functional connectivity and intra-axonal damage and demyelination in brain regions typical of AD, in a temporal pattern of acute injury, transient recovery/compensation and chronic degeneration. In the context of sustained glucose hypometabolism, these nonmonotonic trends – also reported in behavioral studies of this animal model as well as in human AD – suggest a compensatory mechanism, possibly recruiting ketone bodies, that allows a partial and temporary repair of brain structure and function. The early acute phase could thus become a valuable therapeutic window to strengthen the recovery phase and prevent or delay chronic degeneration, to be considered both in preclinical and clinical studies of AD. In conclusion, this work reveals the consequences of brain insulin resistance on structure and function, highlights signature nonmonotonic trajectories in their evolution and proposes potent MRI-derived biomarkers translatable to human AD and diabetic populations." @default.
- W3003303911 created "2020-02-07" @default.
- W3003303911 creator A5000137061 @default.
- W3003303911 creator A5010098260 @default.
- W3003303911 creator A5011059352 @default.
- W3003303911 creator A5029409294 @default.
- W3003303911 creator A5056629861 @default.
- W3003303911 creator A5079906423 @default.
- W3003303911 creator A5083295201 @default.
- W3003303911 date "2020-01-31" @default.
- W3003303911 modified "2023-09-23" @default.
- W3003303911 title "Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer’s disease" @default.
- W3003303911 cites W1144597879 @default.
- W3003303911 cites W1486416255 @default.
- W3003303911 cites W1546369396 @default.
- W3003303911 cites W1600463053 @default.
- W3003303911 cites W1760829075 @default.
- W3003303911 cites W1802455527 @default.
- W3003303911 cites W1812507791 @default.
- W3003303911 cites W1836749191 @default.
- W3003303911 cites W1906792472 @default.
- W3003303911 cites W1968531410 @default.
- W3003303911 cites W1970928383 @default.
- W3003303911 cites W1976714975 @default.
- W3003303911 cites W1980190852 @default.
- W3003303911 cites W1981000616 @default.
- W3003303911 cites W1989119697 @default.
- W3003303911 cites W1992218510 @default.
- W3003303911 cites W1993571512 @default.
- W3003303911 cites W1997417397 @default.
- W3003303911 cites W2005299560 @default.
- W3003303911 cites W2006096283 @default.
- W3003303911 cites W2008245886 @default.
- W3003303911 cites W2008301592 @default.
- W3003303911 cites W2017159332 @default.
- W3003303911 cites W2033809837 @default.
- W3003303911 cites W2035873080 @default.
- W3003303911 cites W2041119928 @default.
- W3003303911 cites W2042422091 @default.
- W3003303911 cites W2052530454 @default.
- W3003303911 cites W2052644075 @default.
- W3003303911 cites W2059159698 @default.
- W3003303911 cites W2060482739 @default.
- W3003303911 cites W2061053265 @default.
- W3003303911 cites W2064091891 @default.
- W3003303911 cites W2071263424 @default.
- W3003303911 cites W2074611211 @default.
- W3003303911 cites W2078630811 @default.
- W3003303911 cites W2083234722 @default.
- W3003303911 cites W2093707752 @default.
- W3003303911 cites W2106775021 @default.
- W3003303911 cites W2108875608 @default.
- W3003303911 cites W2113872068 @default.
- W3003303911 cites W2116823839 @default.
- W3003303911 cites W2117621792 @default.
- W3003303911 cites W2121605483 @default.
- W3003303911 cites W2127309075 @default.
- W3003303911 cites W2129497119 @default.
- W3003303911 cites W2130418945 @default.
- W3003303911 cites W2135148756 @default.
- W3003303911 cites W2136145485 @default.
- W3003303911 cites W2142018683 @default.
- W3003303911 cites W2145331523 @default.
- W3003303911 cites W2148325823 @default.
- W3003303911 cites W2151716122 @default.
- W3003303911 cites W2153413087 @default.
- W3003303911 cites W2164047138 @default.
- W3003303911 cites W2167356488 @default.
- W3003303911 cites W2170765166 @default.
- W3003303911 cites W2177835590 @default.
- W3003303911 cites W2217108923 @default.
- W3003303911 cites W2269202100 @default.
- W3003303911 cites W2274873430 @default.
- W3003303911 cites W2343609596 @default.
- W3003303911 cites W2508982726 @default.
- W3003303911 cites W2516824864 @default.
- W3003303911 cites W2526035417 @default.
- W3003303911 cites W2567460568 @default.
- W3003303911 cites W2755595323 @default.
- W3003303911 cites W2765164306 @default.
- W3003303911 cites W2765221929 @default.
- W3003303911 cites W2768271247 @default.
- W3003303911 cites W2790798430 @default.
- W3003303911 cites W2791891181 @default.
- W3003303911 cites W2792405104 @default.
- W3003303911 cites W2793474747 @default.
- W3003303911 cites W2798885694 @default.
- W3003303911 cites W2802493769 @default.
- W3003303911 cites W2811122574 @default.
- W3003303911 cites W2883910861 @default.
- W3003303911 cites W2887206520 @default.
- W3003303911 cites W2898075767 @default.
- W3003303911 cites W2913334837 @default.
- W3003303911 cites W2923160173 @default.
- W3003303911 cites W2942087400 @default.
- W3003303911 cites W2947962850 @default.
- W3003303911 cites W2952477531 @default.
- W3003303911 cites W2962681100 @default.
- W3003303911 cites W2963028315 @default.
- W3003303911 cites W2963156163 @default.