Matches in SemOpenAlex for { <https://semopenalex.org/work/W3003307384> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3003307384 abstract "Abstract We evaluated the protective effect and toxicity of extracts from Mylabris phalerata Pallas by measuring the activated partial thromboplastin time, prothrombin time, venous thrombosis and acute toxicity in rats. Results showed the petroleum ether and water fractions of M. phalerata inhibited thrombosis but hardly prolonged the activated partial thromboplastin time and prothrombin time in rats. The trichloromethane fraction had obvious toxicity with an LD 50 of 0.2 g/kg in vivo , and contained many cantharidin analogs (CAs) by ultra‐performance liquid chromatography–quadrupole ion trap–tandem mass spectrometry (UPLC–QTRAP–MS/MS). CAs are the major potential bioactivity constituent in M. phalerata . An effective and reliable UPLC–QTRAP–MS/MS method was successfully developed to separate and identify CAs. The fragmentation patterns of five purified compounds were applied to elucidate the structure of their analogs. Thirty‐four CAs were characterized or tentatively identified, eight of which are proposed to be novel compounds ( 13 – 17 , 20 , 21 , 23 ), and their fragmentation patterns were investigated for the first time. Most importantly, a rapid and reliable UPLC–MS method was developed to identify the CAs of M. phalerata . This method has contributed to the discovery of most of these unknown analogs or their metabolites in M. phalerata effectively and quickly, and does not rely on limited chemical structural diversity libraries." @default.
- W3003307384 created "2020-02-07" @default.
- W3003307384 creator A5001254518 @default.
- W3003307384 creator A5038985889 @default.
- W3003307384 creator A5050402519 @default.
- W3003307384 creator A5058096961 @default.
- W3003307384 creator A5061158380 @default.
- W3003307384 creator A5074722268 @default.
- W3003307384 date "2020-04-03" @default.
- W3003307384 modified "2023-09-27" @default.
- W3003307384 title "Rapid profiling of cantharidin analogs in <i>Mylabris phalerata</i> Pallas by ultra‐performance liquid chromatography–quadrupole time‐of‐flight–tandem mass spectrometry" @default.
- W3003307384 cites W1972261424 @default.
- W3003307384 cites W1995022664 @default.
- W3003307384 cites W2024028023 @default.
- W3003307384 cites W2026316381 @default.
- W3003307384 cites W2106674838 @default.
- W3003307384 cites W2121221467 @default.
- W3003307384 cites W2245223179 @default.
- W3003307384 cites W2333884926 @default.
- W3003307384 cites W2478097000 @default.
- W3003307384 cites W2750498584 @default.
- W3003307384 cites W2804039955 @default.
- W3003307384 cites W4229694566 @default.
- W3003307384 doi "https://doi.org/10.1002/bmc.4801" @default.
- W3003307384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31999361" @default.
- W3003307384 hasPublicationYear "2020" @default.
- W3003307384 type Work @default.
- W3003307384 sameAs 3003307384 @default.
- W3003307384 citedByCount "4" @default.
- W3003307384 countsByYear W30033073842021 @default.
- W3003307384 countsByYear W30033073842023 @default.
- W3003307384 crossrefType "journal-article" @default.
- W3003307384 hasAuthorship W3003307384A5001254518 @default.
- W3003307384 hasAuthorship W3003307384A5038985889 @default.
- W3003307384 hasAuthorship W3003307384A5050402519 @default.
- W3003307384 hasAuthorship W3003307384A5058096961 @default.
- W3003307384 hasAuthorship W3003307384A5061158380 @default.
- W3003307384 hasAuthorship W3003307384A5074722268 @default.
- W3003307384 hasConcept C111919701 @default.
- W3003307384 hasConcept C118552586 @default.
- W3003307384 hasConcept C15744967 @default.
- W3003307384 hasConcept C162356407 @default.
- W3003307384 hasConcept C178790620 @default.
- W3003307384 hasConcept C179998833 @default.
- W3003307384 hasConcept C185592680 @default.
- W3003307384 hasConcept C191015642 @default.
- W3003307384 hasConcept C2778261982 @default.
- W3003307384 hasConcept C2778382381 @default.
- W3003307384 hasConcept C2780906345 @default.
- W3003307384 hasConcept C31827203 @default.
- W3003307384 hasConcept C41008148 @default.
- W3003307384 hasConcept C43617362 @default.
- W3003307384 hasConceptScore W3003307384C111919701 @default.
- W3003307384 hasConceptScore W3003307384C118552586 @default.
- W3003307384 hasConceptScore W3003307384C15744967 @default.
- W3003307384 hasConceptScore W3003307384C162356407 @default.
- W3003307384 hasConceptScore W3003307384C178790620 @default.
- W3003307384 hasConceptScore W3003307384C179998833 @default.
- W3003307384 hasConceptScore W3003307384C185592680 @default.
- W3003307384 hasConceptScore W3003307384C191015642 @default.
- W3003307384 hasConceptScore W3003307384C2778261982 @default.
- W3003307384 hasConceptScore W3003307384C2778382381 @default.
- W3003307384 hasConceptScore W3003307384C2780906345 @default.
- W3003307384 hasConceptScore W3003307384C31827203 @default.
- W3003307384 hasConceptScore W3003307384C41008148 @default.
- W3003307384 hasConceptScore W3003307384C43617362 @default.
- W3003307384 hasIssue "6" @default.
- W3003307384 hasLocation W30033073841 @default.
- W3003307384 hasOpenAccess W3003307384 @default.
- W3003307384 hasPrimaryLocation W30033073841 @default.
- W3003307384 hasRelatedWork W2015020400 @default.
- W3003307384 hasRelatedWork W2029727067 @default.
- W3003307384 hasRelatedWork W2033909045 @default.
- W3003307384 hasRelatedWork W2035971591 @default.
- W3003307384 hasRelatedWork W2045541026 @default.
- W3003307384 hasRelatedWork W2048027784 @default.
- W3003307384 hasRelatedWork W2059628166 @default.
- W3003307384 hasRelatedWork W2087497629 @default.
- W3003307384 hasRelatedWork W2107172911 @default.
- W3003307384 hasRelatedWork W50107102 @default.
- W3003307384 hasVolume "34" @default.
- W3003307384 isParatext "false" @default.
- W3003307384 isRetracted "false" @default.
- W3003307384 magId "3003307384" @default.
- W3003307384 workType "article" @default.